Search Results - "Orellana, Manuel"

Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia by Sánchez-Martínez, Diego, Baroni, Matteo L., Gutierrez-Agüera, Francisco, Roca-Ho, Heleia, Blanch-Lombarte, Oscar, González-García, Sara, Torrebadell, Montserrat, Junca, Jordi, Ramírez-Orellana, Manuel, Velasco-Hernández, Talía, Bueno, Clara, Fuster, José Luís, Prado, Julia G., Calvo, Julien, Uzan, Benjamin, Cools, Jan, Camos, Mireia, Pflumio, Françoise, Toribio, María Luisa, Menéndez, Pablo

“…Relapsed/refractory T-cell acute lymphoblastic leukemia (T-ALL) has a dismal outcome, and no effective targeted immunotherapies for T-ALL exist. The extension…”
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A Mathematical Description of the Bone Marrow Dynamics during CAR T-Cell Therapy in B-Cell Childhood Acute Lymphoblastic Leukemia by Martínez-Rubio, Álvaro, Chulián, Salvador, Blázquez Goñi, Cristina, Ramírez Orellana, Manuel, Pérez Martínez, Antonio, Navarro-Zapata, Alfonso, Ferreras, Cristina, Pérez-García, Victor M, Rosa, María

“…Chimeric Antigen Receptor (CAR) T-cell therapy has demonstrated high rates of response in recurrent B-cell Acute Lymphoblastic Leukemia in children and young…”
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The shape of cancer relapse: Topological data analysis predicts recurrence in paediatric acute lymphoblastic leukaemia by Chulián, Salvador, Stolz, Bernadette J, Martínez-Rubio, Álvaro, Blázquez Goñi, Cristina, Rodríguez Gutiérrez, Juan F, Caballero Velázquez, Teresa, Molinos Quintana, Águeda, Ramírez Orellana, Manuel, Castillo Robleda, Ana, Fuster Soler, José Luis, Minguela Puras, Alfredo, Martínez Sánchez, María V, Rosa, María, Pérez-García, Víctor M, Byrne, Helen M

“…Although children and adolescents with acute lymphoblastic leukaemia (ALL) have high survival rates, approximately 15-20% of patients relapse. Risk of relapse…”
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Clinical and financial outcomes of hospitalizations for cardiac device infection during the COVID-19 pandemic in the US by Ascandar, Nameer, Chervu, Nikhil, Bakhtiyar, Syed Shahyan, Cho, Nam Yong, Kim, Shineui, Orellana, Manuel, Benharash, Peyman

“…Background Cardiac device infection (CDI) can occur in up to 2.2% of patients after device placement, with mortality rates exceeding 15%. Although device…”
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Association of hospital volume with conversion to open from minimally invasive colectomy in patients with diverticulitis: A national analysis by Ebrahimian, Shayan, Verma, Arjun, Sakowitz, Sara, Olmedo, Manuel Orellana, Chervu, Nikhil, Khan, Aimal, Hawkins, Alexander, Benharash, Peyman, Lee, Hanjoo

“…Despite the known advantages of minimally invasive surgery (MIS) for diverticular disease, the impact of conversions to open (CtO) colectomy remains…”
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TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia by Bueno, Clara, Martínez, Alba, Romecin, Paola Alejandra, Zanetti, Samanta Romina, Tirtakusuma, Ricky, Genesca, Eulalia, Camós, Mireia, Ramírez-Orellana, Manuel, Anguita, Eduardo, Ballerini, Paola, Locatelli, Franco, Fuster, José Luis, Menéndez, Pablo

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Immune stress suppresses innate immune signaling in preleukemic precursor B-cells to provoke leukemia in predisposed mice by Isidro-Hernández, Marta, Casado-García, Ana, Oak, Ninad, Alemán-Arteaga, Silvia, Ruiz-Corzo, Belén, Martínez-Cano, Jorge, Mayado, Andrea, Sánchez, Elena G., Blanco, Oscar, Gaspar, Ma Luisa, Orfao, Alberto, Alonso-López, Diego, De Las Rivas, Javier, Riesco, Susana, Prieto-Matos, Pablo, González-Murillo, África, Criado, Francisco Javier García, Cenador, María Begoña García, Ramírez-Orellana, Manuel, de Andrés, Belén, Vicente-Dueñas, Carolina, Cobaleda, César, Nichols, Kim E., Sánchez-García, Isidro

