Search Results - "Opp, Mark R."

Sleep Health: Reciprocal Regulation of Sleep and Innate Immunity by Irwin, Michael R, Opp, Mark R

“…Sleep disturbances including insomnia independently contribute to risk of inflammatory disorders and major depressive disorder. This review and overview…”
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How (and why) the immune system makes us sleep by Opp, Mark R, Imeri, Luca

“…Key Points Serotonin promotes wakefulness but is necessary for sleep. Cytokines, such as interleukin 1 (IL-1) and tumor necrosis factor, are involved in…”
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Multielectrode array characterization of human induced pluripotent stem cell derived neurons in co-culture with primary human astrocytes by Lemieux, Maddie R, Freigassner, Bernhard, Hanson, Jessica L, Thathey, Zahra, Opp, Mark R, Hoeffer, Charles A, Link, Christopher D

“…Human induced pluripotent stem cells (hiPSCs) derived into neurons offer a powerful in vitro model to study cellular processes. One method to characterize…”
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The importance of including both sexes in preclinical sleep studies and analyses by Mannino, Grant S., Green, Tabitha R. F., Murphy, Sean M., Donohue, Kevin D., Opp, Mark R., Rowe, Rachel K.

“…A significant effort in biomedical sciences has been made to examine relationships between sex and the mechanisms underlying various disease states and…”
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Sleep fragmentation exacerbates mechanical hypersensitivity and alters subsequent sleep-wake behavior in a mouse model of musculoskeletal sensitization by Sutton, Blair C, Opp, Mark R

“…Sleep deprivation, or sleep disruption, enhances pain in human subjects. Chronic musculoskeletal pain is prevalent in our society, and constitutes a tremendous…”
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Sleeping to fuel the immune system: mammalian sleep and resistance to parasites by Opp, Mark R

“…Sleep is an enigma. Why animals forgo eating and reproducing, while potentially increasing their risk of predation remains unknown. Although some may question…”
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Acute sleep deprivation in mice generates protein pathology consistent with neurodegenerative diseases by Rowe, Rachel K, Schulz, Philip, He, Ping, Mannino, Grant S, Opp, Mark R, Sierks, Michael R

“…Insufficient or disturbed sleep is strongly associated with adverse health conditions, including various neurodegenerative disorders. While the relationship…”
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Sepsis-induced morbidity in mice: Effects on body temperature, body weight, cage activity, social behavior and cytokines in brain by Granger, Jill I, Ratti, Pietro-Luca, Datta, Subhash C, Raymond, Richard M, Opp, Mark R

“…Summary Infection negatively impacts mental health, as evidenced by the lethargy, malaise, and cognitive deficits experienced during illness. These changes in…”
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The neuron-specific interleukin-1 receptor accessory protein is required for homeostatic sleep and sleep responses to influenza viral challenge in mice by Davis, Christopher J, Dunbrasky, Danielle, Oonk, Marcella, Taishi, Ping, Opp, Mark R, Krueger, James M

“…Abstract Interleukin-1β (IL1) is involved in sleep regulation and sleep responses induced by influenza virus. The IL1 receptor accessory protein (AcP) and an…”
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Selective contributions of neuronal and astroglial interleukin-1 receptor 1 to the regulation of sleep by Ingiosi, Ashley M, Raymond, Richard M, Pavlova, Maria N, Opp, Mark R

“…Highlights • Transgenic mice were used to study cell-specific contributions of IL1R1 to sleep. • Transgenic IL1R1 mice have more REMS and enhanced NREMS delta…”
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Microglia Are Necessary to Regulate Sleep after an Immune Challenge by Rowe, Rachel K, Green, Tabitha R F, Giordano, Katherine R, Ortiz, J Bryce, Murphy, Sean M, Opp, Mark R

“…Microglia play a critical role in the neuroimmune response, but little is known about the role of microglia in sleep following an inflammatory trigger…”
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Sleep: Not getting enough diminishes vaccine responses by Opp, Mark R.

“…Vaccine failure is a multifactorial global public health problem. A new meta-analysis underscores the role of sleep history as a factor involved in antibody…”
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Effects of Sleep Disruption and High Fat Intake on Glucose Metabolism in Mice by Ho, Jacqueline M, Barf, R. Paulien, Opp, Mark R

“…Highlights • Sleep fragmentation for 18-h per day reduces time in REMS and NREMS with dialy rebounds in REMS. • NREMS rebound occurs only during the 24-h…”
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Wnt10b Inhibits Development of White and Brown Adipose Tissues by Longo, Kenneth A, Wright, Wendy S, Kang, Sona, Gerin, Isabelle, Chiang, Shian-Huey, Lucas, Peter C, Opp, Mark R, MacDougald, Ormond A

“…Wnt is a family of secreted signaling proteins that regulate diverse developmental processes. Activation of canonical Wnt signaling by Wnt10b inhibits…”
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Sex differences in sleep, anhedonia, and HPA axis activity in a rat model of chronic social defeat by Page, Gayle G., Opp, Mark R., Kozachik, Sharon L.

“…Repeated bouts of a major stressor such as social defeat are well known to induce a depression phenotype in male rats. Despite strong evidence and…”
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Sepsis-induced alterations in sleep of rats by Baracchi, Francesca, Ingiosi, Ashley M, Raymond, Jr, Richard M, Opp, Mark R

“…Sepsis is a systemic immune response to infection that may result in multiple organ failure and death. Polymicrobial infections remain a serious clinical…”
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Sleep and Psychoneuroimmunology by Opp, Mark R., PhD

“…The brain uses a variety of mechanisms to survey the immune system constantly. Responses of the immune system to invading pathogens are detected by the central…”
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Repeated exposure to conditioned fear stress increases anxiety and delays sleep recovery following exposure to an acute traumatic stressor by Greenwood, Benjamin N, Thompson, Robert S, Opp, Mark R, Fleshner, Monika

“…Repeated stressor exposure can sensitize physiological responses to novel stressors and facilitate the development of stress-related psychiatric disorders…”
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Hypocretinergic and cholinergic contributions to sleep-wake disturbances in a mouse model of traumatic brain injury by Thomasy, Hannah E, Febinger, Heidi Y, Ringgold, Kristyn M, Gemma, Carmelina, Opp, Mark R

“…Disorders of sleep and wakefulness occur in the majority of individuals who have experienced traumatic brain injury (TBI), with increased sleep need and…”
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Cytokines and sleep by Opp, Mark R.

“…Personal experience and empirical data indicate sleep is altered during sickness. Important signaling molecules of the peripheral immune system called…”
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