Search Results - "Opland, Darren"

Leptin Action via Neurotensin Neurons Controls Orexin, the Mesolimbic Dopamine System and Energy Balance by Leinninger, Gina M., Opland, Darren M., Jo, Young-Hwan, Faouzi, Miro, Christensen, Lyndsay, Cappellucci, Laura A., Rhodes, Christopher J., Gnegy, Margaret E., Becker, Jill B., Pothos, Emmanuel N., Seasholtz, Audrey F., Thompson, Robert C., Myers, Martin G.

“…Leptin acts on leptin receptor (LepRb)-expressing neurons throughout the brain, but the roles for many populations of LepRb neurons in modulating energy…”
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Leptin Acts via Leptin Receptor-Expressing Lateral Hypothalamic Neurons to Modulate the Mesolimbic Dopamine System and Suppress Feeding by Leinninger, Gina M., Jo, Young-Hwan, Leshan, Rebecca L., Louis, Gwendolyn W., Yang, Hongyan, Barrera, Jason G., Wilson, Hilary, Opland, Darren M., Faouzi, Miro A., Gong, Yusong, Jones, Justin C., Rhodes, Christopher J., Chua, Streamson, Diano, Sabrina, Horvath, Tamas L., Seeley, Randy J., Becker, Jill B., Münzberg, Heike, Myers, Martin G.

“…The lateral hypothalamic area (LHA) acts in concert with the ventral tegmental area (VTA) and other components of the mesolimbic dopamine (DA) system to…”
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Conditional Gene Targeting in Mouse Pancreatic β-cells: Analysis of Ectopic Cre Transgene Expression in the Brain by WICKSTEED, Barton, BRISSOVA, Marcela, BERNAL-MIZRACHI, Ernesto, ELGHAZI, Lynda, ROE, Michael W, LABOSKY, Patricia A, MYERS, Martin G, GANNON, Maureen, POWERS, Alvin C, DEMPSEY, Peter J, WENBO YAN, OPLAND, Darren M, PLANK, Jennifer L, REINERT, Rachel B, DICKSON, Lorna M, TAMARINA, Natalia A, PHILIPSON, Louis H, SHOSTAK, Alena

“…OBJECTIVE--Conditional gene targeting has been extensively used for in vivo analysis of gene function in β-cell biology. The objective of this study was to…”
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Modulation of the mesolimbic dopamine system by leptin by Opland, Darren M, Leinninger, Gina M, Myers,, Martin G

“…Abstract Nutritional status modulates many forms of reward-seeking behavior, with caloric restriction increasing the drive for drugs of abuse as well as for…”
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Neuropeptide Y Activity in the Nucleus Accumbens Modulates Feeding Behavior and Neuronal Activity by van den Heuvel, José K, Furman, Kara, Gumbs, Myrtille C.R, Eggels, Leslie, Opland, Darren M, Land, Benjamin B, Kolk, Sharon M, S. Narayanan, Nandakumar, Fliers, Eric, Kalsbeek, Andries, DiLeone, Ralph J, la Fleur, Susanne E

“…Abstract Background Neuropeptide Y (NPY) is a hypothalamic neuropeptide that plays a prominent role in feeding and energy homeostasis. Expression of the NPY Y1…”
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Ventral tegmental area leptin receptor neurons specifically project to and regulate cocaine- and amphetamine-regulated transcript neurons of the extended central amygdala by Leshan, Rebecca L, Opland, Darren M, Louis, Gwendolyn W, Leinninger, Gina M, Patterson, Christa M, Rhodes, Christopher J, Münzberg, Heike, Myers, Jr, Martin G

“…Leptin acts via its receptor (LepRb) to regulate neural circuits in concert with body energy stores. In addition to acting on a number of hypothalamic…”
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Critical Role for Hypothalamic mTOR Activity in Energy Balance by Mori, Hiroyuki, Inoki, Ken, Münzberg, Heike, Opland, Darren, Faouzi, Miro, Villanueva, Eneida C., Ikenoue, Tsuneo, Kwiatkowski, David, MacDougald, Ormond A., Myers, Martin G., Guan, Kun-Liang

“…The mammalian target of rapamycin (mTOR) promotes anabolic cellular processes in response to growth factors and metabolic cues. The TSC1 and TSC2 tumor…”
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Pten deletion in RIP-Cre neurons protects against type 2 diabetes by activating the anti-inflammatory reflex by Wang, Linyuan, Opland, Darren, Tsai, Sue, Luk, Cynthia T, Schroer, Stephanie A, Allison, Margaret B, Elia, Andrew J, Furlonger, Caren, Suzuki, Akira, Paige, Christopher J, Mak, Tak W, Winer, Daniel A, Myers, Martin G, Woo, Minna

“…A new study by Minna Woo and colleagues shows that a neuronal relay from the brain to the adipose tissue regulates whole-body insulin sensitivity by affecting…”
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Loss of neurotensin receptor-1 disrupts the control of the mesolimbic dopamine system by leptin and promotes hedonic feeding and obesity by Opland, Darren, Sutton, Amy, Woodworth, Hillary, Brown, Juliette, Bugescu, Raluca, Garcia, Adriana, Christensen, Lyndsay, Rhodes, Christopher, Myers, Martin, Leinninger, Gina

“…Abstract Neurons of the lateral hypothalamic area (LHA) control motivated behaviors such as feeding and ambulatory activity, in part by modulating mesolimbic…”
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The islet estrogen receptor-α is induced by hyperglycemia and protects against oxidative stress-induced insulin-deficient diabetes by Kilic, Gamze, Alvarez-Mercado, Ana I, Zarrouki, Bader, Opland, Darren, Liew, Chong Wee, Alonso, Laura C, Myers, Jr, Martin G, Jonas, Jean-Christophe, Poitout, Vincent, Kulkarni, Rohit N, Mauvais-Jarvis, Franck

