Search Results - "Orgel, Leslie E"

Prebiotic chemistry and the origin of the RNA world by Orgel, Leslie E

“…The demonstration that ribosomal peptide synthesis is a ribozyme-catalyzed reaction makes it almost certain that there was once an RNA World. The central…”
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The implausibility of metabolic cycles on the prebiotic Earth by Orgel, Leslie E

“…If complex cycles analogous to metabolic cycles could have operated on the primitive Earth, before the appearance of enzymes or other informational polymers,…”
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Self-Assembling Sequence-Adaptive Peptide Nucleic Acids by Ura, Yasuyuki, Beierle, John M, Leman, Luke J, Orgel, Leslie E, Ghadiri, M. Reza

“…Several classes of nucleic acid analogs have been reported, but no synthetic informational polymer has yet proven responsive to selection pressures under…”
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Self-Organizing Biochemical Cycles by Orgel, Leslie E.

“…I examine the plausibility of theories that postulate the development of complex chemical organization without requiring the replication of genetic polymers…”
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Synthesis of long prebiotic oligomers on mineral surfaces by Ferris, James P, Hill, Aubrey R, Liu, Rihe, Orgel, Leslie E

“…Most theories of the origin of biological organization assume that polymers with lengths in the range of 30-60 monomers are needed to make a genetic system…”
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Protein Disulfide Oxidoreductases and the Evolution of Thermophily: Was the Last Common Ancestor a Heat-Loving Microbe by Becerra, Arturo, Delaye, Luis, Lazcano, Antonio, Orgel, Leslie E

“…Protein disulfide oxidoreductases (PDOs) are redox enzymes that catalyze dithiol-disulfide exchange reactions. Their sequences and structure reveal the…”
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Template switching between PNA and RNA oligonucleotides by Bohler, C., Nielsen, P. E., Orgel, L. E., Miller, S. L.

“…The origin of the RNA world is not easily understood, as effective prebiotic syntheses of the components of RNA, the beta-ribofuranoside-5'-phosphates, are…”
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Remote Enantioselection Transmitted by an Achiral Peptide Nucleic Acid Backbone by Kozlov, Igor A., Orgel, Leslie E., Nielsen, Peter E.

“…short homochiral segment of DNA into a PNA helix could have guaranteed that the next short segment of DNA to be incorporated would have the same handedness as…”
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Nonenzymic template-directed synthesis on oligodeoxycytidylate sequences in hairpin oligonucleotides by Wu, Taifeng, Orgel, Leslie E

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The origin of life—a review of facts and speculations by Orgel, Leslie E.

“…Three popular hypotheses attempt to explain the origin of prebiotic molecules: synthesis in a reducing atmosphere, input in meteorites and synthesis on metal…”
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Nonenzymatic Synthesis of RNA and DNA Oligomers on Hexitol Nucleic Acid Templates:  The Importance of the A Structure by Kozlov, Igor A, Politis, Panagiotis K, Van Aerschot, Arthur, Busson, Roger, Herdewijn, Piet, Orgel, Leslie E

“…Hexitol nucleic acid (HNA) is an analogue of DNA containing the standard nucleoside bases, but with a phosphorylated 1,5-anhydrohexitol backbone. HNA oligomers…”
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A Highly Enantio-Selective Hexitol Nucleic Acid Template for Nonenzymatic Oligoguanylate Synthesis by Kozlov, Igor A, Politis, Panagiotis K, Pitsch, Stefan, Herdewijn, Piet, Orgel, Leslie E

“…The effect of L-guanosine 5'-phosphoro-2-methylimidazole (L-2-MeImpG) on the nonenzymatic oligomerization of the D-enantiomer (Figure 1a) on a poly(D-C)…”
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Amino Acid Dependent Formation of Phosphate Anhydrides in Water Mediated by Carbonyl Sulfide by Leman, Luke J, Orgel, Leslie E, Ghadiri, M. Reza

“…Carbonyl sulfide (COS), a component of volcanic gas emissions and interstellar gas clouds, is shown to be an efficient condensing agent in the context of…”
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Oligomerization of Activated D- and L-guanosine Mononucleotides on Templates Containing D- and L-deoxycytidylate Residues by Kozlov, Igor A., Pitsch, Stefan, Orgel, Leslie E.

“…The oligomerization of activated D- and L- and racemic guanosine-5′-phosphoro-2-methylimidazole on short templates containing D- and L-deoxycytidylate has been…”
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Nonenzymatic template-directed synthesis on hairpin oligonucleotides. 3. Incorporation of adenosine and uridine residues by Wu, Taifeng, Orgel, Leslie E

“…We have used [32P]-labeled hairpin oligonucleotides to study template-directed synthesis on templates containing one or more A or T residues within a run of C…”
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Enantiomeric Cross-Inhibition in the Synthesis of Oligonucleotides on a Nonchiral Template by Schmidt, Jürgen G, Nielsen, Peter E, Orgel, Leslie E

“…Prebiotic syntheses of chiral monomers always yield racemic mixtures. Living systems, however, utilize L-amino acids and D-nucleotides in their biopolymers…”
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Nucleic Acid Duplexes Incorporating a Dissociable Covalent Base Pair by Gao, Kui, Orgel, Leslie E.

“…We have used molecular modeling techniques to design a dissociable covalently bonded base pair that can replace a Watson-Crick base pair in a nucleic acid with…”
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Prebiotic adenine revisited: eutectics and photochemistry by Orgel, Leslie E

“…Recent studies support an earlier suggestion that, if adenine was formed prebiotically on the primitive earth, eutectic freezing of hydrogen cyanide solutions…”
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A Comparison of RNA with DNA in Template-Directed Synthesis by Zielinski, Magdalene, Kozlov, Igor A., Orgel, Leslie E.

“…Nonenzymatic template-directed copying of RNA sequences rich in cytidylic acid using nucleoside 5'-(2-methylimidazol-1-yl phosphates) as substrates is…”
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Molecular replication by Orgel, Leslie E.

“…Recent experiments demonstrating nonenzymatic replication in molecular systems are reviewed. The difficulties facing nonenzymatic replication are discussed…”
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