Search Results - "Orci, Lelio"

Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study by Cosson, Pierre, Marchetti, Anna, Ravazzola, Mariella, Orci, Lelio

“…Besides its role in controlling the morphology of mitochondria, mitofusin-2 has been proposed to tether mitochondria to the endoplasmic reticulum (ER), based…”
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Paracrinology of islets and the paracrinopathy of diabetes by Unger, Roger H., Orci, Lelio

“…New results have brought to light the importance of the regulation of glucagon by β-cells in the development of diabetes. In this perspective, we examine the…”
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STIM1-induced precortical and cortical subdomains of the endoplasmic reticulum by Orci, Lelio, Ravazzola, Mariella, Le Coadic, Marion, Shen, Wei-wei, Demaurex, Nicolas, Cosson, Pierre

“…Store-operated calcium entry relies on the formation of a specialized compartment derived from the endoplasmic reticulum (ER) and closely apposed to the plasma…”
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Coordination of COPII vesicle trafficking by Sec23 by Fromme, J. Christopher, Orci, Lelio, Schekman, Randy

“…Coat protein complex II (COPII) is a multi-subunit protein complex responsible for the formation of membrane vesicles at the endoplasmic reticulum. The…”
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Sar1p N-Terminal Helix Initiates Membrane Curvature and Completes the Fission of a COPII Vesicle by Lee, Marcus C.S., Orci, Lelio, Hamamoto, Susan, Futai, Eugene, Ravazzola, Mariella, Schekman, Randy

“…Secretory proteins traffic from the ER to the Golgi via COPII-coated transport vesicles. The five core COPII proteins (Sar1p, Sec23/24p, and Sec13/31p) act in…”
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Lipoapoptosis: its mechanism and its diseases by Unger, Roger H, Orci, Lelio

“…The balance between cell division and cell death determines the cell population of an organ. When cell death exceeds cell replacement in an organ, a functional…”
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Bi-directional protein transport between the ER and Golgi by Lee, Marcus C S, Miller, Elizabeth A, Goldberg, Jonathan, Orci, Lelio, Schekman, Randy

“…The endoplasmic reticulum (ER) and the Golgi comprise the first two steps in protein secretion. Vesicular carriers mediate a continuous flux of proteins and…”
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Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking by Boyadjiev, Simeon A, Fromme, J Christopher, Ben, Jin, Chong, Samuel S, Nauta, Christopher, Hur, David J, Zhang, George, Hamamoto, Susan, Schekman, Randy, Ravazzola, Mariella, Orci, Lelio, Eyaid, Wafaa

“…Cranio-lenticulo-sutural dysplasia (CLSD) is an autosomal recessive syndrome characterized by late-closing fontanels, sutural cataracts, facial dysmorphisms…”
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Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome by Wang, May-Yun, Grayburn, Paul, Chen, Shuyuan, Ravazzola, Mariella, Orci, Lelio, Unger, Roger H

“…To determine whether adipocyte storage capacity influences the onset and severity of type 2 diabetes and other components of the metabolic syndrome, we made…”
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Diseases of liporegulation: new perspective on obesity and related disorders by UNGER, ROGER H., ORCI, LELIO

“…ABSTRACT Obesity‐related diseases now threaten to reach epidemic proportions in the United States. Here we review in a rodent model of genetic obesity, the…”
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Coat Proteins and Vesicle Budding by Schekman, Randy, Orci, Lelio

“…The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane…”
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Exomer: a coat complex for transport of select membrane proteins from the trans-Golgi network to the plasma membrane in yeast by Wang, Chao-Wen, Hamamoto, Susan, Orci, Lelio, Schekman, Randy

“…Ayeast plasma membrane protein, Chs3p, transits to the mother-bud neck from a reservoir comprising the trans-Golgi network (TGN) and endosomal system. Two…”
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Lipotoxic Heart Disease in Obese Rats: Implications for Human Obesity by Zhou, Yan-Ting, Grayburn, Paul, Karim, Asad, Shimabukuro, Michio, Higa, Moritake, Baetens, Dany, Orci, Lelio, Unger, Roger H.

“…To determine the mechanism of the cardiac dilation and reduced contractility of obese Zucker Diabetic Fatty rats, myocardial triacylglycerol (TG) was assayed…”
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Induction of cortical endoplasmic reticulum by dimerization of a coatomer-binding peptide anchored to endoplasmic reticulum membranes by Lavieu, Grégory, Orci, Lelio, Shi, Lei, Geiling, Michael, Ravazzola, Mariella, Wieland, Felix, Cosson, Pierre, Rothman, James E

“…Cortical endoplasmic reticulum (cER) is a permanent feature of yeast cells but occurs transiently in most animal cell types. Ist2p is a transmembrane protein…”
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SEC23-SEC31 the Interface Plays Critical Role for Export of Procollagen from the Endoplasmic Reticulum by Kim, Sun-Don, Pahuja, Kanika Bajaj, Ravazzola, Mariella, Yoon, Joonsik, Boyadjiev, Simeon A., Hammamoto, Susan, Schekman, Randy, Orci, Lelio, Kim, Jinoh

“…COPII proteins are essential for exporting most cargo molecules from the endoplasmic reticulum. The membrane-facing surface of the COPII proteins (especially…”
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Fat storage in adipocytes requires inactivation of leptin's paracrine activity: Implications for treatment of human obesity by Wang, M.Y, Orci, L, Ravazzola, M, Unger, R.H

“…Hyperleptinemia rapidly depletes adipocyte fat in lean rats, whereas comparable hyperleptinemia produced by adipocytes in diet-induced obesity does not,…”
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Rapid Transformation of White Adipocytes into Fat-Oxidizing Machines by Orci, Lelio, Cook, William S., Ravazzola, Mariella, Wang, May-yun, Park, Byung-Hyun, Montesano, Roberto, Unger, Roger H.

“…Adenovirus-induced hyperleptinemia rapidly depletes body fat in normal rats without increasing free fatty acids and ketogenesis, implying that fat-storing…”
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Transmembrane domains control exclusion of membrane proteins from clathrin-coated pits by Mercanti, Valentina, Marchetti, Anna, Lelong, Emmanuelle, Perez, Franck, Orci, Lelio, Cosson, Pierre

“…Efficient sorting of proteins is essential to allow transport between intracellular compartments while maintaining their specific composition. During…”
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Regulation of fatty acid homeostasis in cells: novel role of leptin by Unger, R.H. (University of Texas, Dallas.), Zhou, Y.T, Orci, L

“…It is proposed that an important function of leptin is to confine the storage of triglycerides (TG) to the adipocytes, while limiting TG storage in…”
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Uncoupled Packaging of Amyloid Precursor Protein and Presenilin 1 into Coat Protein Complex II Vesicles by Kim, Jinoh, Hamamoto, Susan, Ravazzola, Mariella, Orci, Lelio, Schekman, Randy

“…Mutant forms of presenilin (PS) 1 and 2 and amyloid precursor protein (APP) lead to familial Alzheimer's disease. Several reports indicate that PS may modulate…”
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