“…The initial steps of B-cell acute lymphoblastic leukemia (B-ALL) development usually pass unnoticed in children. Several preclinical studies have shown that…”
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Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia by Tejedor, Juan Ramón, Bueno, Clara, Vinyoles, Meritxell, Petazzi, Paolo, Agraz-Doblas, Antonio, Cobo, Isabel, Torres-Ruiz, Raúl, Bayón, Gustavo F, Pérez, Raúl F, López-Tamargo, Sara, Gutierrez-Agüera, Francisco, Santamarina-Ojeda, Pablo, Ramírez-Orellana, Manuel, Bardini, Michela, Cazzaniga, Giovanni, Ballerini, Paola, Schneider, Pauline, Stam, Ronald W, Varela, Ignacio, Fraga, Mario F, Fernández, Agustín F, Menéndez, Pablo

“…B cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. As predicted by its prenatal origin, infant B-ALL (iB-ALL) shows an…”
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Backtracking NOM1::ETV6 fusion to neonatal pathogenesis of t(7;12) (q36;p13) infant AML by Bousquets-Muñoz, Pablo, Molina, Oscar, Varela, Ignacio, Álvarez-Eguiluz, Ángel, Fernández-Mateos, Javier, Gómez, Ana, Sánchez, Elena G., Balbín, Milagros, Ruano, David, Ramírez-Orellana, Manuel, Puente, Xose S., Menéndez, Pablo, Velasco-Hernandez, Talia

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Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high‐hyperdiploid B‐cell acute lymphoblastic leukemia by Ramos‐Muntada, Mireia, Trincado, Juan L., Blanco, Joan, Bueno, Clara, Rodríguez‐Cortez, Virginia C., Bataller, Alex, López‐Millán, Belén, Schwab, Claire, Ortega, Margarita, Velasco, Pablo, Blanco, Maria L., Nomdedeu, Josep, Ramírez‐Orellana, Manuel, Minguela, Alfredo, Fuster, Jose L., Cuatrecasas, Esther, Camós, Mireia, Ballerini, Paola, Escherich, Gabriele, Boer, Judith, DenBoer, Monique, Hernández‐Rivas, Jesús M., Calasanz, Maria J., Cazzaniga, Giovanni, Harrison, Christine J., Menéndez, Pablo, Molina, Oscar

“…B‐cell acute lymphoblastic leukemia (B‐ALL) is the commonest childhood cancer. High hyperdiploidy (HHD) identifies the most frequent cytogenetic subgroup in…”
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sRAGE as severe acute bronchiolitis biomarker, prospective observational study by Sierra‐Colomina, Montserrat, García‐Salido, Alberto, Leoz‐Gordillo, Inés, Martínez de Azagra‐Garde, Amelia, Melen, Gustavo, García‐Teresa, María Ángeles, Iglesias‐Bouzas, Mabel, Nieto‐Moro, Montserrat, Ramírez‐Orellana, Manuel, Serrano‐González, Ana

“…Introduction and Objectives Acute bronchiolitis (AB) is the leading cause of hospitalization in infants and around 5% require intensive care treatment. Early…”
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Mesenchymal stromal cells derived from the bone marrow of acute lymphoblastic leukemia patients show altered BMP4 production: correlations with the course of disease by Vicente López, Ángeles, Vázquez García, Miriam Nohemí, Melen, Gustavo J, Entrena Martínez, Ana, Cubillo Moreno, Isabel, García-Castro, Javier, Orellana, Manuel Ramírez, González, Agustín Gregorio Zapata

“…The relevance of tumor microenvironment for the development and progression of tumor cells in hematological malignancies has been extensively reported…”
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Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach by Chulián, Salvador, Martínez-Rubio, Álvaro, Marciniak-Czochra, Anna, Stiehl, Thomas, Goñi, Cristina Blázquez, Rodríguez Gutiérrez, Juan Francisco, Ramírez Orellana, Manuel, Castillo Robleda, Ana, Pérez-García, Víctor M., Rosa, María

