Search Results - "Orie, Nelson N."

Studies on vascular response to full superantigens and superantigen derived peptides: Possible production of novel superantigen variants with less vasodilation effect for tolerable cancer immunotherapy by Bashraheel, Sara S., AlQahtani, Alanod D., Rashidi, Fatma B., Al-Sulaiti, Haya, Domling, Alexander, Orie, Nelson N., Goda, Sayed K.

“…[Display omitted] •The superantigens, SEA and SPEA caused dose-dependent relation of the ovine skeletal muscle (SKM).•The functional regions of SPEA that are…”
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Untargeted Metabolomics Identifies a Novel Panel of Markers for Autologous Blood Transfusion by Al-Nesf, Amna, Mohamed-Ali, Nada, Acquaah, Vanessa, Al-Jaber, Maneera, Al-Nesf, Maryam, Yassin, Mohamed A, Orie, Nelson N, Voss, Sven Christian, Georgakopoulos, Costas, Bhatt, Rikesh, Beotra, Alka, Mohamed-Ali, Vidya, Al-Maadheed, Mohammed

“…Untargeted metabolomics was used to analyze serum and urine samples for biomarkers of autologous blood transfusion (ABT). Red blood cell concentrates from…”
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Downregulation of CYP17A1 By 20-hydroxyecdysone: Plasma Progesterone and Its Vasodilatory Properties by Aljaber, Maneera Y, Orie, Nelson N, Raees, Asmaa, Kraiem, Suhail, Al-Jaber, Mashael, Samsam, Waseem, Hamza, Mostafa M, Abraham, David, Kneteman, Norman M, Beotra, Alka, Mohamed-Ali, Vidya, Almaadheed, Mohammed

“…AimTo investigate the effect of 20-hydroxyecdysone on steroidogenic pathway genes and plasma progesterone, and its potential impact on vascular functions…”
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20-hydroxyecdysone dilates muscle arterioles in a nitric oxide-dependent, estrogen ER-β receptor-independent manner by Orie, Nelson N, Raees, Asmaa, Aljaber, Maneera Y., Mohamed-Ali, Nada, Bensmail, Halima, Hamza, Mostafa M., Al-Ansari, Nasser, Beotra, Alka, Mohamed-Ali, Vidya, Almaadheed, Mohammed

“…•20-hydroxyecdysone dilates muscle arterioles in a nitric oxide-dependent manner.•NOS3 mRNA and proteins are upregulated by the compound in human endothelial…”
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Chronic reduction of store operated Ca2+ entry is viable therapeutically but is associated with cardiovascular complications by Yu, Fang, Courjaret, Raphael, Elmi, Asha, Adap, Ethel Alcantara, Orie, Nelson N., Zghyer, Fawzi, Hubrack, Satanay, Hayat, Sajad, Asaad, Nidal, Worgall, Stefan, Suthanthiran, Manikkam, Ali, Vidya Mohamed, Machaca, Khaled

“…Loss of function mutations in store‐operated Ca2+ entry (SOCE) are associated with severe paediatric disorders in humans, including combined immunodeficiency,…”
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Chronic reduction of store operated Ca 2+ entry is viable therapeutically but is associated with cardiovascular complications by Yu, Fang, Courjaret, Raphael, Elmi, Asha, Adap, Ethel Alcantara, Orie, Nelson N, Zghyer, Fawzi, Hubrack, Satanay, Hayat, Sajad, Asaad, Nidal, Worgall, Stefan, Suthanthiran, Manikkam, Ali, Vidya Mohamed, Machaca, Khaled

“…Loss of function mutations in store-operated Ca entry (SOCE) are associated with severe paediatric disorders in humans, including combined immunodeficiency,…”
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Oxidant-induced disruption of vascular K+ channel function: Implications for diabetic vasculopathy by Nwokocha, Chukwuemeka, Palacios, Javier, Ojukwu, Victoria E., Nna, Victor Udo, Owu, Daniel Udofia, Nwokocha, Magdalene, McGrowder, Donovan, Orie, Nelson N.

“…Diabetes in humans a chronic metabolic disorder characterised by hyperglycaemia, it is associated with an increased risk of cardiovascular disease, disruptions…”
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Depot- and diabetes-specific differences in norepinephrine-mediated adipose tissue angiogenesis, vascular tone, collagen deposition and morphology in obesity by Shen, Lei, Dashwood, Michael R., Casale, Carlo, Orie, Nelson N., Evans, Ian M., Sufi, Pratik, Gray, Rosaire, Mohamed-Ali, Vidya

“…AIMSNorepinephrine (NE) is a known regulator of adipose tissue (AT) metabolism, angiogenesis, vasoconstriction and fibrosis. This may be through…”
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Altered cyclooxygenase-1 and enhanced thromboxane receptor activities underlie attenuated endothelial dilatory capacity of omental arteries in obesity by Raees, Asmaa, Bakhamis, Aysha, Mohamed-Ali, Vidya, Bashah, Moataz, Al-Jaber, Mashael, Abraham, David, Clapp, Lucie H., Orie, Nelson N.

