Search Results - "Orienti, Isabella"

Fenretinide in Cancer and Neurological Disease: A Two-Face Janus Molecule by Potenza, Rosa Luisa, Lodeserto, Pietro, Orienti, Isabella

“…Recently, several chemotherapeutic drugs have been repositioned in neurological diseases, based on common biological backgrounds and the inverse comorbidity…”
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Pulmonary Delivery of Fenretinide: A Possible Adjuvant Treatment In COVID-19 by Orienti, Isabella, Gentilomi, Giovanna Angela, Farruggia, Giovanna

“…At present, there is no vaccine or effective standard treatment for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection (or coronavirus…”
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Nano-fenretinide demonstrates remarkable activity in acute promyeloid leukemia cells by Farruggia, Giovanna, Anconelli, Lorenzo, Galassi, Lucrezia, Voltattorni, Manuela, Rossi, Martina, Lodeserto, Pietro, Blasi, Paolo, Orienti, Isabella

“…Acute promyelocytic leukemia (APL) is characterized by rearrangements of the retinoic acid receptor, RARα, which makes all-trans  retinoic acid (ATRA) highly…”
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Nanospermidine in Combination with Nanofenretinide Induces Cell Death in Neuroblastoma Cell Lines by Lodeserto, Pietro, Rossi, Martina, Blasi, Paolo, Farruggia, Giovanna, Orienti, Isabella

“…A new strategy to cause cell death in tumors might be the increase of intracellular polyamines at concentrations above their physiological values to trigger…”
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A nanoencapsulated oral formulation of fenretinide promotes local and metastatic breast cancer dormancy in HER2/neu transgenic mice by De Angelis, Maria Laura, Francescangeli, Federica, Aricò, Eleonora, Verachi, Paola, Zucchetti, Massimo, Matteo, Cristina, Petricci, Elena, Pilozzi, Emanuela, Orienti, Isabella, Boe, Alessandra, Eramo, Adriana, Rossi, Rachele, Corati, Tiberio, Macchia, Daniele, Pacca, Anna Maria, Zeuner, Ann, Baiocchi, Marta

“…Abstract Background Prevention and treatment of metastatic breast cancer (BC) is an unmet clinical need. The retinoic acid derivative fenretinide (FeR) was…”
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Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering by Orienti, Isabella, Salvatore, Viviana, Teti, Gabriella, Focaroli, Stefano, Falconi, Mirella

“…Articular cartilage is a highly organized tissue with complex biomechanical properties. However, injuries to the cartilage usually lead to numerous health…”
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Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine by Galassi, Lucrezia, Rossi, Martina, Lodeserto, Pietro, Lenzi, Monia, Borsetti, Francesca, Voltattorni, Manuela, Farruggia, Giovanna, Blasi, Paolo, Orienti, Isabella

“…Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes,…”
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A novel oral micellar fenretinide formulation with enhanced bioavailability and antitumour activity against multiple tumours from cancer stem cells by Orienti, Isabella, Salvati, Valentina, Sette, Giovanni, Zucchetti, Massimo, Bongiorno-Borbone, Lucilla, Peschiaroli, Angelo, Zolla, Lello, Francescangeli, Federica, Ferrari, Mariella, Matteo, Cristina, Bello, Ezia, Di Virgilio, Antonio, Falchi, Mario, De Angelis, Maria Laura, Baiocchi, Marta, Melino, Gerry, De Maria, Ruggero, Zeuner, Ann, Eramo, Adriana

“…An increasing number of anticancer agents has been proposed in recent years with the attempt to overcome treatment-resistant cancer cells and particularly…”
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Validated LC-MS/MS Assay for the Quantitative Determination of Fenretinide in Plasma and Tumor and Its Application in a Pharmacokinetic Study in Mice of a Novel Oral Nanoformulation of Fenretinide by Matteo, Cristina, Orienti, Isabella, Eramo, Adriana, Zeuner, Ann, Ferrari, Mariella, Passoni, Alice, Bagnati, Renzo, Ponzo, Marianna, Bello, Ezia, Zucchetti, Massimo, Frapolli, Roberta

“…We describe the development and validation of a HPLC-MS/MS method to assess the pharmacokinetics and tumor distribution of fenretinide, a synthetic retinoid…”
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Albumin nanocapsules containing fenretinide: pre-clinical evaluation of cytotoxic activity in experimental models of human non-small cell lung cancer by Pignatta, Sara, BSc, Orienti, Isabella, PhD, Falconi, Mirella, MD, PhD, Teti, Gabriella, PhD, Arienti, Chiara, BSc, Medri, Laura, BSc, Zanoni, Michele, BSc, Carloni, Silvia, BSc, Zoli, Wainer, BSc, Amadori, Dino, MD, Tesei, Anna, MBiochem, PhD

“…Abstract The present study deals with the preparation of albumin nanocapsules containing fenretinide and their evaluation in experimental models of human…”
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A Cationic Nanomicellar Complex of the Quaternary Amphiphilic Amine RC16+ with Fenretinide as a New Multitasking System for Antitumor Therapy by Orienti, Isabella, Cripe, Timothy P, Currier, Mark A, Cavallari, Cristina, Teti, Gabriella, Falconi, Mirella

