Search Results - "Oppenheim, J. J."

Alarmins and immunity by Yang, De, Han, Zhen, Oppenheim, Joost J.

“…Summary More than a decade has passed since the conceptualization of the “alarmin” hypothesis. The alarmin family has been expanding in terms of both number…”
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Alarmins: chemotactic activators of immune responses by Oppenheim, Joost J, Yang, De

“…The recruitment and activation of antigen-presenting cells are critical early steps in mounting an immune response. Many microbial components and endogenous…”
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Targeting TNFR2, an immune checkpoint stimulator and oncoprotein, is a promising treatment for cancer by Chen, Xin, Oppenheim, Joost J

“…Tumor necrosis factor receptor 2 (TNFR2) is expressed both by some cancer cells and by tumor-infiltrating immunosuppressive CD4 FoxP3 regulatory T cells (T )…”
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Th17 cells and Tregs: unlikely allies by Chen, Xin, Oppenheim, Joost J.

“…Review on the reciprocal stimulatory effects of proinflammatory Th17 cells, wth immunosuppressive Treg cells. Identification of CD4+Foxp3+ Tregs and Th17…”
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High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin by Yang, De, Chen, Qian, Yang, Huan, Tracey, Kevin J., Bustin, Michael, Oppenheim, Joost J.

“…High mobility group box‐1 (HMGB1) protein is a nonhistone, DNA‐binding protein that plays a critical role in regulating gene transcription. Recently, HMGB1 has…”
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Roles of antimicrobial peptides such as defensins in innate and adaptive immunity by Oppenheim, J J, Biragyn, A, Kwak, L W, Yang, D

“…A number of antimicrobial peptides such as defensins have multiple functions in host defence. Defensins are produced not only by phagocytic cells and…”
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Chemokine-like receptor 1 (CMKLR1) and chemokine (C–C motif) receptor-like 2 (CCRL2); Two multifunctional receptors with unusual properties by Yoshimura, Teizo, Oppenheim, Joost J.

“…Chemokine-like receptor 1 (CMKLR1), also known as ChemR23, and chemokine (C–C motif) receptor-like 2 (CCRL2) are 7-transmembrane receptors that were cloned in…”
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Alpha synuclein, the culprit in Parkinson disease, is required for normal immune function by Alam, Md Masud, Yang, De, Li, Xiao-Qing, Liu, Jia, Back, Timothy Carrel, Trivett, Anna, Karim, Baktiar, Barbut, Denise, Zasloff, Michael, Oppenheim, Joost J.

“…Alpha-synuclein (αS) is causally involved in the development of Parkinson disease (PD); however, its role in normal vertebrate physiology has remained unknown…”
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Room-Temperature Quantitative Quantum Sensing of Lithium Ions with a Radical-Embedded Metal–Organic Framework by Sun, Lei, Yang, Luming, Dou, Jin-Hu, Li, Jian, Skorupskii, Grigorii, Mardini, Michael, Tan, Kong Ooi, Chen, Tianyang, Sun, Chenyue, Oppenheim, Julius J., Griffin, Robert G., Dincă, Mircea, Rajh, Tijana

“…Recent advancements in quantum sensing have sparked transformative detection technologies with high sensitivity, precision, and spatial resolution. Owing to…”
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Alarmins link neutrophils and dendritic cells by Yang, De, de la Rosa, Gonzalo, Tewary, Poonam, Oppenheim, Joost J

“…Neutrophils are the first major population of leukocyte to infiltrate infected or injured tissues and are crucial for initiating host innate defense and…”
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Ultrafast Water H‑Bond Rearrangement in a Metal–Organic Framework Probed by Femtosecond Time-Resolved Infrared Spectroscopy by Valentine, Mason L., Yin, Guoxin, Oppenheim, Julius J., Dincǎ, Mircea, Xiong, Wei

“…We investigated the water H-bond network and its dynamics in Ni2Cl2BTDD, a prototypical MOF for atmospheric water harvesting, using linear and ultrafast IR…”
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Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense by Yang, De, Biragyn, Arya, Hoover, David M, Lubkowski, Jacek, Oppenheim, Joost J

“…Mammals generate a diverse array of antimicrobial proteins, largely represented by defensins or cathelicidins. The direct in vitro microbicidal activity of…”
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A Role for Neuronal Alpha-Synuclein in Gastrointestinal Immunity by Stolzenberg, Ethan, Berry, Deborah, Yang, De, Lee, Ernest Y., Kroemer, Alexander, Kaufman, Stuart, Wong, Gerard C.L., Oppenheim, Joost J., Sen, Supti, Fishbein, Thomas, Bax, Ad, Harris, Brent, Barbut, Denise, Zasloff, Michael A.

“…Background: Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and…”
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Monocyte chemoattractant protein-1/CCL2 produced by stromal cells promotes lung metastasis of 4T1 murine breast cancer cells by Yoshimura, Teizo, Howard, O M Zack, Ito, Toshihiro, Kuwabara, Masaki, Matsukawa, Akihiro, Chen, Keqiang, Liu, Ying, Liu, Mingyong, Oppenheim, Joost J, Wang, Ji Ming

“…MCP-1/CCL2 plays an important role in the initiation and progression of cancer. Since tumor cells produce MCP-1, they are considered to be the main source of…”
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Cryptotanshinone has curative dual anti-proliferative and immunotherapeutic effects on mouse Lewis lung carcinoma by Liu, Shuo, Han, Zhen, Trivett, Anna L., Lin, Hongsheng, Hannifin, Sean, Yang, De, Oppenheim, Joost J.

“…Lung cancer is currently the leading cause of cancer-related mortality with very limited effective therapy. Screening of a variety of traditional Chinese…”
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Chemerin reveals its chimeric nature by Yoshimura, Teizo, Oppenheim, Joost J

“…Chemerin is a proinflammatory plasma protein that binds to the GPCR ChemR23/CMKLR1 on macrophages and plasmacytoid dendritic cells, and promotes chemotaxis. An…”
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Blockade of TNFR2 signaling enhances the immunotherapeutic effect of CpG ODN in a mouse model of colon cancer by Nie, Yingjie, He, Jiang, Shirota, Hidekazu, Trivett, Anna L, Yang, De, Klinman, Dennis M, Oppenheim, Joost J, Chen, Xin

“…Through the tumor necrosis factor (TNF) receptor type II (TNFR2), TNF preferentially activates, expands, and promotes the phenotypic stability of CD4 Foxp3…”
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Engineering Disulfide Bridges to Dissect Antimicrobial and Chemotactic Activities of Human β-Defensin 3 by Wu, Zhibin, Hoover, David M., Yang, De, Boulègue, Cyril, Santamaria, Fanny, Oppenheim, Joost J., Lubkowski, Jacek, Lu, Wuyuan

“…Human defensins form a family of small, cationic, and Cys-rich antimicrobial proteins that play important roles in innate immunity against invading microbes…”
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High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin by Yang, De, Han, Zhen, Alam, Md Masud, Oppenheim, Joost J.

“…[Display omitted] •HMGN1, a member of the HMGN family proteins, binds nucleosomes to regulate chromatin structure, histone modification, and gene…”
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Many chemokines including CCL20/MIP-3α display antimicrobial activity by Yang, De, Chen, Qian, Hoover, David M., Staley, Patricia, Tucker, Kenneth D., Lubkowski, Jacek, Oppenheim, Joost J.

“…Previous studies have demonstrated that β‐defensins exhibit chemotactic activity by sharing the chemokine receptor CCR6 with the CC chemokine ligand…”
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