Search Results - "Oppenheim, Frank G."

Identification of Rothia bacteria as gluten-degrading natural colonizers of the upper gastro-intestinal tract by Zamakhchari, Maram, Wei, Guoxian, Dewhirst, Floyd, Lee, Jaeseop, Schuppan, Detlef, Oppenheim, Frank G, Helmerhorst, Eva J

“…Gluten proteins, prominent constituents of barley, wheat and rye, cause celiac disease in genetically predisposed subjects. Gluten is notoriously difficult to…”
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Conformational Changes in Salivary Proline-Rich Protein 1 upon Adsorption to Calcium Phosphate Crystals by Elangovan, Satheesh, Margolis, Henry C, Oppenheim, Frank G, Beniash, Elia

“…Conformational analyses of PRP1, a proline-rich acidic salivary protein and major component of the acquired enamel pellicle, have been carried out in solution…”
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Commensal Bacterium Rothia aeria Degrades and Detoxifies Gluten via a Highly Effective Subtilisin Enzyme by Wei, Guoxian, Darwish, Ghassan, Oppenheim, Frank G, Schuppan, Detlef, Helmerhorst, Eva J

“…Celiac disease is characterized by a chronic immune-mediated inflammation of the small intestine, triggered by gluten contained in wheat, barley, and rye. , a…”
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Salivary Proteome and Its Genetic Polymorphisms by OPPENHEIM, FRANK G., SALIH, ERDJAN, SIQUEIRA, WALTER L., ZHANG, WEIMIN, HELMERHORST, EVA J.

“…:  Salivary diagnostics for oral as well as systemic diseases is dependent on the identification of biomolecules reflecting a characteristic change in…”
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Uncovering the molecular networks in periodontitis by Trindade, Fábio, Oppenheim, Frank G., Helmerhorst, Eva J., Amado, Francisco, Gomes, Pedro S., Vitorino, Rui

“…Periodontitis is a complex immune‐inflammatory disease that results from a preestablished infection in gingiva, mainly due to Gram‐negative bacteria that…”
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Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity by Helmerhorst, Eva J, Zamakhchari, Maram, Schuppan, Detlef, Oppenheim, Frank G

“…Celiac disease is a T cell mediated-inflammatory enteropathy caused by the ingestion of gluten in genetically predisposed individuals carrying HLA-DQ2 or…”
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Identification of Protein Components in in vivo Human Acquired Enamel Pellicle Using LC−ESI−MS/MS by Siqueira, Walter L, Zhang, Weimin, Helmerhorst, Eva J, Gygi, Steven P, Oppenheim, Frank G

“…The acquired enamel pellicle is a thin protein film forming upon exposure of tooth enamel surfaces to saliva. The structural analysis of this integument relies…”
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An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples by Nie, Shuai, Henley, W Hampton, Miller, Scott E, Zhang, Huaibin, Mayer, Kathryn M, Dennis, Patty J, Oblath, Emily A, Alarie, Jean Pierre, Wu, Yue, Oppenheim, Frank G, Little, Frédéric F, Uluer, Ahmet Z, Wang, Peidong, Ramsey, J Michael, Walt, David R

“…During the last decade, saliva has emerged as a potentially ideal diagnostic biofluid for noninvasive testing. In this paper, we present an automated,…”
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Identification of Lys-Pro-Gln as a Novel Cleavage Site Specificity of Saliva-associated Proteases by Helmerhorst, Eva J., Sun, Xiuli, Salih, Erdjan, Oppenheim, Frank G.

