Search Results - "Orellana, Juan"

Hemichannels: new roles in astroglial function by Orellana, Juan A, Stehberg, Jimmy

“…The role of astrocytes in brain function has evolved over the last decade, from support cells to active participants in the neuronal synapse through the…”
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ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels by Orellana, Juan A., Froger, Nicolas, Ezan, Pascal, Jiang, Jean X., Bennett, Michael V. L., Naus, Christian C., Giaume, Christian, Sáez, Juan C.

“…J. Neurochem. (2011) 118, 826–840. Inflammation contributes to neurodegeneration in post‐ischemic brain, diabetes, and Alzheimer’s disease. Participants in…”
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Connexin and pannexin hemichannels in inflammatory responses of glia and neurons by Bennett, Michael V.L, Garré, Juan M, Orellana, Juan A, Bukauskas, Felix F, Nedergaard, Maiken, Giaume, Christian, Sáez, Juan C

“…Abstract Mammals express ∼20 different connexins, the main gap junction forming proteins in mammals, and 3 pannexins, homologs of innexins, the main gap…”
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Gap junction channels and hemichannels in the CNS: Regulation by signaling molecules by Orellana, Juan A., Martinez, Agustín D., Retamal, Mauricio A.

“…Coordinated interaction among cells is critical to develop the extremely complex and dynamic tasks performed by the central nervous system (CNS). Cell…”
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Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala by Stehberg, Jimmy, Moraga‐Amaro, Rodrigo, Salazar, Christian, Becerra, Alvaro, Echeverría, Cesar, Orellana, Juan A., Bultynck, Geert, Ponsaerts, Raf, Leybaert, Luc, Simon, Felipe, Sáez, Juan C., Retamal, Mauricio A.

“…Recent in vitro evidence indicates that astrocytes can modulate synaptic plasticity by releasing neuroactive substances (gliotransmitters). However, whether…”
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Amyloid β-induced death in neurons involves glial and neuronal hemichannels by Orellana, Juan A, Shoji, Kenji F, Abudara, Verónica, Ezan, Pascal, Amigou, Edwige, Sáez, Pablo J, Jiang, Jean X, Naus, Christian C, Sáez, Juan C, Giaume, Christian

“…The mechanisms involved in Alzheimer's disease are not completely understood and how glial cells contribute to this neurodegenerative disease remains to be…”
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Astrocytes inhibit nitric oxide-dependent Ca2+ dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels by Orellana, Juan A., Montero, Trinidad D., von Bernhardi, Rommy

“…Under inflammatory conditions, microglia exhibit increased levels of free intracellular Ca2+ and produce high amounts of nitric oxide (NO). However, whether…”
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Glial connexin expression and function in the context of Alzheimer's disease by Koulakoff, Annette, Mei, Xin, Orellana, Juan A., Sáez, Juan C., Giaume, Christian

“…A hallmark of neurodegenerative diseases is the reactive gliosis characterized by a phenotypic change in astrocytes and microglia. This glial response is…”
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Synaptic Functions of Hemichannels and Pannexons: A Double-Edged Sword by Abudara, Verónica, Retamal, Mauricio A, Del Rio, Rodrigo, Orellana, Juan A

“…The classical view of synapses as the functional contact between presynaptic and postsynaptic neurons has been challenged in recent years by the emerging…”
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Hypertensive Nephropathy: Unveiling the Possible Involvement of Hemichannels and Pannexons by Lucero, Claudia M, Prieto-Villalobos, Juan, Marambio-Ruiz, Lucas, Balmazabal, Javiera, Alvear, Tanhia F, Vega, Matías, Barra, Paola, Retamal, Mauricio A, Orellana, Juan A, Gómez, Gonzalo I

“…Hypertension is one of the most common risk factors for developing chronic cardiovascular diseases, including hypertensive nephropathy. Within the glomerulus,…”
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Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: involvement of ATP released via pannexin 1 channels by Orellana, Juan A, Montero, Trinidad D, von Bernhardi, Rommy

