Search Results - "Opravil, Susanne"

Repression of p53 activity by Smyd2-mediated methylation by Perez-Burgos, Laura, Sengupta, Roopsha, Jenuwein, Thomas, Huang, Jing, Richter, Mario, Dorsey, Jean A, Kubicek, Stefan, Berger, Shelley L, Opravil, Susanne, Placek, Brandon J

“…Specific sites of lysine methylation on histones correlate with either activation or repression of transcription. The tumour suppressor p53 (refs 4-7) is one…”
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A transcription factor–based mechanism for mouse heterochromatin formation by Bulut-Karslioglu, Aydan, Perrera, Valentina, Scaranaro, Manuela, de la Rosa-Velazquez, Inti Alberto, van de Nobelen, Suzanne, Shukeir, Nicholas, Popow, Johannes, Gerle, Borbala, Opravil, Susanne, Pagani, Michaela, Meidhof, Simone, Brabletz, Thomas, Manke, Thomas, Lachner, Monika, Jenuwein, Thomas

“…The mechanisms that initiate heterochromatin formation and maintain its distinction from euchromatin have remained elusive. However, a new study reveals a…”
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A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse by Schotta, Gunnar, Sengupta, Roopsha, Kubicek, Stefan, Malin, Stephen, Kauer, Monika, Callén, Elsa, Celeste, Arkady, Pagani, Michaela, Opravil, Susanne, De La Rosa-Velazquez, Inti A, Espejo, Alexsandra, Bedford, Mark T, Nussenzweig, André, Busslinger, Meinrad, Jenuwein, Thomas

“…H4K20 methylation is a broad chromatin modification that has been linked with diverse epigenetic functions. Several enzymes target H4K20 methylation,…”
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The profile of repeat-associated histone lysine methylation states in the mouse epigenome by Martens, Joost HA, O'Sullivan, Roderick J, Braunschweig, Ulrich, Opravil, Susanne, Radolf, Martin, Steinlein, Peter, Jenuwein, Thomas

“…Histone lysine methylation has been shown to index silenced chromatin regions at, for example, pericentric heterochromatin or of the inactive X chromosome…”
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Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells by Fodor, Barna D, Kubicek, Stefan, Yonezawa, Masato, O'Sullivan, Roderick J, Sengupta, Roopsha, Perez-Burgos, Laura, Opravil, Susanne, Mechtler, Karl, Schotta, Gunnar, Jenuwein, Thomas

“…Histone lysine trimethyl states represent some of the most robust epigenetic modifications in eukaryotic chromatin. Using a candidate approach, we identified…”
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AAA-ATPase molecular chaperone Cdc48/p97 disassembles sumoylated centromeres, decondenses heterochromatin, and activates ribosomal RNA genes by Mérai, Zsuzsanna, Chumak, Nina, García-Aguilar, Marcelina, Hsieh, Tzung-Fu, Nishimura, Toshiro, Schoft, Vera K., Bindics, János, Ślusarz, Lucyna, Arnoux, Stéphanie, Opravil, Susanne, Mechtler, Karl, Zilberman, Daniel, Fischer, Robert L., Tamaru, Hisashi

“…Centromeres mediate chromosome segregation and are defined by the centromere-specific histone H3 variant (CenH3)/centromere protein A (CENP-A). Removal of…”
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Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin by Peters, Antoine H.F.M., Kubicek, Stefan, Mechtler, Karl, O'Sullivan, Roderick J., Derijck, Alwin A.H.A., Perez-Burgos, Laura, Kohlmaier, Alexander, Opravil, Susanne, Tachibana, Makoto, Shinkai, Yoichi, Martens, Joost H.A., Jenuwein, Thomas

“…Methylation of position-specific lysine residues in histone N termini is a central modification for regulating epigenetic transitions in chromatin. Each…”
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Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability by Peters, Antoine H.F.M., O'Carroll, Dónal, Scherthan, Harry, Mechtler, Karl, Sauer, Stephan, Schöfer, Christian, Weipoltshammer, Klara, Pagani, Michaela, Lachner, Monika, Kohlmaier, Alexander, Opravil, Susanne, Doyle, Michael, Sibilia, Maria, Jenuwein, Thomas

“…Histone H3 lysine 9 methylation has been proposed to provide a major “switch” for the functional organization of chromosomal subdomains. Here, we show that the…”
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Regulation of chromatin structure by site-specific histone H3 methyltransferases by Sun, Zu-Wen, Ponting, Chris P, O'Carroll, Dónal, Opravil, Susanne, Jenuwein, Thomas, Schmid, Manfred, Allis, C. David, Mechtler, Karl, Rea, Stephen, Strahl, Brian D, Eisenhaber, Frank

