Search Results - "Oria, Reinaldo B"

Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome? by DeBoer, Mark D, Lima, Aldo AM, Oría, Reinaldo B, Scharf, Rebecca J, Moore, Sean R, Luna, Max A, Guerrant, Richard L

“…Hypotheses regarding the developmental origins of health and disease postulate that developing fetuses – and potentially young children – undergo adaptive…”
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Early Childhood Diarrhea Predicts Cognitive Delays in Later Childhood Independently of Malnutrition by Pinkerton, Relana, Oriá, Reinaldo B, Lima, Aldo A M, Rogawski, Elizabeth T, Oriá, Mônica O B, Patrick, Peter D, Moore, Sean R, Wiseman, Benjamin L, Niehaus, Mark D, Guerrant, Richard L

“…Understanding the complex relationship between early childhood infectious diseases, nutritional status, poverty, and cognitive development is significantly…”
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Malnutrition as an enteric infectious disease with long-term effects on child development by Guerrant, Richard L, Oria, Reinaldo B, Moore, Sean R, Oria, Monica O.B, Lima, Aldo A.M

“…Malnutrition is a major contributor to mortality and is increasingly recognized as a cause of potentially lifelong functional disability. Yet, a rate-limiting…”
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Early-life enteric infections: relation between chronic systemic inflammation and poor cognition in children by Oriá, Reinaldo B., Murray-Kolb, Laura E., Scharf, Rebecca J., Pendergast, Laura L., Lang, Dennis R., Kolling, Glynis L., Guerrant, Richard L.

“…The intestinal microbiota undergoes active remodeling in the first 6 to 18 months of life, during which time the characteristics of the adult microbiota are…”
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The Clinical Aspects of COVID and Alzheimer's Disease: A Round-Up of Where Things Stand and Are Headed by Tavares-Júnior, José Wagner Leonel, Ciurleo, Gabriella Cunha Vieira, Feitosa, Esther de Alencar Araripe Falcão, Oriá, Reinaldo B, Braga-Neto, Pedro

“… The link between long COVID-19 and brain/cognitive impairments is concerning and may foster a worrisome worldwide emergence of novel cases of…”
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Immunoinflammatory role of apolipoprotein E4 in malnutrition and enteric infections and the increased risk for chronic diseases under adverse environments by Freitas, Raul S, Roque, Cássia R, Matos, Gabriella A, Belayev, Ludmila, de Azevedo, Orleâncio G R, Alvarez-Leite, Jacqueline I, Guerrant, Richard L, Oriá, Reinaldo B

“…Abstract Apolipoprotein E plays a crucial role in cholesterol metabolism. The immunomodulatory functions of the human polymorphic APOE gene have gained…”
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Hair mercury is associated with dyslipidemia and cardiovascular risk: An anthropometric, biochemical and genetic cross-sectional study of Amazonian vulnerable populations by Lopes-Araújo, Amanda, Arrifano, Gabriela P., Macchi, Barbarella M., Augusto-Oliveira, Marcus, Santos-Sacramento, Letícia, Rodríguez Martín-Doimeadios, Rosa C., Jiménez-Moreno, María, Martins Filho, Arnaldo J., Alvarez-Leite, Jacqueline I., Oriá, Reinaldo B., do Nascimento, José Luiz M., Crespo-Lopez, Maria Elena

“…This cross-sectional study evaluated the association between human exposure to mercury and cardiovascular risk using lipid profile (including apolipoproteins)…”
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Chronic Methylmercury Intoxication Induces Systemic Inflammation, Behavioral, and Hippocampal Amino Acid Changes in C57BL6J Adult Mice by Nascimento, Tyciane S, Pinto, Daniel V, Dias, Ronaldo P, Raposo, Ramon S, Nunes, Paulo Iury G, Roque, Cássia R, Santos, Flávia A, Andrade, Geanne M, Viana, José Lucas, Fostier, Anne H, Sussulini, Alessandra, Alvarez-Leite, Jacqueline I, Fontes-Ribeiro, Carlos, Malva, João O, Oriá, Reinaldo B

“…Methylmercury (MeHg) is highly toxic to the human brain. Although much is known about MeHg neurotoxic effects, less is known about how chronic MeHg affects…”
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Prolonged Episodes of Acute Diarrhea Reduce Growth and Increase Risk of Persistent Diarrhea in Children by Moore, Sean R, Lima, Noélia L, Soares, Alberto M, Oriá, Reinaldo B, Pinkerton, Relana C, Barrett, Leah J, Guerrant, Richard L, Lima, Aldo A.M

“…Background & Aims Prolonged episodes of acute diarrhea (ProD; duration 7–13 days) or persistent diarrhea (PD; duration ≥14 days) are important causes of…”
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Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids by Moore, Sean R, Guedes, Marjorie M, Costa, Tie B, Vallance, Jefferson, Maier, Elizabeth A, Betz, Kristina J, Aihara, Eitaro, Mahe, Maxime M, Lima, Aldo A M, Oriá, Reinaldo B, Shroyer, Noah F

“…L-glutamine (Gln) is a key metabolic fuel for intestinal epithelial cell proliferation and survival and may be conditionally essential for gut homeostasis…”
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Methylmercury chronic exposure affects the expression of DNA single-strand break repair genes, induces oxidative stress, and chromosomal abnormalities in young dyslipidemic APOE knockout mice by Roque, Cássia R., Sampaio, Letícia R., Ito, Mayumi N., Pinto, Daniel V., Caminha, Juan S.R., Nunes, Paulo I.G., Raposo, Ramon S., Santos, Flávia A., Windmöller, Cláudia C., Crespo-Lopez, Maria Elena, Alvarez-Leite, Jacqueline I., Oriá, Reinaldo B., Pinheiro, Ronald F.

