Search Results - "Ori, Daisuke"

Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases by Okude, Haruna, Ori, Daisuke, Kawai, Taro

“…Recognition of pathogen-derived nucleic acids by pattern-recognition receptors (PRRs) is essential for eliciting antiviral immune responses by inducing the…”
Get full text

1′-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression by Sok, Sophia P M, Ori, Daisuke, Wada, Ayana, Okude, Haruna, Kawasaki, Takumi, Momota, Masatoshi, Nagoor, Noor Hasima, Kawai, Taro

“…Abstract The nucleotide-binding oligomerization domain-like receptor (NLR) family pyrin domain containing (NLRP) 3 inflammasome is a multiprotein complex that…”
Get full text

Inhibition of lipopolysaccharide‐induced inflammatory responses by 1′‐acetoxychavicol acetate by Ong, Guang Han, Ori, Daisuke, Kawasaki, Takumi, Kawai, Taro

“…Lipopolysaccharide on gram negative bacteria can be detected by Toll‐like receptor 4 (TLR4) to elicit a series of innate immune responses, leading to…”
Get full text

Hu Antigen R Regulates Antiviral Innate Immune Responses through the Stabilization of mRNA for Polo-like Kinase 2 by Sueyoshi, Takuya, Kawasaki, Takumi, Kitai, Yuichi, Ori, Daisuke, Akira, Shizuo, Kawai, Taro

“…Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs), RIG-I, and melanoma differentiation-associated gene 5 (MDA5) play a critical role in inducing…”
Get full text

The Ca2+-dependent pathway contributes to changes in the subcellular localization and extracellular release of interleukin-33 by Momota, Masatoshi, Nagayama, Mizuka, Okude, Haruna, Ishii, Ken J., Ori, Daisuke, Kawasaki, Takumi, Kawai, Taro

“…Interleukin-33 (IL-33) is a member of the IL-1 cytokine family and plays critical roles in facilitating type-2 immune responses. IL-33 is localized in the…”
Get full text

PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking by Dewi Pamungkas Putri, Dyaningtyas, Kawasaki, Takumi, Murase, Motoya, Sueyoshi, Takuya, Deguchi, Tomoya, Ori, Daisuke, Suetsugu, Shiro, Kawai, Taro

“…The innate immune system plays an essential role in initial recognition of pathogen infection by producing inflammatory cytokines and type I interferons. cGAS…”
Get full text

Essential Function for the Nuclear Protein Akirin2 in B Cell Activation and Humoral Immune Responses by Tartey, Sarang, Matsushita, Kazufumi, Imamura, Tomoko, Wakabayashi, Atsuko, Ori, Daisuke, Mino, Takashi, Takeuchi, Osamu

“…Akirin2, an evolutionarily conserved nuclear protein, is an important factor regulating inflammatory gene transcription in mammalian innate immune cells by…”
Get full text

Pathophysiological Role of Nucleic Acid-Sensing Pattern Recognition Receptors in Inflammatory Diseases by Kano, Norisuke, Ong, Guang Han, Ori, Daisuke, Kawai, Taro

“…Pattern recognition receptors (PRRs) play critical roles in recognizing pathogen-derived nucleic acids and inducing innate immune responses, such as…”
Get full text

Essential roles of K63-linked polyubiquitin-binding proteins TAB2 and TAB3 in B cell activation via MAPKs by Ori, Daisuke, Kato, Hiroki, Sanjo, Hideki, Tartey, Sarang, Mino, Takashi, Akira, Shizuo, Takeuchi, Osamu

“…Polyubiquitination of proteins plays a critical role in the activation of immune cells. K63-linked polyubiquitin-binding proteins TGF-β-activated kinase 1…”
Get full text

Regnase-1 Maintains Iron Homeostasis via the Degradation of Transferrin Receptor 1 and Prolyl-Hydroxylase-Domain-Containing Protein 3 mRNAs by Yoshinaga, Masanori, Nakatsuka, Yoshinari, Vandenbon, Alexis, Ori, Daisuke, Uehata, Takuya, Tsujimura, Tohru, Suzuki, Yutaka, Mino, Takashi, Takeuchi, Osamu

“…Iron metabolism is regulated by transcriptional and post-transcriptional mechanisms. The mRNA of the iron-controlling gene, transferrin receptor 1 (TfR1), has…”
Get full text