“…The organization of chromatin into higher-order structures influences chromosome function and epigenetic gene regulation. Higher-order chromatin has been…”
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p53 is regulated by the lysine demethylase LSD1 by Jenuwein, Thomas, Shiekhattar, Ramin, Dorsey, Jean A, Espejo, Alexsandra B, Lee, Min Gyu, Richter, Mario, Berger, Shelley L, Bedford, Mark T, Opravil, Susanne, Huang, Jing, Sengupta, Roopsha

“…p53, the tumour suppressor and transcriptional activator, is regulated by numerous post-translational modifications, including lysine methylation. Histone…”
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SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation by Kaufmann, Tanja, Kukolj, Eva, Brachner, Andreas, Beltzung, Etienne, Bruno, Melania, Kostrhon, Sebastian, Opravil, Susanne, Hudecz, Otto, Mechtler, Karl, Warren, Graham, Slade, Dea

“…Sirtuin 2 (SIRT2) is an NAD-dependent deacetylase known to regulate microtubule dynamics and cell cycle progression. SIRT2 has also been implicated in the…”
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Spatiotemporal Regulation of Ipl1/Aurora Activity by Direct Cdk1 Phosphorylation by Zimniak, Tomasz, Fitz, Veronika, Zhou, Hongwen, Lampert, Fabienne, Opravil, Susanne, Mechtler, Karl, Stolt-Bergner, Peggy, Westermann, Stefan

“…Oscillating cyclin-dependent kinase 1 (Cdk1) activity is the major regulator of cell-cycle progression [1], whereas the Aurora B kinase, as part of the…”
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Over-expression of the SUV39H1 histone methyltransferase induces altered proliferation and differentiation in transgenic mice by Czvitkovich, Stefan, Sauer, Stephan, Peters, Antoine H.F.M, Deiner, Evi, Wolf, Andrea, Laible, Götz, Opravil, Susanne, Beug, Hartmut, Jenuwein, Thomas

“…The development of multi-cellular organisms is regulated by the ordered definition of gene expression programmes that govern cell proliferation and…”
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A transcription factor-based mechanism for mouse heterochromatin formation by Bulut-karslioglu, Aydan, Perrera, Valentina, Scaranaro, Manuela, De La Rosa-velazquez, Inti Alberto, Van De Nobelen, Suzanne, Shukeir, Nicholas, Popow, Johannes, Gerle, Borbala, Opravil, Susanne, Pagani, Michaela, Meidhof, Simone, Brabletz, Thomas, Manke, Thomas, Lachner, Monika, Jenuwein, Thomas

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Erratum: A transcription factor–based mechanism for mouse heterochromatin formation by Bulut-Karslioglu, Aydan, Perrera, Valentina, Scaranaro, Manuela, de la Rosa-Velazquez, Inti Alberto, van de Nobelen, Suzanne, Shukeir, Nicholas, Popow, Johannes, Gerle, Borbala, Opravil, Susanne, Pagani, Michaela, Meidhof, Simone, Brabletz, Thomas, Manke, Thomas, Lachner, Monika, Jenuwein, Thomas

“…Nat. Struct. Mol. Biol. 19, 1023–1030 (2012); published online 16 September 2012; corrected after print 27 December 2012 In the version of this article…”
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Isolation and Characterization of Suv39h2, a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression by O'Carroll, Dónal, Scherthan, Harry, Peters, Antoine H. F. M., Opravil, Susanne, Haynes, Andrew R., Laible, Götz, Rea, Stephen, Schmid, Manfred, Lebersorger, Angelika, Jerratsch, Martin, Sattler, Lydia, Mattei, Marie G., Denny, Paul, Brown, Stephen D. M., Schweizer, Dieter, Jenuwein, Thomas

“…Higher-order chromatin has been implicated in epigenetic gene control and in the functional organization of chromosomes. We have recently discovered mouse…”
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Generation and characterization of methyl-lysine histone antibodies by Perez-Burgos, Laura, Peters, Antoine H F M, Opravil, Susanne, Kauer, Monika, Mechtler, Karl, Jenuwein, Thomas

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p53 is regulated by the lysine demethylase LSD1 by JING HUANG, SENGUPTA, Roopsha, BERGER, Shelley L, ESPEJO, Alexsandra B, MIN GYU LEE, DORSEY, Jean A, RICHTER, Mario, OPRAVIL, Susanne, SHIEKHATTAR, Ramin, BEDFORD, Mark T, JENUWEIN, Thomas

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Isolation and Characterization ofSuv39h2, a Second Histone H3 Methyltransferase Gene That Displays Testis-Specific Expression by Dónal O'Carroll, Harry Scherthan, Antoine H. F. M. Peters, Susanne Opravil, Andrew R. Haynes, Götz Laible, Stephen Rea, Manfred Schmid, Angelika Lebersorger, Martin Jerratsch, Lydia Sattler, Marie G. Mattei, Paul Denny, Stephen D. M. Brown, Dieter Schweizer, Thomas Jenuwein

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