“…Obesity is a risk factor for endothelial dysfunction, the severity of which is likely to vary depending on extent and impact of adiposity on the vasculature…”
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Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine by Mani, Ali R, Pannala, Ananth S, Orie, Nelson N, Ollosson, Richard, Harry, David, Rice-Evans, Catherine A, Moore, Kevin P

“…Reactive nitrogen species, such as peroxynitrite, can nitrate tyrosine in proteins to form nitrotyrosine. Nitrotyrosine is metabolized to…”
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Role of prostanoid IP and EP receptors in mediating vasorelaxant responses to PGI₂ analogues in rat tail artery: Evidence for Gᵢ/ₒ modulation via EP₃ receptors by Orie, Nelson N, Clapp, Lucie H

“…Prostanoid IP receptors coupled to Gs are thought to be the primary target for prostacyclin (PGI₂) analogues. However, these agents also activate prostanoid…”
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Horseradish‐peroxidase‐conjugated anti‐erythropoietin antibodies for direct recombinant human erythropoietin detection: Proof of concept by Voss, Sven C., Orie, Nelson N., El‐Saftawy, Wesal, Saghbazarian, Stephanie, Al‐Kaabi, Alanoud, Georgakopoulos, Costas, Athanasiadou, Ioanna, Mohamed‐Ali, Vidya, Al‐Maadheed, Mohammed

“…Antidoping testing for recombinant human erythropoietin (EPO) is routinely performed by gel electrophoresis followed by western blot analysis with primary and…”
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Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis by Barrett, Lucinda K, Orie, Nelson N, Taylor, Valerie, Stidwill, Raymond P, Clapp, Lucie H, Singer, Mervyn

“…OBJECTIVE:There is escalating interest in the therapeutic use of vasopressin in septic shock. However, little attention has focused on mechanisms underlying…”
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Evidence that inward rectifier K+ channels mediate relaxation by the PGI2 receptor agonist cicaprost via a cyclic AMP-independent mechanism by ORIE, Nelson N, FRY, Chris H, CLAPP, Lucie H

“…We investigated the role of the inward rectifier potassium (KIR) channel and the cyclic AMP-dependent pathway in mediating vasorelaxation induced by the…”
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Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis by Chan, Yi-Ling, Orie, Nelson N, Dyson, Alex, Taylor, Valerie, Stidwill, Raymond P, Clapp, Lucie H, Singer, Mervyn

“…OBJECTIVE:Excessive opening of the adenosine triphosphate-sensitive potassium channel in vascular smooth muscle is implicated in the vasodilation and vascular…”
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Stoking Up BKCa Channels in Hemorrhagic Shock: Which Channel Subunit Is Really Fueling the Fire? by Clapp, Lucie H, Orie, Nelson N

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Attenuated vascular responsiveness to K+ channel openers in diabetes mellitus: the differential role of reactive oxygen species by Owu, Daniel U, Orie, Nelson N, Nwokocha, Chukwuemeka R, Muzyamba, Morris, Clapp, Lucie H, Osim, Eme E

“…The current study examined the responsiveness of blood vessels from diabetic rats to K+ channel openers and explored whether ROS might be involved in any…”
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Increased intracellular reactive oxygen species in patients with end-stage renal failure: Effect of hemodialysis by Tepel, Martin, Echelmeyer, Martin, Orie, Nelson N., Zidek, Walter

“…Increased intracellular reactive oxygen species in patients with end-stage renal failure: Effect of hemodialysis. Reactive oxygen species (ROS) have been…”
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BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis by O'Brien, Alastair J, Terala, Deepti, Orie, Nelson N, Davies, Nathan A, Zolfaghari, Parjam, Singer, Mervyn, Clapp, Lucie H

“…Nitric oxide-mediated activation of large conductance calcium-activated potassium (BK) channels is considered an important underlying mechanism of…”
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S-nitroso-albumin carries a thiol-labile pool of nitric oxide, which causes venodilation in the rat by Orie, Nelson N, Vallance, Patrick, Jones, Dean P, Moore, Kevin P

“…It is now established that S-nitroso-albumin (SNO-albumin) circulates at low nanomolar concentrations under physiological conditions, but concentrations may…”
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