“…The female steroid, 17β-estradiol (E2), is important for pancreatic β-cell function and acts via at least three estrogen receptors (ER), ERα, ERβ, and the…”
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Regulation of Vascular Endothelial Growth Factor Expression and Vascularization in the Myocardium by Insulin Receptor and PI3K/Akt Pathways in Insulin Resistance and Ischemia by He, Zhiheng, Opland, Darren M, Way, Kerrie J, Ueki, Kohjiro, Bodyak, Natalya, Kang, Peter M, Izumo, Seigo, Kulkarni, Rohit N, Wang, Bo, Liao, Ronglih, Kahn, C Ronald, King, George L

“…OBJECTIVE—This study characterized the role of insulin receptors and resistance on vascular endothelial growth factor (VEGF) expression and myocardial…”
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Differential Regulation of Angiotensin II-induced Expression of Connective Tissue Growth Factor by Protein Kinase C Isoforms in the Myocardium by He, Zhiheng, Way, Kerrie J., Arikawa, Emi, Chou, Eva, Opland, Darren M., Clermont, Allen, Isshiki, Keiji, Ma, Ronald C.W., Scott, Joshua A., Schoen, Frederick J., Feener, Edward P., King, George L.

“…Protein kinase C (PKC) and angiotensin II (AngII) can regulate cardiac function in pathological conditions such as in diabetes or ischemic heart disease. We…”
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Characterization of Multiple Signaling Pathways of Insulin in the Regulation of Vascular Endothelial Growth Factor Expression in Vascular Cells and Angiogenesis by Jiang, Zhen Y., He, Zhiheng, King, Benjamin L., Kuroki, Tatsuya, Opland, Darren M., Suzuma, Kiyoshi, Suzuma, Izumi, Ueki, Kohjiro, Kulkarni, Rohit N., Kahn, C.Ronald, King, George L.

“…The effects of insulin on vascular endothelial growth factor (VEGF) expression in cultured vascular cells and in angiogenesis were characterized. Insulin…”
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Carcinoembryonic Antigen-Related Cell Adhesion Molecule 2 Controls Energy Balance and Peripheral Insulin Action in Mice by Heinrich, Garrett, Ghosh, Sumona, DeAngelis, Anthony M, Schroeder–Gloeckler, Jill M, Patel, Payal R, Castaneda, Tamara R, Jeffers, Shane, Lee, Abraham D, Jung, Dae Young, Zhang, Zhiyou, Opland, Darren M, Myers, Martin G, Kim, Jason K, Najjar, Sonia M

“…Background & Aims The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a transmembrane glycoprotein with pleotropic functions, including…”
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Critical roles for the TSC-mTOR pathway in β-cell function by Mori, Hiroyuki, Inoki, Ken, Opland, Darren, Münzberg, Heike, Villanueva, Eneida C, Faouzi, Miro, Ikenoue, Tsuneo, Kwiatkowski, David J, Macdougald, Ormond A, Myers, Jr, Martin G, Guan, Kun-Liang

“…TSC1 is a tumor suppressor that associates with TSC2 to inactivate Rheb, thereby inhibiting signaling by the mammalian target of rapamycin (mTOR) complex 1…”
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Importance of β-Catenin in glucose and energy homeostasis by Elghazi, Lynda, Gould, Aaron P., Weiss, Aaron J., Barker, Daniel J., Callaghan, John, Opland, Darren, Myers, Martin, Cras-Méneur, Corentin, Bernal-Mizrachi, Ernesto

“…In settings of increased insulin demand, failure to expand pancreatic β-cells mass leads to diabetes. Genome-wide scans of diabetic populations have uncovered…”
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Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic states: A possible explanation for impaired collateral formation in cardiac tissue by CHOU, Eva, SUZUMA, Izumi, KING, George L, WAY, Kerrie J, OPLAND, Darren, CLERMONT, Allen C, NARUSE, Keiko, SUZUMA, Kiyoshi, BOWLING, Nancy L, VLAHOS, Chris J, AIELLO, Lloyd Paul

“…Inadequate angiogenic response to ischemia in the myocardium of diabetic patients could result in poor collateral formation. Yet, excessive neovascularization…”
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Modulation of the mesolimbic dopamine system by leptin : Neurobiology of obesity by OPLAND, Darren M, LEINNINGER, Gina M, MYERS, Martin G

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The Islet Estrogen Receptor-[alpha] Is Induced by Hyperglycemia and Protects Against Oxidative Stress-Induced Insulin-Deficient Diabetes by Kilic, Gamze, Alvarez-Mercado, Ana I, Zarrouki, Bader, Opland, Darren, Liew, Chong Wee, Alonso, Laura C, Myers, Martin G, Jonas, Jean-Christophe, Poitout, Vincent, Kulkarni, Rohit N, Mauvais-Jarvis, Franck

“…The female steroid, 17[beta]-estradiol (E2), is important for pancreatic [beta]-cell function and acts via at least three estrogen receptors (ER), ER[alpha],…”
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A Role for CEACAM2 in the Central Control of Energy Balance and Peripheral Insulin Action by Heinrich, Garrett, Ghosh, Sumona, DeAngelis, Anthony M., Schroeder-Gloeckler, Jill M., Patel, Payal R., Castaneda, Tamara R., Jeffers, Shane, Lee, Abraham D., Jung, Dae Young, Zhang, Zhiyou, Opland, Darren M., Myers, Martin G., Kim, Jason K., Najjar, Sonia M.

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