“…•B lymphopoiesis is a regulated process that leads to the formation of B cells.•We describe a compartmental mathematical model of feedback signalling for B…”
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Perianal Abscess Following Excisional Hemorrhoidectomy in an Immunocompetent Patient by Orellana Olmedo, Manuel A, Lee, Hanjoo

“…Hemorrhoidal disease is the third most common outpatient gastrointestinal diagnosis affecting more than four million patients annually. The management depends…”
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Off-label mesenchymal stromal cell treatment in two infants with severe bronchopulmonary dysplasia: clinical course and biomarkers profile by Álvarez-Fuente, María, Arruza, Luis, Lopez-Ortego, Paloma, Moreno, Laura, Ramírez-Orellana, Manuel, Labrandero, Carlos, González, África, Melen, Gustavo, Cerro, Maria Jesús Del

“…Highlights • First report of intravenous administration of MSCs in preterm babies. • First report of the use of repeated, multiple doses of MSCs in human…”
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Dual-Target CAR-Ts with On- and Off-Tumour Activity May Override Immune Suppression in Solid Cancers: A Mathematical Proof of Concept by León-Triana, Odelaisy, Pérez-Martínez, Antonio, Ramírez-Orellana, Manuel, Pérez-García, Víctor M

“…Chimeric antigen receptor (CAR)-T cell-based therapies have achieved substantial success against B-cell malignancies, which has led to a growing scientific and…”
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Revisiting the concept of childhood preleukemia by Cobaleda, Cesar, Vicente-Dueñas, Carolina, Ramírez-Orellana, Manuel, Sanchez-Garcia, Isidro

“…Preleukemic has been used to describe children with a propensity to develop B cell acute lymphoblastic leukemia (B-ALL). However, leukemia-predisposing…”
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Transient Inhibition of the JAK/STAT Pathway Prevents B-ALL Development in Genetically Predisposed Mice by Casado-García, Ana, Isidro-Hernández, Marta, Oak, Ninad, Mayado, Andrea, Mann-Ran, Christine, Raboso-Gallego, Javier, Alemán-Arteaga, Silvia, Buhles, Alexandra, Sterker, Dario, Sánchez, Elena G, Martínez-Cano, Jorge, Blanco, Oscar, Orfao, Alberto, Alonso-López, Diego, De Las Rivas, Javier, Riesco, Susana, Prieto-Matos, Pablo, González-Murillo, África, García Criado, Francisco Javier, García Cenador, María Begoña, Radimerski, Thomas, Ramírez-Orellana, Manuel, Cobaleda, César, Yang, Jun J, Vicente-Dueñas, Carolina, Weiss, Andreas, Nichols, Kim E, Sánchez-García, Isidro

“…Preventing development of childhood B-cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects, is a longstanding and unsolved challenge…”
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CD64 on monocytes and granulocytes in severe acute bronchiolitis: Pilot study on its usefulness as a bacterial infection biomarker by García‐Salido, Alberto, Serrano‐González, Ana, Casado‐Flores, Juan, Sierra‐Colomina, Montserrat, Azagra‐Garde, Amelia Martínez, García‐Teresa, María Ángeles, Melen, Gustavo J., Ramírez‐Orellana, Manuel

“…The CD64 receptor has been described as a biomarker of bacterial infection. We speculated that CD64 surface expression on monocytes and granulocytes of…”
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Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL by Molina, Oscar, Vinyoles, Meritxell, Granada, Isabel, Roca-Ho, Heleia, Gutierrez-Agüera, Francisco, Valledor, Luis, López-López, Carlos M., Rodríguez-González, Pablo, Trincado, Juan L., Menéndez, Sofía T., Pal, Deepali, Ballerini, Paola, den Boer, Monique L., Plensa, Isabel, Mar Perez-Iribarne, M., Rodríguez-Perales, Sandra, Calasanz, María José, Ramírez-Orellana, Manuel, Rodríguez, René, Camós, Mireia, Calvo, Maria, Bueno, Clara, Menéndez, Pablo

“…B-cell acute lymphoblastic leukemia (ALL; B-ALL) is the most common pediatric cancer, and high hyperdiploidy (HyperD) identifies the most common subtype of…”
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