Search Results - "Orchard, C"

Discovery of a proteinaceous cellular receptor for a norovirus by Orchard, Robert C., Wilen, Craig B., Doench, John G., Baldridge, Megan T., McCune, Broc T., Lee, Ying-Chiang J., Lee, Sanghyun, Pruett-Miller, Shondra M., Nelson, Christopher A., Fremont, Daved H., Virgin, Herbert W.

“…Noroviruses (NoVs) are a leading cause of gastroenteritis globally, yet the host factors required for NoV infection are poorly understood. We identified host…”
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Metabolic reprogramming tips vaccinia virus infection outcomes by stabilizing interferon-γ induced IRF1 by Chang, Tyron, Alvarez, Jessica, Chappidi, Sruthi, Crockett, Stacey, Sorouri, Mahsa, Orchard, Robert C, Hancks, Dustin C

“…Interferon (IFN) induced activities are critical, early determinants of immune responses and infection outcomes. A key facet of IFN responses is the…”
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Identification of Antinorovirus Genes in Human Cells Using Genome-Wide CRISPR Activation Screening by Orchard, Robert C, Sullender, Meagan E, Dunlap, Bria F, Balce, Dale R, Doench, John G, Virgin, Herbert W

“…Noroviruses (NoVs) are a leading cause of gastroenteritis worldwide, yet host factors that restrict NoV replication are not well understood. Here, we use a…”
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Structural basis for murine norovirus engagement of bile acids and the CD300lf receptor by Nelson, Christopher A., Wilen, Craig B., Dai, Ya-Nan, Orchard, Robert C., Kim, Arthur S., Stegeman, Roderick A., Hsieh, Leon L., Smith, Thomas J., Virgin, Herbert W., Fremont, Daved H.

“…Murine norovirus (MNoV) is closely related to human norovirus (HNoV), an infectious agent responsible for acute gastroenteritis worldwide. Here we report the…”
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A systematic exploration of the interactions between bacterial effector proteins and host cell membranes by Weigele, Bethany A., Orchard, Robert C., Jimenez, Alyssa, Cox, Gregory W., Alto, Neal M.

“…Membrane-bound organelles serve as platforms for the assembly of multi-protein complexes that function as hubs of signal transduction in eukaryotic cells…”
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Viral Replication Complexes Are Targeted by LC3-Guided Interferon-Inducible GTPases by Biering, Scott B., Choi, Jayoung, Halstrom, Rachel A., Brown, Hailey M., Beatty, Wandy L., Lee, Sanghyun, McCune, Broc T., Dominici, Erin, Williams, Lelia E., Orchard, Robert C., Wilen, Craig B., Yamamoto, Masahiro, Coers, Jörn, Taylor, Gregory A., Hwang, Seungmin

“…All viruses with positive-sense RNA genomes replicate on membranous structures in the cytoplasm called replication complexes (RCs). RCs provide an advantageous…”
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A Noncanonical Autophagy Pathway Restricts Toxoplasma gondii Growth in a Strain-Specific Manner in IFN-γ-Activated Human Cells by Selleck, Elizabeth M, Orchard, Robert C, Lassen, Kara G, Beatty, Wandy L, Xavier, Ramnik J, Levine, Beth, Virgin, Herbert W, Sibley, L David

“…A core set of autophagy proteins is required for gamma interferon (IFN-γ)-mediated clearance of Toxoplasma gondii in the mouse because of their control of…”
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CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus by Graziano, Vincent R, Walker, Forrest C, Kennedy, Elizabeth A, Wei, Jin, Ettayebi, Khalil, Strine, Madison S, Filler, Renata B, Hassan, Ebrahim, Hsieh, Leon L, Kim, Arthur S, Kolawole, Abimbola O, Wobus, Christiane E, Lindesmith, Lisa C, Baric, Ralph S, Estes, Mary K, Orchard, Robert C, Baldridge, Megan T, Wilen, Craig B

