Search Results - "Orekhov, Alexander N"

The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation by Poznyak, Anastasia, Grechko, Andrey V, Poggio, Paolo, Myasoedova, Veronika A, Alfieri, Valentina, Orekhov, Alexander N

“…Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of…”
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Macrophage‐mediated cholesterol handling in atherosclerosis by Chistiakov, Dimitry A., Bobryshev, Yuri V., Orekhov, Alexander N.

“…Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes attracted by pro‐inflammatory stimuli attach to the inflamed vascular…”
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LDL and foam cell formation as the basis of atherogenesis by Orekhov, Alexander N

“…Lipoprotein-induced intracellular lipid accumulation (foam cell formation) is a trigger of atherogenesis at the subendothelial arterial cell level. The purpose…”
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Mechanisms of foam cell formation in atherosclerosis by Chistiakov, Dimitry A., Melnichenko, Alexandra A., Myasoedova, Veronika A., Grechko, Andrey V., Orekhov, Alexander N.

“…Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express…”
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The role of mitochondrial dysfunction in cardiovascular disease: a brief review by Chistiakov, Dimitry A, Shkurat, Tatiana P, Melnichenko, Alexandra A, Grechko, Andrey V, Orekhov, Alexander N

“…Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Proper mitochondrial function is necessary in tissues and organs that are of high…”
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Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis by Poznyak, Anastasia V, Nikiforov, Nikita G, Markin, Alexander M, Kashirskikh, Dmitry A, Myasoedova, Veronika A, Gerasimova, Elena V, Orekhov, Alexander N

“…Cardiovascular pathologies maintain the leading position in mortality worldwide. Atherosclerosis is a chronic disease that can result in a variety of serious…”
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The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease by Chistiakov, Dimitry A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Abstract Expression of microRNA (miR)-126 is enriched in endothelial cells (ECs) and endothelial progenitor cells (EPCs). MiR-126 is considered a master…”
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The role of mitochondria dysfunction and hepatic senescence in NAFLD development and progression by Dabravolski, Siarhei A., Bezsonov, Evgeny E., Orekhov, Alexander N.

“…Senescence is a crucial player in several metabolic disorders and chronic inflammatory diseases. Recent data prove the involvement of hepatocyte senescence in…”
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Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases by Grechko, Andrey V., Melnichenko, Alexandra A., Myasoedova, Veronika A., Ivanova, Ekaterina A., Orekhov, Alexander N.

“…Low-density lipoprotein (LDL) plays a key role in the development and progression of atherosclerosis and cardiovascular disease. LDL consists of several…”
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Molecular Aspects of Inflammation and Lipid Metabolism in Health and Disease: The Role of the Mitochondria by Sukhorukov, Vasily N, Orekhov, Alexander N

“…Inflammation and lipid metabolism are two deeply interconnected and reciprocally regulated major physiological processes [...]…”
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Sex-Specific Features of Calcific Aortic Valve Disease by Summerhill, Volha I, Moschetta, Donato, Orekhov, Alexander N, Poggio, Paolo, Myasoedova, Veronika A

“…Calcific aortic valve disease (CAVD) is the most common valvular heart disease in developed countries predominantly affecting the elderly population therefore…”
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Endothelial Barrier and Its Abnormalities in Cardiovascular Disease by Chistiakov, Dimitry A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular wall. In addition, the endothelium is highly metabolically active. In…”
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The Atherogenic Role of Circulating Modified Lipids in Atherosclerosis by Summerhill, Volha I, Grechko, Andrey V, Yet, Shaw-Fang, Sobenin, Igor A, Orekhov, Alexander N

“…Lipid accumulation in the arterial wall is a crucial event in the development of atherosclerotic lesions. Circulating low-density lipoprotein (LDL) is the…”
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Mitochondrial Aging and Age-Related Dysfunction of Mitochondria by Orekhov, Alexander N., Sobenin, Igor A., Revin, Victor V., Bobryshev, Yuri V., Chistiakov, Dimitry A.

“…Age-related changes in mitochondria are associated with decline in mitochondrial function. With advanced age, mitochondrial DNA volume, integrity and…”
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Renin-Angiotensin System in Pathogenesis of Atherosclerosis and Treatment of CVD by Poznyak, Anastasia V., Bharadwaj, Dwaipayan, Prasad, Gauri, Grechko, Andrey V., Sazonova, Margarita A., Orekhov, Alexander N.

“…Atherosclerosis has complex pathogenesis, which involves at least three serious aspects: inflammation, lipid metabolism alterations, and endothelial injury…”
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Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling by Bobryshev, Yuri V., Orekhov, Alexander N., Sobenin, Igor A., Chistiakov, Dimitry A.

“…A cluster of miR-221/222 is a key player in vascular biology through exhibiting its effects on vascular smooth muscle cells (VSMCs) and endothelial cells…”
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Changes in transcriptome of macrophages in atherosclerosis by Chistiakov, Dimitry A., Bobryshev, Yuri V., Orekhov, Alexander N.

“…Macrophages display significant phenotypic heterogeneity. Two growth factors, macrophage colony‐stimulating factor and chemokine (C‐X‐C motif) ligand 4, drive…”
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Mitochondrial Dysfunction and Chronic Inflammation in Polycystic Ovary Syndrome by Dabravolski, Siarhei A, Nikiforov, Nikita G, Eid, Ali H, Nedosugova, Ludmila V, Starodubova, Antonina V, Popkova, Tatyana V, Bezsonov, Evgeny E, Orekhov, Alexander N

“…Polycystic ovarian syndrome (PCOS) is the most common endocrine-metabolic disorder affecting a vast population worldwide; it is linked with anovulation,…”
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The Role of the VEGF Family in Atherosclerosis Development and Its Potential as Treatment Targets by Dabravolski, Siarhei A, Khotina, Victoria A, Omelchenko, Andrey V, Kalmykov, Vladislav A, Orekhov, Alexander N

“…The vascular endothelial growth factor (VEGF) family, the crucial regulator of angiogenesis, lymphangiogenesis, lipid metabolism and inflammation, is involved…”
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The Role of Endoplasmic Reticulum Stress and Unfolded Protein Response in Atherosclerosis by Ivanova, Ekaterina A, Orekhov, Alexander N

“…Pathogenesis of atherosclerosis is a complex process involving several metabolic and signalling pathways. Accumulating evidence demonstrates that endoplasmic…”
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