Search Results - "Orengo, CA"

CATH – a hierarchic classification of protein domain structures by Orengo, CA, Michie, AD, Jones, S, Jones, DT, Swindells, MB, Thornton, JM

“…Background: Protein evolution gives rise to families of structurally related proteins, within which sequence identities can be extremely low. As a result,…”
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Protein families and their evolution-a structural perspective by Orengo, Christine A, Thornton, Janet M

“…We can now assign about two thirds of the sequences from completed genomes to as few as 1400 domain families for which structures are known and thus more…”
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Protein function prediction – the power of multiplicity by Rentzsch, Robert, Orengo, Christine A

“…Advances in experimental and computational methods have quietly ushered in a new era in protein function annotation. This ‘age of multiplicity’ is marked by…”
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One Fold with Many Functions: The Evolutionary Relationships between TIM Barrel Families Based on their Sequences, Structures and Functions by Nagano, Nozomi, Orengo, Christine A, Thornton, Janet M

“…The eightfold (βα) barrel structure, first observed in triose-phosphate isomerase, occurs ubiquitously in nature. It is nearly always an enzyme and most often…”
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Evolution of function in protein superfamilies, from a structural perspective by Todd, A E, Orengo, C A, Thornton, J M

“…The recent growth in protein databases has revealed the functional diversity of many protein superfamilies. We have assessed the functional variation of…”
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Progress of Structural Genomics Initiatives: An Analysis of Solved Target Structures by Todd, Annabel E., Marsden, Russell L., Thornton, Janet M., Orengo, Christine A.

“…The explosion in gene sequence data and technological breakthroughs in protein structure determination inspired the launch of structural genomics (SG)…”
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The CATH database: an extended protein family resource for structural and functional genomics by Pearl, F. M. G., Bennett, C. F., Bray, J. E., Harrison, A. P., Martin, N., Shepherd, A., Sillitoe, I., Thornton, J., Orengo, C. A.

“…The CATH database of protein domain structures (http://www.biochem.ucl.ac.uk/bsm/cath_new) currently contains 34 287 domain structures classified into 1383…”
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FFPred: an integrated feature-based function prediction server for vertebrate proteomes by Lobley, A.E, Nugent, T, Orengo, C.A, Jones, D.T

“…One of the challenges of the post-genomic era is to provide accurate function annotations for large volumes of data resulting from genome sequencing projects…”
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Plasticity of enzyme active sites by Todd, Annabel E., Orengo, Christine A., Thornton, Janet M.

“…The expectation is that any similarity in reaction chemistry shared by enzyme homologues is mediated by common functional groups conserved through evolution…”
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Combining sensitive database searches with multiple intermediates to detect distant homologues by Salamov, Asaf A., Suwa, Makiko, Orengo, Christine A., Swindells, Mark B.

“…Using data from the CATH structure classification, we have assessed the blastp, fasta, smith–waterman and gapped-blast algorithms, developed a portable…”
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Sequence and Structural Differences between Enzyme and Nonenzyme Homologs by Todd, Annabel E, Orengo, Christine A, Thornton, Janet M

“…To improve our understanding of the evolution of novel functions, we performed a sequence, structural, and functional analysis of homologous enzymes and…”
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From structure to function: approaches and limitations by Thornton, J M, Todd, A E, Milburn, D, Borkakoti, N, Orengo, C A

“…This review presents a summary of current approaches to extract functional information from structural data on proteins and their complexes. While structural…”
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Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space by Marsden, Russell L., Lee, David, Maibaum, Michael, Yeats, Corin, Orengo, Christine A.

“…We present an analysis of 203 completed genomes in the Gene3D resource (including 17 eukaryotes), which demonstrates that the number of protein families is…”
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One session cognitive behavioural therapy for elderly patients with chronic obstructive pulmonary disease by Kunik, M E, Braun, U, Stanley, M A, Wristers, K, Molinari, V, Stoebner, D, Orengo, C A

“…We hypothesized that compared to an educational intervention, a single 2 h session of cognitive behavioural therapy (CBT), with 6-week follow-up, would reduce…”
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Evolution of Protein Superfamilies and Bacterial Genome Size by Ranea, Juan A.G., Buchan, Daniel W.A., Thornton, Janet M., Orengo, Christine A.

“…We present the structural annotation of 56 different bacterial species based on the assignment of genes to 816 evolutionary superfamilies in the CATH domain…”
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From protein structure to function by Orengo, Christine A, Todd, Annabel E, Thornton, Janet M

“…Several databases of protein structural families now exist —organised according to both evolutionary relationships and common folding arrangements. Although…”
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Protein superfamilies and domain superfolds by Orengo, C.A, Jones, D.T, Thornton, J.M

“…As the protein sequence and structure databases expand rapidly a better understanding of the relationships between proteins is required. A classification is…”
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SSAP: sequential structure alignment program for protein structure comparison by Orengo, C A, Taylor, W R

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Accuracy of Self-Reported Depression in Persons with Dementia by Snow, A. Lynn, Kunik, Mark E., Molinari, Victor A., Orengo, Claudia A., Doody, Rachelle, Graham, David P., Norris, Margaret P.

“…Objectives: To investigate the reliability and validity of self‐reported depression in demented elderly patients. Design: This is the first study to combine…”
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Safety and Efficacy of Testosterone Gel 1% Augmentation in Depressed Men With Partial Response to Antidepressant Therapy by Orengo, Claudia A., Fullerton, Laura, Kunik, Mark E.

“…The current study evaluates the efficacy and safety of testosterone (T) gel 1% augmentation on depressive symptoms and quality of life in treatment-resistant,…”
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