“…The nonsterile environment of the oral cavity facilitates substantial proteolytic processing, not only of resident salivary proteins but also of dietary…”
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Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma by Little, Frédéric F, Delgado, Diana M, Wexler, Philip J, Oppenheim, Frank G, Mitchell, Patricia, Feldman, James A, Walt, David R, Peng, Roger D, Matsui, Elizabeth C

“…There is a need for a readily available, non-invasive source of biomarkers that predict poor asthma control. We sought to determine if there is an association…”
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Fiber-Optic Microsphere-Based Antibody Array for the Analysis of Inflammatory Cytokines in Saliva by Blicharz, Timothy M, Siqueira, Walter L, Helmerhorst, Eva J, Oppenheim, Frank G, Wexler, Philip J, Little, Frédéric F, Walt, David R

“…Antibody microarrays have emerged as useful tools for high-throughput protein analysis and candidate biomarker screening. We describe here the development of a…”
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Correlations of salivary biomarkers with clinical assessments in patients with cystic fibrosis by Nie, Shuai, Zhang, Huaibin, Mayer, Kathryn M, Oppenheim, Frank G, Little, Frédéric F, Greenberg, Jonathan, Uluer, Ahmet Z, Walt, David R

“…Monitoring clinical disease status in cystic fibrosis frequently requires invasive collection of clinical samples. Due to its noninvasive collection process…”
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Identification of Protein Components in Human Acquired Enamel Pellicle and Whole Saliva Using Novel Proteomics Approaches by Yao, Yuan, Berg, Eric A, Costello, Catherine E, Troxler, Robert F, Oppenheim, Frank G

“…Precursor proteins of the acquired enamel pellicle derive from glandular and non-glandular secretions, which are components of whole saliva. The purpose of…”
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Mass Spectrometric Identification of Key Proteolytic Cleavage Sites in Statherin Affecting Mineral Homeostasis and Bacterial Binding Domains by Helmerhorst, Eva J, Traboulsi, Georges, Salih, Erdjan, Oppenheim, Frank G

“…Human salivary statherin inhibits both primary and secondary calcium phosphate precipitation and, upon binding to hydroxyapatite, associates with a variety of…”
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Concentration and fate of histatins and acidic proline-rich proteins in the oral environment by Campese, Melanie, Sun, Xiuli, Bosch, Jos A, Oppenheim, Frank G, Helmerhorst, Eva J

“…Abstract Saliva plays a critical role in the protection of oral hard and soft tissues and contains a multitude of constituents with well-characterized…”
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Anti-candidal activity of genetically engineered histatin variants with multiple functional domains by Oppenheim, Frank G, Helmerhorst, Eva J, Lendenmann, Urs, Offner, Gwynneth D

“…The human bodily defense system includes a wide variety of innate antimicrobial proteins. Histatins are small molecular weight proteins produced by the human…”
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The Human Salivary Peptide Histatin 5 Exerts Its Antifungal Activity through the Formation of Reactive Oxygen Species by Helmerhorst, Eva J., Troxler, Robert F., Oppenheim, Frank G.

“…Previous studies have shown that the human salivary antifungal peptide histatin 5 is taken up by Candida albicans cells and associates intracellularly with…”
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Influence of Histatin 5 on Candida albicans Mitochondrial Protein Expression Assessed by Quantitative Mass Spectrometry by Komatsu, Tomoko, Salih, Erdjan, Helmerhorst, Eva J, Offner, Gwynneth D, Oppenheim, Frank G

“…Individual aspects of the mode of action of histatin 5, a human salivary antifungal protein, have been partially elucidated, but the mechanism likely involves…”
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Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray by Liu, Zheng, Kim, Jean, Sypek, Joseph P., Wang, I-Ming, Horton, Heidi, Oppenheim, Frank G., Bochner, Bruce S.

“…Nasal polyposis (NP) is a chronic inflammatory disease of the sinuses. Its pathogenesis is unknown. DNA microarray analysis allows simultaneous measurement of…”
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Microsensor Arrays for Saliva Diagnostics by WALT, DAVID R., BLICHARZ, TIMOTHY M., HAYMAN, RYAN B., RISSIN, DAVID M., BOWDEN, MICHAELA, SIQUEIRA, WALTER L., HELMERHORST, EVA J., GRAND-PIERRE, NERLINE, OPPENHEIM, FRANK G., BHATIA, JASVINDER S., LITTLE, FRÉDÉRIC F., BRODY, JEROME S.

“…:  Optical fiber microarrays have been used to screen saliva from patients with end‐stage renal disease (ESRD) to ascertain the efficacy of dialysis. We have…”
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