Negative Regulation of Melanoma Differentiation-associated Gene 5 (MDA5)-dependent Antiviral Innate Immune Responses by Arf-like Protein 5B by Kitai, Yuichi, Takeuchi, Osamu, Kawasaki, Takumi, Ori, Daisuke, Sueyoshi, Takuya, Murase, Motoya, Akira, Shizuo, Kawai, Taro

“…RIG-I-like receptors (RLRs), including retinoic acid-inducible gene-I (RIG-I) and MDA5, constitute a family of cytoplasmic RNA helicases that senses viral RNA…”
Get full text

Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site by Lian, Benedict Shi Xiang, Kawasaki, Takumi, Kano, Norisuke, Ori, Daisuke, Ikegawa, Moe, Isotani, Ayako, Kawai, Taro

“…The innate immune system is an immediate defense against infectious pathogens by the production of inflammatory cytokines and other mediators. Deficiencies of…”
Get full text

Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation by Fukasaka, Masahiro, Ori, Daisuke, Kawagoe, Tatsukata, Uematsu, Satoshi, Maruyama, Kenta, Okazaki, Toshihiko, Kozaki, Tatsuya, Imamura, Tomoko, Tartey, Sarang, Mino, Takashi, Satoh, Takashi, Akira, Shizuo, Takeuchi, Osamu

“…TNFR-associated factor family member-associated NF-κB activator (TANK)-binding kinase 1 (TBK1) is critical for the activation of IFN regulatory factor 3 and…”
Get full text

Pathophysiological functions of self-derived DNA by Ori, Daisuke, Kawai, Taro

“…Inflammation plays indispensable roles in building the immune responses such as acquired immunity against harmful pathogens. Furthermore, it is essential for…”
Get full text

Cytosolic nucleic acid sensors and innate immune regulation by Ori, Daisuke, Murase, Motoya, Kawai, Taro

“…During viral and bacterial infections, pathogen-derived cytosolic nucleic acids are recognized by the intracellular RNA sensors retinoic acid-inducible gene I…”
Get full text

Identification and characterization of putative enhancer regions that direct Il6 transcription in murine macrophages by Kano, Norisuke, Miki, Takeo, Uehara, Yurina, Ori, Daisuke, Kawai, Taro

“…Abstract Interleukin-6 (IL-6) plays a crucial role in various cellular functions, including innate and adaptive immune responses. Dysregulated expression of…”
Get full text

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms by Mino, Takashi, Murakawa, Yasuhiro, Fukao, Akira, Vandenbon, Alexis, Wessels, Hans-Hermann, Ori, Daisuke, Uehata, Takuya, Tartey, Sarang, Akira, Shizuo, Suzuki, Yutaka, Vinuesa, Carola G., Ohler, Uwe, Standley, Daron M., Landthaler, Markus, Fujiwara, Toshinobu, Takeuchi, Osamu

“…Regnase-1 and Roquin are RNA binding proteins essential for degradation of inflammation-related mRNAs and maintenance of immune homeostasis. However, their…”
Get full text

Identification of nucleoporin 93 (Nup93) that mediates antiviral innate immune responses by Monwan, Warunthorn, Kawasaki, Takumi, Hasan, Md Zobaer, Ori, Daisuke, Kawai, Taro

“…RIG-I-like receptors (RLRs) are cytoplasmic sensors for viral RNA that elicit antiviral innate immune responses. RLR signaling culminates in the activation of…”
Get full text

HuR by Fukuta, Mizuki, Hirano, Minato, Hewson, Roger, Yoshii, Kentaro, Kano, Norisuke, Kawai, Taro, Kawasaki, Takumi, Ori, Daisuke, Ikegawa, Moe

“…Crimean-Congo Hemorrhagic Fever virus (CCHFV) is a tick-borne pathogen that causes severe acute fever disease in humans and requires a biosafety level 4…”
Get full text

HuR (ELAVL1) regulates the CCHFV minigenome and HAZV replication by associating with viral genomic RNA by Ikegawa, Moe, Kano, Norisuke, Ori, Daisuke, Fukuta, Mizuki, Hirano, Minato, Hewson, Roger, Yoshii, Kentaro, Kawai, Taro, Kawasaki, Takumi

“…Crimean-Congo Hemorrhagic Fever virus (CCHFV) is a tick-borne pathogen that causes severe acute fever disease in humans and requires a biosafety level 4…”
Get full text