Search Results - "Orestes, Peihan"

Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain by Joksimovic, Sonja Lj, Joksimovic, Srdjan M., Manzella, Francesca M., Asnake, Betelehem, Orestes, Peihan, Raol, Yogendra H., Krishnan, Kathiresan, Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.

“…Background and Purpose Neuroactive steroid (3β,5β,17β)‐3‐hydroxyandrostane‐17‐carbonitrile (3β‐OH) is a novel hypnotic and voltage‐dependent blocker of T‐type…”
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Glycosylation of CaV3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes by Joksimovic, Sonja Lj, Evans, J. Grayson, McIntire, William E., Orestes, Peihan, Barrett, Paula Q., Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.

“…Our previous studies implicated glycosylation of the Ca V 3.2 isoform of T-type Ca 2+ channels (T-channels) in the development of Type 2 painful peripheral…”
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Mechanisms and functional significance of inhibition of neuronal T-type calcium channels by isoflurane by Orestes, Peihan, Bojadzic, Damir, Chow, Robert M, Todorovic, Slobodan M

“…Previous data have indicated that T-type calcium channels (low-voltage activated T-channels) are potently inhibited by volatile anesthetics. Although the…”
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Are neuronal voltage-gated calcium channels valid cellular targets for general anesthetics? by Orestes, Peihan, Todorovic, Slobodan M.

“…The effects of anesthetics and analgesics on ion channels have been the subject of intense research since recent reports of direct actions of anesthetic…”
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Mechanisms of inhibition of T-type calcium current in the reticular thalamic neurons by 1-octanol: implication of the protein kinase C pathway by Joksovic, Pavle M, Choe, Won Joo, Nelson, Michael T, Orestes, Peihan, Brimelow, Barbara C, Todorovic, Slobodan M

“…Recent studies indicate that T-type calcium channels (T-channels) in the thalamus are cellular targets for general anesthetics. Here, we recorded T-currents…”
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TRPV1-lineage neurons are required for thermal sensation by Mishra, Santosh K, Tisel, Sarah M, Orestes, Peihan, Bhangoo, Sonia K, Hoon, Mark A

“…The ion‐channel TRPV1 is believed to be a major sensor of noxious heat, but surprisingly animals lacking TRPV1 still display marked responses to elevated…”
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Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Cav3.2 T-Type Calcium Channels by ORESTES, Peihan, OSURU, Hari Prasad, POIRO, Nathan, DIGRUCCIO, Michael R, KRISHNAN, Katiresan, COVEY, Douglas F, LEE, Jung-Ha, BARRETT, Paula Q, JEVTOVIC-TODOROVIC, Vesna, TODOROVIC, Slobodan M, MCINTIRE, William E, JACUS, Megan O, SALAJEGHEH, Reza, JAGODIC, Miljen M, WONJOO CHOE, JEONGHAN LEE, LEE, Sang-Soo, ROSE, Kirstin E

“…It has been established that CaV3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of nociceptive…”
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Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels by Orestes, Peihan, Osuru, Hari Prasad, McIntire, William E, Jacus, Megan O, Salajegheh, Reza, Jagodic, Miljen M, Choe, Wonjoo, Lee, Jeonghan, Lee, Sang-Soo, Rose, Kirstin E, Poiro, Nathan, Digruccio, Michael R, Krishnan, Katiresan, Covey, Douglas F, Lee, Jung-Ha, Barrett, Paula Q, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…It has been established that Ca(V)3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of…”
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In vivo silencing of the CaV3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy by Messinger, Richard B., Naik, Ajit K., Jagodic, Miljen M., Nelson, Michael T., Lee, Woo Yong, Choe, Won Joo, Orestes, Peihan, Latham, Janelle R., Todorovic, Slobodan M., Jevtovic-Todorovic, Vesna

“…Earlier, we showed that streptozocin (STZ)-induced type 1 diabetes in rats leads to the development of painful peripheral diabetic neuropathy (PDN) manifested…”
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In vivo silencing of the Ca(V)3.2 T-type calcium channels in sensory neurons alleviates hyperalgesia in rats with streptozocin-induced diabetic neuropathy by Messinger, Richard B, Naik, Ajit K, Jagodic, Miljen M, Nelson, Michael T, Lee, Woo Yong, Choe, Won Joo, Orestes, Peihan, Latham, Janelle R, Todorovic, Slobodan M, Jevtovic-Todorovic, Vesna