“…This study investigated the antitumor effect of a new nanomicellar complex obtained by combining the antitumor agent fenretinide with a quaternary amphiphilic…”
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Sodium ascorbate induces apoptosis in neuroblastoma cell lines by interfering with iron uptake by Carosio, Roberta, Zuccari, Guendalina, Orienti, Isabella, Mangraviti, Salvatore, Montaldo, Paolo G

“…Neuroblastoma (NB) is an extra-cranial solid tumour of childhood. In spite of the good clinical response to first-line therapy, complete eradication of NB…”
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Novel micelles based on amphiphilic branched PEG as carriers for fenretinide by Orienti, Isabella, PhD, Zuccari, Guendalina, PhD, Falconi, Mirella, MD, PhD, Teti, Gabriella, PhD, Illingworth, Nicola A., PhD, Veal, Gareth J., PhD

“…Abstract This study reports on the preparation and evaluation of amphiphilic macromolecules based on branched polyethylene glycol covalently linked with alkyl…”
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In vitro and In vivo Antitumor Activity of the Novel Derivatized Polyvinyl Alcohol-Based Polymer P10(4) by RAFFAGHELLO, Lizzie, ZUCCARI, Guendalina, CAROSIO, Roberta, ORIENTI, Isabella, MONTALDO, Paolo G

“…Purpose: The major limitation to successful chemotherapy of neuroblastoma is the toxicity of traditional antitumor drugs. Hence, less toxic and more effective…”
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Fenretinide Beneficial Effects on Amyotrophic Lateral Sclerosis-associated SOD1G93A Mutant Protein Toxicity: In Vitro and In Vivo Evidences by Orienti, Isabella, Armida, Monica, Dobrowolny, Gabriella, Pepponi, Rita, Sollazzini, Gabriella, Pezzola, Antonella, Casola, Irene, Musarò, Antonio, Popoli, Patrizia, Potenza, Rosa Luisa

“…•Fenretinide (N-(4-hydroxyphenyl)retinamide) prevents the toxicity of mutant SOD1 (mSOD1) in NSC-34 motoneurons.•Fenretinide partially overcome the toxic…”
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A new bioavailable fenretinide formulation with antiproliferative, antimetabolic, and cytotoxic effects on solid tumors by Orienti, Isabella, Francescangeli, Federica, De Angelis, Maria Laura, Fecchi, Katia, Bongiorno-Borbone, Lucilla, Signore, Michele, Peschiaroli, Angelo, Boe, Alessandra, Bruselles, Alessandro, Costantino, Angelita, Eramo, Adriana, Salvati, Valentina, Sette, Giovanni, Contavalli, Paola, Zolla, Lello, Oki, Toshihiko, Kitamura, Toshio, Spada, Massimo, Giuliani, Alessandro, Baiocchi, Marta, La Torre, Filippo, Melino, Gerry, Tartaglia, Marco, De Maria, Ruggero, Zeuner, Ann

“…Fenretinide is a synthetic retinoid characterized by anticancer activity in preclinical models and favorable toxicological profile, but also by a low…”
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Antiproliferative and Morphological Effects of Fenretinide Lipid Nanosystems in Colon Adenocarcinoma Cells by Anconelli, Lorenzo, Farioli, Francesca, Lodeserto, Pietro, Andreadi, Aikaterini, Borsetti, Francesca, Voltattorni, Manuela, Galassi, Lucrezia, Rossi, Martina, Farruggia, Giovanna, Blasi, Paolo, Orienti, Isabella

“…Objective: Colon adenocarcinoma is characterized by the downregulation of the retinoic acid receptor, making natural retinoids such as all-trans retinoic acid,…”
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RARE-08. POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS IDENTIFIED THROUGH HIGH THROUGHPUT DRUG SCREENING by Upton, Dannielle, Valvi, Santosh, Liu, Jie, Yeung, Nicole, George, Sandra, Ung, Caitlin, Khan, Aaminah, Franshaw, Laura, Ehteda, Anahid, Shen, Han, Orienti, Isabella, Farruggia, Giovanna, Reynolds, Patrick, Tsoli, Maria, Ziegler, David

“…Abstract Diffuse Intrinsic Pontine Gliomas (DIPGs) are the most devastating of all brain tumors. There are no effective treatments, hence almost all children…”
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Anti-tumor activity of fenretinide complexed with human serum albumin in lung cancer xenograft mouse model by Durante, Sandra, Orienti, Isabella, Teti, Gabriella, Salvatore, Viviana, Focaroli, Stefano, Tesei, Anna, Pignatta, Sara, Falconi, Mirella

“…Sufficient knowledge regarding cellular and molecular basis of lung cancer progression and metastasis would help in the development of novel and effective…”
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DIPG-07. HIGH THROUGHPUT DRUG SCREENING IDENTIFIES POTENTIAL NEW THERAPIES FOR DIFFUSE INTRINSIC PONTINE GLIOMAS (DIPGs) by Upton, Dannielle, Valvi, Santosh, Liu, Jie, Yeung, Nicole, George, Sandra, Ung, Caitlin, Khan, Aaminah, Franshaw, Laura, Ehteda, Anahid, Shen, Han, Orienti, Isabella, Farruggia, Giovanna, Nath, Christa, Reynolds, Patrick, Tsoli, Maria, Ziegler, David

“…Abstract DIPGs are the most devastating of all brain tumors. There are no effective treatments, hence almost all children will die of their tumor within 12…”
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