Search Results - "Or, Penelope M.Y."

Major tanshinones of Danshen ( Salvia miltiorrhiza) exhibit different modes of inhibition on human CYP1A2, CYP2C9, CYP2E1 and CYP3A4 activities in vitro by Wang, Xin, Cheung, Ching Mei, Lee, Wayne Y.W., Or, Penelope M.Y., Yeung, John H.K.

“…This study investigated the effects of tanshinones on human CYP1A2 (phenacetin O-deethylase), CYP2C9 (tolbutamide 4-hydroxylase), CYP2E1 (chlorzoxazone…”
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Danshensu is the major marker for the antioxidant and vasorelaxation effects of Danshen (Salvia miltiorrhiza) water-extracts produced by different heat water-extractions by Zhou, Xuelin, Chan, Shun Wan, Tseng, Hui Ling, Deng, Yan, Hoi, Pui Man, Choi, Pou Seng, Or, Penelope M.Y., Yang, Jia-ming, Lam, Francis F.Y., Lee, Simon Ming Yuen, Leung, George Pak Heng, Kong, Siu Kai, Ho, Ho Pui, Kwan, Yiu Wa, Yeung, John H.K.

“…Some of the major components of Danshen (Salvia miltiorrhiza), a widely used Chinese herbal medicine rich in phenolic acids, are thermosensitive and may…”
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Effects of Radix Astragali and Radix Rehmanniae, the components of an anti-diabetic foot ulcer herbal formula, on metabolism of model CYP1A2, CYP2C9, CYP2D6, CYP2E1 and CYP3A4 probe substrates in pooled human liver microsomes and specific CYP isoforms by Or, Penelope M.Y., Lam, Francis F.Y., Kwan, Y.W., Cho, C.H., Lau, C.P., Yu, H., Lin, G., Lau, Clara B.S., Fung, K.P., Leung, P.C., Yeung, John H.K.

“…The present study investigated the effects of Radix Astragali (RA) and Radix Rehmanniae (RR), the major components of an anti-diabetic foot ulcer herbal…”
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Molecular docking and enzyme kinetic studies of dihydrotanshinone on metabolism of a model CYP2D6 probe substrate in human liver microsomes by Zhou, Xuelin, Wang, Yan, Or, Penelope M.Y., Wan, David C.C., Kwan, Yiu Wa, Yeung, John H.K.

“…The effects of Danshen and its active components (tanshinone I, tanshinone IIA, dihydrotanshinone and cryptotanshinone) on CYP2D6 activity was investigated by…”
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Differential sensitivities of glioblastoma cell lines towards metabolic and signaling pathway inhibitions by Kennedy, Colin R, Tilkens, Sarah B, Guan, Hong, Garner, Justine A, Or, Penelope M.Y, Chan, Andrew M

“…Highlights • The proliferation of GBM cell lines displayed different sensitivities towards oligomycin or 2DG. • Differential sensitivities of GBM cell lines…”
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Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes by Yeung, John H.K., Or, Penelope M.Y.

“…Polysaccharide peptide (PSP), isolated from COV-1 strain of Coriolus versicolor, is commonly used as an adjunct in cancer chemotherapy or health supplement in…”
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Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes by Zhou, Xuelin, Wang, Yan, Hu, Tao, Or, Penelope M.Y., Wong, John, Kwan, Yiu Wa, Wan, David C.C., Hoi, Pui Man, Lai, Paul B.S., Yeung, John H.K.

“…Previous studies have shown that major tanshinones isolated from Danshen (Salvia miltiorrhiza) inhibited human and rat CYP450 enzymes-mediated metabolism of…”
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Dihydrotanshinone, a lipophilic component of Salvia miltiorrhiza (danshen), relaxes rat coronary artery by inhibition of calcium channels by Lam, Francis F.Y., Yeung, John H.K., Chan, Kam M., Or, Penelope M.Y.

“…Dihydrotanshinone is a lipophilic component of the medicinal herb Salvia miltiorrhiza (danshen) belonging to the family of Labiatae. In this study, we have…”
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Mechanisms of the dilator action of cryptotanshinone on rat coronary artery by Lam, Francis F.Y., Yeung, John H.K., Chan, Kam M., Or, Penelope M.Y.

“…In this study, we have investigated the actions of cryptotanshinone, an active, lipophilic component of the medicinal herb danshen ( Salvia miltiorrhiza), on…”
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Enzyme kinetic and molecular docking studies on the metabolic interactions of 1-hydroxy-2,3,5-trimethoxy-xanthone, isolated from Halenia elliptica D. Don, with model probe substrates of human cytochrome P450 enzymes by Feng, Ru, Zhou, Xuelin, Or, Penelope M.Y., Ma, Jing-Yi, Tan, Xiang-Shan, Fu, Jie, Ma, Chao, Shi, Jian-Gong, Che, Chun-Tao, Wang, Yan, Yeung, John H.K.