“…Earlier, we showed that streptozocin (STZ)-induced type 1 diabetes in rats leads to the development of painful peripheral diabetic neuropathy (PDN) manifested…”
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Glycosylation of Ca V 3.2 Channels Contributes to the Hyperalgesia in Peripheral Neuropathy of Type 1 Diabetes by Joksimovic, Sonja Lj, Evans, J Grayson, McIntire, William E, Orestes, Peihan, Barrett, Paula Q, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…Our previous studies implicated glycosylation of the Ca 3.2 isoform of T-type Ca channels (T-channels) in the development of Type 2 painful peripheral diabetic…”
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Molecular Mechanisms of Lipoic Acid Modulation of T-Type Calcium Channels in Pain Pathway by Lee, Woo Yong, Orestes, Peihan, Latham, Janelle, Naik, Ajit K, Nelson, Michael T, Vitko, Iuliia, Perez-Reyes, Edward, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…Alpha-lipoic acid (1,2-dithiolane-3-pentanoic acid; lipoic acid) is an endogenous compound used to treat pain disorders in humans, but its mechanisms of…”
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Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca(v)2.3 calcium channels by Shcheglovitov, Aleksandr, Vitko, Iuliia, Lazarenko, Roman M, Orestes, Peihan, Todorovic, Slobodan M, Perez-Reyes, Edward

“…Here, we describe a new mechanism by which glutamate (Glu) and trace metals reciprocally modulate activity of the Ca(v)2.3 channel by profoundly shifting its…”
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Free radical signalling underlies inhibition of CaV3.2 T‐type calcium channels by nitrous oxide in the pain pathway by Orestes, Peihan, Bojadzic, Damir, Lee, JeongHan, Leach, Emily, Salajegheh, Reza, DiGruccio, Michael R., Nelson, Michael T., Todorovic, Slobodan M.

“…Non‐technical summary Nitrous oxide (N2O) has long been used as a pain reliever, but little is known of its targets in the body. We show that N2O indirectly…”
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Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Cav2.3 calcium channels by Shcheglovitov, Aleksandr, Vitko, Iuliia, Lazarenko, Roman M., Orestes, Peihan, Todorovic, Slobodan M., Perez-Reyes, Edward

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Molecular and biophysical basis of glutamate and trace metal modulation of voltage-gated Ca^sub v^2.3 calcium channels by Shcheglovitov, Aleksandr, Vitko, Iuliia, Lazarenko, Roman M, Orestes, Peihan, Todorovic, Slobodan M, Perez-Reyes, Edward

“…Here, we describe a new mechanism by which glutamate (Glu) and trace metals reciprocally modulate activity of the ... channel by profoundly shifting its…”
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TRPV1-lineage neurons are required for thermal sensation: TRPV1-lineage neurons by Mishra, Santosh K, Tisel, Sarah M, Orestes, Peihan, Bhangoo, Sonia K, Hoon, Mark A

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Free radical signalling underlies inhibition of Ca V 3.2 T‐type calcium channels by nitrous oxide in the pain pathway by Orestes, Peihan, Bojadzic, Damir, Lee, JeongHan, Leach, Emily, Salajegheh, Reza, DiGruccio, Michael R., Nelson, Michael T., Todorovic, Slobodan M.

“…Non‐technical summary Nitrous oxide (N 2 O) has long been used as a pain reliever, but little is known of its targets in the body. We show that N 2 O…”
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Reversal of neuropathic pain in diabetes by targeting glycosylation of [Ca.sub.v]3.2 T-type calcium channels.(ORIGINAL ARTICLE) by Orestes, Peihan, Osuru, Hari Prasad, McIntire, William E, Jacus, Megan O, Salajegheh, Reza, Jagodic, Miljen M, Choe, WonJoo, Lee, JeongHan, Lee, Sang-Soo, Rose, Kirstin E, Poiro, Nathan, DiGruccio, Michael R, Krishnan, Katiresan, Covey, Douglas F, Lee, Jung-Ha, Barrett, Paula Q, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…It has been established that [Ca.sub.v]3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of…”
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Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Ca^sub v^3.2 T-Type Calcium Channels by Orestes, Peihan, Osuru, Hari Prasad, McIntire, William E, Jacus, Megan O, Salajegheh, Reza, Jagodic, Miljen M, Choe, WonJoo, Lee, JeongHan, Lee, Sang-Soo, Rose, Kirstin E, Poiro, Nathan, DiGruccio, Michael R, Krishnan, Katiresan, Covey, Douglas F, Lee, Jung-Ha, Barrett, Paula Q, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…It has been established that CaV3.2 T-type voltage-gated calcium channels (T-channels) play a key role in the sensitized (hyperexcitable) state of nociceptive…”
Get full text