Search Results - "Orekhov, Alexander"

The Diabetes Mellitus-Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation by Poznyak, Anastasia, Grechko, Andrey V, Poggio, Paolo, Myasoedova, Veronika A, Alfieri, Valentina, Orekhov, Alexander N

“…Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a common main feature of chronic hyperglycemia that results from defects of…”
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Macrophage‐mediated cholesterol handling in atherosclerosis by Chistiakov, Dimitry A., Bobryshev, Yuri V., Orekhov, Alexander N.

“…Formation of foam cells is a hallmark at the initial stages of atherosclerosis. Monocytes attracted by pro‐inflammatory stimuli attach to the inflamed vascular…”
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LDL and foam cell formation as the basis of atherogenesis by Orekhov, Alexander N

“…Lipoprotein-induced intracellular lipid accumulation (foam cell formation) is a trigger of atherogenesis at the subendothelial arterial cell level. The purpose…”
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The Role of Endoplasmic Reticulum Stress and Unfolded Protein Response in Atherosclerosis by Ivanova, Ekaterina A, Orekhov, Alexander N

“…Pathogenesis of atherosclerosis is a complex process involving several metabolic and signalling pathways. Accumulating evidence demonstrates that endoplasmic…”
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Cardiac Extracellular Vesicles in Normal and Infarcted Heart by Chistiakov, Dimitry A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Heart is a complex assembly of many cell types constituting myocardium, endocardium and epicardium that intensively communicate to each other in order to…”
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Cardiac-specific miRNA in cardiogenesis, heart function, and cardiac pathology (with focus on myocardial infarction) by Chistiakov, Dimitry A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Abstract Cardiac miRNAs (miR-1, miR133a, miR-208a/b, and miR-499) are abundantly expressed in the myocardium. They play a central role in cardiogenesis, heart…”
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Mechanisms of foam cell formation in atherosclerosis by Chistiakov, Dimitry A., Melnichenko, Alexandra A., Myasoedova, Veronika A., Grechko, Andrey V., Orekhov, Alexander N.

“…Low-density lipoprotein (LDL) and cholesterol homeostasis in the peripheral blood is maintained by specialized cells, such as macrophages. Macrophages express…”
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The role of mitochondrial dysfunction in cardiovascular disease: a brief review by Chistiakov, Dimitry A, Shkurat, Tatiana P, Melnichenko, Alexandra A, Grechko, Andrey V, Orekhov, Alexander N

“…Cardiovascular disease (CVD) is a leading cause of mortality worldwide. Proper mitochondrial function is necessary in tissues and organs that are of high…”
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CD68/macrosialin: not just a histochemical marker by Chistiakov, Dimitry A, Killingsworth, Murry C, Myasoedova, Veronika A, Orekhov, Alexander N, Bobryshev, Yuri V

“…CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and other mononuclear phagocytes. Traditionally, CD68 is exploited as a…”
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Endothelial Barrier and Its Abnormalities in Cardiovascular Disease by Chistiakov, Dimitry A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Endothelial cells (ECs) form a unique barrier between the vascular lumen and the vascular wall. In addition, the endothelium is highly metabolically active. In…”
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Effect of nano‐curcumin on various diseases: A comprehensive review of clinical trials by Hassanizadeh, Shirin, Shojaei, Mehrnaz, Bagherniya, Mohammad, Orekhov, Alexander N., Sahebkar, Amirhossein

“…The antioxidant, anti‐inflammatory, and antibacterial properties of curcumin have made it a valuable herbal product for improving various disorders, such as…”
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MicroRNAs as Potential Biomarkers in Atherosclerosis by Churov, Alexey, Summerhill, Volha, Grechko, Andrey, Orekhova, Varvara, Orekhov, Alexander

“…Atherosclerosis is a complex multifactorial disease that, despite advances in lifestyle management and drug therapy, remains to be the major cause of high…”
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Overview of OxLDL and Its Impact on Cardiovascular Health: Focus on Atherosclerosis by Poznyak, Anastasia V, Nikiforov, Nikita G, Markin, Alexander M, Kashirskikh, Dmitry A, Myasoedova, Veronika A, Gerasimova, Elena V, Orekhov, Alexander N

“…Cardiovascular pathologies maintain the leading position in mortality worldwide. Atherosclerosis is a chronic disease that can result in a variety of serious…”
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The role of miR-126 in embryonic angiogenesis, adult vascular homeostasis, and vascular repair and its alterations in atherosclerotic disease by Chistiakov, Dimitry A, Orekhov, Alexander N, Bobryshev, Yuri V

“…Abstract Expression of microRNA (miR)-126 is enriched in endothelial cells (ECs) and endothelial progenitor cells (EPCs). MiR-126 is considered a master…”
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The role of mitochondria dysfunction and hepatic senescence in NAFLD development and progression by Dabravolski, Siarhei A., Bezsonov, Evgeny E., Orekhov, Alexander N.

“…Senescence is a crucial player in several metabolic disorders and chronic inflammatory diseases. Recent data prove the involvement of hepatocyte senescence in…”
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Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology by Bezsonov, Evgeny E, Sobenin, Igor A, Orekhov, Alexander N

“…In this Special Issue of the , we include insightful reviews and research papers on the subject "Immunopathology of Atherosclerosis and Related Diseases: Focus…”
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Small Dense Low-Density Lipoprotein as Biomarker for Atherosclerotic Diseases by Grechko, Andrey V., Melnichenko, Alexandra A., Myasoedova, Veronika A., Ivanova, Ekaterina A., Orekhov, Alexander N.

“…Low-density lipoprotein (LDL) plays a key role in the development and progression of atherosclerosis and cardiovascular disease. LDL consists of several…”
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Modified low density lipoprotein and lipoprotein-containing circulating immune complexes as diagnostic and prognostic biomarkers of atherosclerosis and type 1 diabetes macrovascular disease by Orekhov, Alexander N, Bobryshev, Yuri V, Sobenin, Igor A, Melnichenko, Alexandra A, Chistiakov, Dimitry A

“…In atherosclerosis; blood low-density lipoproteins (LDL) are subjected to multiple enzymatic and non-enzymatic modifications that increase their atherogenicity…”
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Molecular Aspects of Inflammation and Lipid Metabolism in Health and Disease: The Role of the Mitochondria by Sukhorukov, Vasily N, Orekhov, Alexander N

“…Inflammation and lipid metabolism are two deeply interconnected and reciprocally regulated major physiological processes [...]…”
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The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2 by Chistiakov, Dimitry A., Myasoedova, Veronika A., Revin, Victor V., Orekhov, Alexander N., Bobryshev, Yuri V.

“…Exposure of monocytes to inflammatory or anti-inflammatory conditions also induces predominant differentiation to proinflammatory (M1) or anti-inflammatory…”
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