“…Under inflammatory conditions, microglia exhibit increased levels of free intracellular Ca(2+) and produce high amounts of nitric oxide (NO). However, whether…”
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HIV gp120 Protein Increases the Function of Connexin 43 Hemichannels and Pannexin-1 Channels in Astrocytes: Repercussions on Astroglial Function by Gajardo-Gómez, Rosario, Santibañez, Cristian A, Labra, Valeria C, Gómez, Gonzalo I, Eugenin, Eliseo A, Orellana, Juan A

“…At least half of human immunodeficiency virus (HIV)-infected individuals suffer from a wide range of cognitive, behavioral and motor deficits, collectively…”
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Connexin 43 hemichannels and pannexin‐1 channels contribute to the α‐synuclein‐induced dysfunction and death of astrocytes by Díaz, Esteban F., Labra, Valeria C., Alvear, Tanhia F., Mellado, Luis A., Inostroza, Carla A., Oyarzún, Juan E., Salgado, Nicole, Quintanilla, Rodrigo A., Orellana, Juan A.

“…Diverse studies have suggested that cytoplasmic inclusions of misfolded α‐synuclein in neuronal and glial cells are main pathological features of different…”
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Connexins and Pannexins: New Insights into Microglial Functions and Dysfunctions by Gajardo-Gómez, Rosario, Labra, Valeria C, Orellana, Juan A

“…Under physiological conditions, microglia adopt a resting phenotype associated with the production of anti-inflammatory and neurotrophic factors. In response…”
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Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels by Orellana, Juan A., Hernández, Diego E., Ezan, Pascal, Velarde, Victoria, Bennett, Michael V. L., Giaume, Christian, Sáez, Juan C.

“…Brain ischemia causes more extensive injury in hyperglycemic than normoglycemic subjects, and the increased damage is to astroglia as well as neurons. In the…”
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Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage by Sáez, Juan C., Contreras-Duarte, Susana, Labra, Valeria C., Santibañez, Cristian A., Mellado, Luis A., Inostroza, Carla A., Alvear, Tanhia F., Retamal, Mauricio A., Velarde, Victoria, Orellana, Juan A.

“…Both IFN-γ or high glucose have been linked to systemic inflammatory imbalance with serious repercussions not only for endothelial function but also for the…”
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Glucose increases intracellular free Ca2+ in tanycytes via ATP released through connexin 43 hemichannels by Orellana, Juan A., Sáez, Pablo J., Cortés-campos, Christian, Elizondo, Roberto J., Shoji, Kenji F., Contreras-Duarte, Susana, Figueroa, Vania, Velarde, Victoria, Jiang, Jean X., Nualart, Francisco, Sáez, Juan C., García, María A.

“…The ventromedial hypothalamus is involved in regulating feeding and satiety behavior, and its neurons interact with specialized ependymal‐glial cells, termed…”
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Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival by Avendaño, Beatriz C., Montero, Trinidad D., Chávez, Carolina E., von Bernhardi, Rommy, Orellana, Juan A.

“…Several epidemiological studies indicate that children born from mothers exposed to infections during gestation, have an increased risk to develop neurological…”
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GABAergic Regulation of Astroglial Gliotransmission through Cx43 Hemichannels by Jiménez-Dinamarca, Ivanka, Reyes-Lizana, Rachel, Lemunao-Inostroza, Yordan, Cárdenas, Kevin, Castro-Lazo, Raimundo, Peña, Francisca, Lucero, Claudia M., Prieto-Villalobos, Juan, Retamal, Mauricio Antonio, Orellana, Juan Andrés, Stehberg, Jimmy

“…Gamma-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. It is produced by interneurons and recycled by astrocytes. In neurons,…”
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Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala by Linsambarth, Sergio, Carvajal, Francisco J., Moraga‐Amaro, Rodrigo, Mendez, Luis, Tamburini, Giovanni, Jimenez, Ivanka, Verdugo, Daniel Antonio, Gómez, Gonzalo I., Jury, Nur, Martínez, Pablo, Zundert, Brigitte, Varela‐Nallar, Lorena, Retamal, Mauricio A., Martin, Claire, Altenberg, Guillermo A., Fiori, Mariana C., Cerpa, Waldo, Orellana, Juan A., Stehberg, Jimmy

“…Astrocytes release gliotransmitters via connexin 43 (Cx43) hemichannels into neighboring synapses, which can modulate synaptic activity and are necessary for…”
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