In vitro degradation of porous poly( dl-lactide- co-glycolide) (PLGA)/bioactive glass composite foams with a polar structure

In vitro degradation of porous poly( dl-lactide- co-glycolide) (PLGA)/bioactive glass composite foams with a polar structure

In vitro degradation of porous 50/50, 70/30 and 90/10 PLGA (poly( dl-lactide- co-glycolide)) foams and PLGA/bioactive glass (20 wt%) composite foams was studied up to 16 weeks in TRIS (pH 7.4; 37 °C). Polar PLGA/bioactive glass composite films were prepared by applying the bioactive glass (S53P4) on...

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Bibliographic Details
Published in:Polymer degradation and stability Vol. 92; no. 1; pp. 14 - 23
Main Authors: Orava, Eeva, Korventausta, Joni, Rosenberg, Meri, Jokinen, Mika, Rosling, Ari
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 2007
Elsevier Science
Subjects:
Applied sciences
Bioactive glass
Biological and medical sciences
Cellular
Composite
Composites
Degradable polymers
Exact sciences and technology
Forms of application and semi-finished materials
Medical sciences
Polymer industry, paints, wood
Porosity
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Weight loss
Bioactive glass
Porosity
Composite
Degradable polymers
Weight loss
Biodegradation
Glycolic acid copolymer
Biological properties
Lactone copolymer
Biodegradability
Lactic acid copolymer
Glass
Bioactive material
Experimental study
In vitro
Porous material
Composite material
Pore size
Morphology
Foam(plastics)
Structure modification
Biomaterial
Kinetics
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Summary:In vitro degradation of porous 50/50, 70/30 and 90/10 PLGA (poly( dl-lactide- co-glycolide)) foams and PLGA/bioactive glass (20 wt%) composite foams was studied up to 16 weeks in TRIS (pH 7.4; 37 °C). Polar PLGA/bioactive glass composite films were prepared by applying the bioactive glass (S53P4) on one side of the composite. Porous foams were made by solvent casting and pressure quenching with CO 2. The fabricated foams had an initial pore size of 50–500 μm and thickness of 2–2.5 mm. In vitro degradation of the prepared foams was evaluated after 1, 2, 4, 6, 8, 12 and 16 weeks. Weight loss, water uptake, molecular mass and the amount of dissolved bioactive glass were measured after each time period. Changes in pore morphology were analysed with SEM. The present in vitro results will be evaluated and compared with the results from ongoing animal studies where comparable implants are used for bone defect treatment under non-load-bearing conditions.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0141-3910
1873-2321
DOI:10.1016/j.polymdegradstab.2006.10.004