“…Halenia elliptica D. Don is a Tibetan herb and medicinal preparations containing Halenia elliptica have been commonly used for the treatment of hepatitis B…”
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A pharmacodynamic–pharmacokinetic (PD–PK) study on the effects of Danshen ( Salvia miltiorrhiza) on midazolam, a model CYP3A probe substrate, in the rat by Wang, Xin, Lee, Wayne Y.W., Zhou, Xuelin, Or, Penelope M.Y., Yeung, John H.K.

“…This study investigated the effect of Danshen on the pharmacodynamic–pharmacokinetic (PD–PK) effects of midazolam, a model CYP3A probe substrate. The effects…”
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Effects of major tanshinones isolated from Danshen ( Salvia miltiorrhiza) on rat CYP1A2 expression and metabolism of model CYP1A2 probe substrates by Wang, Xin, Lee, Wayne Y.W., Or, Penelope M.Y., Yeung, John H.K.

“…This study explored the effects of Danshen on metabolism/pharmacokinetics of model CYP1A2 substrates and hepatic CYP1A2 expression in rats. The effects of…”
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Effects of polysaccharide peptides from COV-1 strain of Coriolus versicolor on glutathione and glutathione-related enzymes in the mouse by Yeung, John H.K., Or, Penelope M.Y.

“…The effects of polysaccharide peptide (PSP), an immunomodulator isolated from Coriolus versicolor COV-1, on glutathione (GSH) and GSH-related enzymes was…”
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Abstract 3062: Unraveling the role of RCC2 in glioblastoma by mutational analysis and a murine model of glioma by Ho, Wayne L.H., Or, Penelope M.Y., Chan, Andrew M.

“…Abstract Glioblastoma (GBM) is a brain malignancy characterized by being highly aggressive, lethal, yet treatment modalities remain limited. Recent studies…”
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Astrocyte-specific knockout of YKL-40/Chi3l1 reduces Aβ burden and restores memory functions in 5xFAD mice by Zeng, Xiaoyan, Cheung, Stanley K. K., Shi, Mengqi, Or, Penelope M. Y., Li, Zhining, Liu, Julia Y. H., Ho, Wayne L. H., Liu, Tian, Lu, Kun, Rudd, John A., Wang, Yubing, Chan, Andrew M.

“…Abstract Glial cell-mediated neuroinflammation and neuronal attrition are highly correlated with cognitive impairment in Alzheimer’s disease. YKL-40 is a…”
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Neuropathological signatures revealed by transcriptomic and proteomic analysis in Pten-deficient mouse models by Cheung, Stanley K. K., Kwok, Jacinda, Or, Penelope M. Y., Wong, Chi Wai, Feng, Bo, Choy, Kwong Wai, Chang, Raymond C. C., Burbach, J. Peter H., Cheng, Alfred S. L., Chan, Andrew M.

“…PTEN hamartoma tumour syndrome is characterised by mutations in the human PTEN gene. We performed transcriptomic and proteomic analyses of neural tissues and…”
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Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: Enzyme kinetic and molecular docking studies by Hu, Tao, Zhou, Xuelin, Wang, Lin, Or, Penelope M.Y., Yeung, John H.K., Kwan, Yiu Wa, Cho, Chi Hin

“…•The inhibition of five tanshinones on CYP2C19 in human liver microsomes was compared.•Drug binding in the catalytic site of CYP2C19 was simulated in…”
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Danshen (Salvia miltiorrhiza) water extract inhibits paracetamol-induced toxicity in primary rat hepatocytes via reducing CYP2E1 activity and oxidative stress by Zhou, Xuelin, Cheung, Ching Mei, Yang, Jia-ming, Or, Penelope M.Y., Lee, Wayne Y.W., Yeung, John H.K.

“…Objectives This study aimed to investigate the protective effects of Danshen (Salvia miltiorrhiza) water extract (DSE) and its major phenolic acid components…”
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Tumour‐derived substrate‐adherent cells promote neuroblastoma survival through secreted trophic factors by Li, Jing, Wang, Yubing, Li, Lisha, Or, Penelope M.‐Y., Wai Wong, Chi, Liu, Tian, Ho, Wayne L.H., Chan, Andrew M.

“…Neuroblastoma (NB) is the most common extracranial solid tumour in children. NB is highly heterogeneous and is comprised of a mixture of neuroblastic cancer…”
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Herb–drug interaction between an anti-HIV Chinese herbal SH formula and atazanavir in vitro and in vivo by Cheng, Bao-Hui, Zhou, Xuelin, Wang, Yan, Chan, Judy Yuet-Wa, Lin, Huang-Quan, Or, Penelope M.Y., Wan, David Chi-Cheong, Leung, Ping-Chung, Fung, Kwok-Pui, Wang, Yi-Fen, Lau, Clara Bik-San

“…With the prevalent use of highly active antiretroviral therapy (HAART) for AIDS patients since 1996, the mortality of HIV/AIDS patients has been remarkably…”
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