“…Mercury (Hg) is one of the most toxic environmental pollutants, especially when methylated, forming methylmercury (MeHg). MeHg affects DNA repair, increases…”
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Influence of angiotensin receptor and converting enzyme blockers therapy in the respiratory outcome of COVID-19 hospitalized patients by Lima, Felipe B, Muniz, Francisco Wilker Mustafa Gomes, Meneses, Gdayllon C, Bezerra, Karine C, Moreira, Carolyne N, Aguiar, André P, Nascimento, José Carlos R, Veras de S Freitas, Tainá, de Bruin, Pedro Felipe C, Pereira, Eanes Delgado B, Daher, Elizabeth de F, Oriá, Reinaldo B

“…COVID-19, caused by SARS-CoV-2, has spread around the world since 2019. In severe cases, COVID-19 can lead to hospitalization and death. Systemic arterial…”
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A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency by Q.S. Medeiros, Pedro Henrique, Ledwaba, Solanka E., Bolick, David T., Giallourou, Natasa, Yum, Lauren K., Costa, Deiziane V.S., Oriá, Reinaldo B., Barry, Eileen M., Swann, Jonathan R., Lima, Aldo Ângelo M., Agaisse, Hervé, Guerrant, Richard L.

“…Shigella is one of the major enteric pathogens worldwide. We present a murine model of S. flexneri infection and investigate the role of zinc deficiency (ZD)…”
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Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis by Nascimento, José Carlos Rodrigues, Pereira, Lianna C, Rêgo, Juliana Magalhães C, Dias, Ronaldo P, Silva, Paulo Goberlânio B, Sobrinho, Silvio Alencar C, Coelho, Gustavo R, Brasil, Ivelise Regina C, Oliveira-Filho, Edmilson F, Owen, James S, Toniutto, Pierluigi, Oriá, Reinaldo B

“…Hepatitis C virus (HCV) infection is responsible for a chronic liver inflammation, which may cause end-stage liver disease and hepatocellular carcinoma…”
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5-Fluorouracil disrupts ovarian preantral follicles in young C57BL6J mice by Almeida, Juliana Z., Lima, Laritza F., Vieira, Luís A., Maside, Carolina, Ferreira, Anna C. A., Araújo, Valdevane R., Duarte, Ana B. G., Raposo, Ramon S., Báo, Sônia N., Campello, Cláudio C., Oliveira, Luiz F. S., da Costa, Thayse P., Abreu, José Garcia, Figueiredo, José R., Oriá, Reinaldo B.

“…Purpose 5-Fluorouracil (5-FU), an anti-cancer drug, has been used for hepatoblastoma (HB) chemotherapy in children, who may have impaired  ovarian follicle…”
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Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice by Figueiredo, Ítalo Leite, DVM, PhD, Frota, Priscila B., MD, da Cunha, Davi G., MSc, da Silva Raposo, Ramon, DVM, PhD, Canuto, Kildere M., MSc, de Andrade, Geanne M., PhD, Sousa, Nuno, MD, PhD, Moore, Sean R., MD, PhD, Anstead, Gregory M., MD, Alvarez-Leite, Jacqueline I., MD, PhD, Guerrant, Richard L., MD, Oriá, Reinaldo B., DVM, PhD

“…Abstract Objective Prolonged maternal separation (PMS) in the first two weeks of life has been associated with poor growth with lasting effects in the brain…”
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Geography, Population, Demography, Socioeconomic, Anthropometry, and Environmental Status in the MAL-ED Cohort and Case-Control Study Sites in Fortaleza, Ceará, Brazil by Lima, Aldo A. M., Oriá, Reinaldo B., Soares, Alberto M., Filho, José Q., de Sousa, Francisco, Abreu, Cláudia B., Bindá, Alexandre, Lima, Ila, Quetz, Josiane, Moraes, Milena, Maciel, Bruna, Costa, Hilda, Leite, Álvaro M., Lima, Noélia L., Mota, Francisco S., Di Moura, Alessandra, Scharf, Rebecca, Barrett, Leah, Guerrant, Richard L.

“…The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort in the…”
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Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice by Azevedo, Orleâncio G R, Bolick, David T, Roche, James K, Pinkerton, Relana F, Lima, Aldo A M, Vitek, Michael P, Warren, Cirle A, Oriá, Reinaldo B, Guerrant, Richard L

“…Apolipoliprotein E (apoE), a critical targeting protein in lipid homeostasis, has been found to have immunoinflammatory effects on murine models of infection…”
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Apolipoprotein E4 and Alzheimer's disease causality under adverse environments and potential intervention by senolytic nutrients by Ciurleo, Gabriella C.V., de Azevedo, Orleâncio G.R., Carvalho, Camila G.M., Vitek, Michael P., Warren, Cirle A., Guerrant, Richard L., Oriá, Reinaldo B.

“…Apolipoprotein E (apoE) has a pivotal role in Alzheimer's Disease (AD) pathophysiology. APOE4 has been recognized as a risk factor for developing late-onset…”
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Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition by Bolick, David T, Chen, Tufeng, Alves, Luís Antonio O, Tong, Yixin, Wu, Di, Joyner, 2nd, Linwood T, Oriá, Reinaldo B, Guerrant, Richard L, Fu, Zheng

“…Nutritional deficiency and stress can severely impair intestinal architecture, integrity and host immune defense, leading to increased susceptibility to…”
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