Search Results - "Orchard, Jenny A"

ZAP-70 expression and prognosis in chronic lymphocytic leukaemia by Orchard, Jenny A, Ibbotson, Rachel E, Davis, Zadie, Wiestner, Adrian, Rosenwald, Andreas, Thomas, Peter W, Hamblin, Terry J, Staudt, Louis M, Oscier, David G

“…Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease; many patients never need treatment, whereas some have poor outcomes. New treatments, which can…”
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ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile by Wiestner, Adrian, Rosenwald, Andreas, Barry, Todd S., Wright, George, Davis, R. Eric, Henrickson, Sarah E., Zhao, Hong, Ibbotson, Rachel E., Orchard, Jenny A., Davis, Zadie, Stetler-Stevenson, Maryalice, Raffeld, Mark, Arthur, Diane C., Marti, Gerald E., Wilson, Wyndham H., Hamblin, Terry J., Oscier, David G., Staudt, Louis M.

“…The presence or absence of somatic mutations in the expressed immunoglobulin heavy chain variable regions (IgVH) of chronic lymphocytic leukemia (CLL) cells…”
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CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease by Hamblin, Terry J., Orchard, Jenny A., Ibbotson, Rachel E., Davis, Zadie, Thomas, Peter W., Stevenson, Freda K., Oscier, David G.

“…Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgVH) genes in chronic lymphocytic leukemia (B-CLL) identifies…”
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Multivariate analysis of prognostic factors in CLL: clinical stage, IGVH gene mutational status, and loss or mutation of the p53 gene are independent prognostic factors by Oscier, David G., Gardiner, Anne C., Mould, Sarah J., Glide, Sharron, Davis, Zadie A., Ibbotson, Rachel E., Corcoran, Martin M., Chapman, Robert M., Thomas, Peter W., Copplestone, J. Adrian, Orchard, Jenny A., Hamblin, Terry J.

“…This study evaluates the prognostic significance of genetic abnormalities (detected at or shortly after presentation), clinical stage, lymphocyte morphology,…”
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Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms by Davis, Zadie A., Orchard, Jenny A., Corcoran, Martin M., Oscier, David G.

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ZAP-70 by Flow Cytometry: Comparison of Methodologies, and with IgVH Mutational and ZAP-70 Methylation Status by Orchard, Jenny A., Best, Oliver G., Ibbotson, Rachel E., Parker, Anton E., Oscier, David G.

“…ZAP-70 is a useful prognostic marker in chronic lymphocytic leukaemia, expression showing concordance with unmutated IgVH genes and poor prognosis. Measuring…”
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How Many Somatic Mutations Should We allow the Subset of Chronic Lymphocytic Leukemia with Unmutated IgVH Genes? by Hamblin, Terry John, Orchard, Jenny A., Davies, Zadie A., Ibbotson, Rachel E., Gardiner, Ann C., Oscier, David G.

“…Although the distinction between chronic lymphocytic leukemia (CLL) with mutated and unmutated immunoglobulin variable region heavy chain (IgVH) genes is well…”
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In Chronic Lymphocytic Leukemia Females Survive for Longer Than Males Even in Patients with Unmutated Immunoglobulin Genes by Hamblin, Terry John, Orchard, Jenny A., Davies, Zadie A., Ibbotson, Rachel E., Gardiner, Ann C., Copplestone, Adrian, Oscier, David G.

“…Among the proposed prognostic factors for chronic lymphocytic leukemia (CLL), gender has been constant. In published trials females survive longer. With the…”
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Unmutated Immunoglobulin Heavy Chain Variable Region Genes and Disease Progression Post Splenectomy Are Poor Prognostic Factors in Splenic Marginal Zone Lymphoma by Oscier, David Graham, Mould, Sarah J., Gardiner, Anne C., Glide, Sharron, Parker, Anton E., Davis, Zadie A., Orchard, Jenny A.

“…Splenic marginal zone lymphoma (SMZL) is generally an indolent disorder which has a median survival of 10 – 13 years, but a minority of patients pursue a more…”
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The Natural History of Mutated, Stage AO Chronic Lymphocytic Leukemia by Oscier, David Graham, Gardiner, Anne C., Mould, Sarah J., Glide, Sharron, Davis, Zadie A., Corcoran, Martin, Wiestner, Adrian, Staudt, Louis M., Thomas, Peter, Orchard, Jenny A.

“…Patients who present with stage AO CLL and have mutated IgVH genes are generally considered to represent a benign sub-set of CLL with prolonged survival…”
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