“…Murine norovirus (MNoV) is an important model of human norovirus (HNoV) and mucosal virus infection more broadly. Viral receptor utilization is a major…”
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Self-management intervention to reduce pulmonary exacerbations by supporting treatment adherence in adults with cystic fibrosis: a randomised controlled trial by Wildman, Martin J, O'Cathain, Alicia, Maguire, Chin, Arden, Madelynne A, Hutchings, Marlene, Bradley, Judy, Walters, Stephen J, Whelan, Pauline, Ainsworth, John, Buchan, Iain, Mandefield, Laura, Sutton, Laura, Tappenden, Paul, Elliott, Rachel A, Hoo, Zhe Hui, Drabble, Sarah J, Beever, Daniel

“…Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent…”
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Controlling factors of sheet erosion under degraded grasslands in the sloping lands of KwaZulu-Natal, South Africa by Dlamini, P., Orchard, C., Jewitt, G., Lorentz, S., Titshall, L., Chaplot, V.

“…The current increase in the global demand for food and fresh water and the associated land use changes or misuses exacerbate water erosion which has become a…”
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Mimicking GEFs: a common theme for bacterial pathogens by Orchard, Robert C., Alto, Neal M.

“…Summary Small molecular weight GTPases are master regulators of eukaryotic signalling, making them prime targets for bacterial virulence factors. Here, we…”
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Sphingolipid biosynthesis induces a conformational change in the murine norovirus receptor and facilitates viral infection by Orchard, Robert C., Wilen, Craig B., Virgin, Herbert W.

“…Cellular susceptibility to viral infections is in part determined by the presence of a host cellular receptor. Here we use murine norovirus as a model to…”
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Do t‐tubules play a role in arrhythmogenesis in cardiac ventricular myocytes? by Orchard, C. H., Bryant, S. M., James, A. F.

“…The transverse (t‐) tubules of mammalian ventricular myocytes are invaginations of the surface membrane. The function of many of the key proteins involved in…”
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421 A retrospective review of the phenotypes of older UK adult cystic fibrosis patients homozygous for the F508del mutation by Ewence, A.E, Milne, S, Higton, A, Orchard, C

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246 Musculoskeletal symptoms in a cystic fibrosis population by Narang, R, Higton, A, Orchard, C, Lloyd, M

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Quantification of Calcium Entry at the T-Tubules and Surface Membrane in Rat Ventricular Myocytes by Brette, F., Sallé, L., Orchard, C.H.

“…The action potential of cardiac ventricular myocytes is characterized by its long duration, mainly due to Ca flux through L-type Ca channels. Ca entry also…”
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Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival by Redmann, Veronika, Lamb, Christopher A., Hwang, Seungmin, Orchard, Robert C., Kim, Sungsu, Razi, Minoo, Milam, Ashley, Park, Sunmin, Yokoyama, Christine C., Kambal, Amal, Kreamalmeyer, Darren, Bosch, Marie K., Xiao, Maolei, Green, Karen, Kim, Jungsu, Pruett-Miller, Shondra M., Ornitz, David M., Allen, Paul M., Beatty, Wandy L., Schmidt, Robert E., DiAntonio, Aaron, Tooze, Sharon A., Virgin, Herbert W.

“…CLEC16A is in a locus genetically linked to autoimmune diseases including multiple sclerosis, but the function of this gene in the nervous system is unknown…”
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Genomic and Functional Analyses of Rhodococcus equi Phages ReqiPepy6, ReqiPoco6, ReqiPine5, and ReqiDocB7 by Summer, E.J, Liu, M, Gill, J.J, Grant, M, Chan-Cortes, T.N, Ferguson, L, Janes, C, Lange, K, Bertoli, M, Moore, C, Orchard, R.C, Cohen, N.D, Young, R

“…The isolation and results of genomic and functional analyses of Rhodococcus equi phages ReqiPepy6, ReqiDocB7, ReqiPine5, and ReqiPoco6 (hereafter referred to…”
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302 A retrospective review of renal function and intravenous (IV) antibiotic use in an adult UK cystic fibrosis centre by Ewence, A.E, Malone, S, Nutbourne, A, Higton, A, Orchard, C

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Identification of F-actin as the Dynamic Hub in a Microbial-Induced GTPase Polarity Circuit by Orchard, Robert C., Kittisopikul, Mark, Altschuler, Steven J., Wu, Lani F., Süel, Gürol M., Alto, Neal M.

“…Polarity in mammalian cells emerges from the assembly of signaling molecules into extensive biochemical interaction networks. Despite their complexity,…”
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