Search Results - "Opipari, A W"

Characterization of the metabolic phenotype of chronically activated lymphocytes by Wahl, DR, Petersen, B., Warner, R., Richardson, BC, Glick, GD, Opipari, AW

“…Activated lymphocytes proliferate, secrete cytokines, and can make antibodies. Normally activated B and T cells meet the bioenergetic demand for these…”
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NF-κB Activation Mediates Doxorubicin-induced Cell Death in N-type Neuroblastoma Cells by Bian, Xin, McAllister-Lucas, Linda M., Shao, Feng, Schumacher, Kurt R., Feng, Zhiwei, Porter, Alan G., Castle, Valerie P., Opipari, Anthony W.

“…Neuroblastoma is the most common extracranial solid tumor of childhood. N-type neuroblastoma cells (represented by SH-SY5Y and IMR32 cell lines) are…”
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The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity by A W Opipari, Jr, H M Hu, R Yabkowitz, V M Dixit

“…Resistance against the cytotoxic actions of tumor necrosis factor alpha (TNF) is an active process requiring the synthesis of TNF-inducible proteins. The…”
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Sensitive Detection of Human Papillomavirus in Cervical, Head/Neck, and Schistosomiasis-Associated Bladder Malignancies by Yang, H., Yang, K., Khafagi, A., Tang, Y., Carey, T. E., Opipari, A. W., Lieberman, R., Oeth, P. A., Lancaster, W., Klinger, H. P., Kaseb, A. O., Metwally, A., Khaled, H., Kurnit, D. M., Cantor, Charles R.

“…We assayed for the presence of human papilloma virus (HPV) DNA in serum and/or peripheral blood fraction (PBF) of individuals with cervical, head/neck, or…”
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The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein by A W Opipari, Jr, M S Boguski, V M Dixit

“…We have previously identified in endothelial cells a gene product designated A20, that is rapidly and profoundly induced by tumor necrosis factor alpha (Dixit,…”
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The Epstein-Barr virus LMP1 gene product induces A20 zinc finger protein expression by activating nuclear factor kappa B by Laherty, C D, Hu, H M, Opipari, A W, Wang, F, Dixit, V M

“…A20 is an inducible zinc finger protein that confers resistance to tumor necrosis factor alpha cytotoxicity. A survey of various cell lines revealed that A20…”
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Chemotherapy-induced Apoptosis of S-type Neuroblastoma Cells Requires Caspase-9 and Is Augmented by CD95/Fas Stimulation by Bian, Xin, Giordano, Thomas D., Lin, Huey-Jen, Solomon, Gabriel, Castle, Valerie P., Opipari, Anthony W.

“…Stromal or S-type tumor cells are a distinct lineage found in neuroblastoma tumors and have an important role in the biology of this disease. Anticancer agents…”
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A Novel Benzodiazepine Increases the Sensitivity of B Cells to Receptor Stimulation with Synergistic Effects on Calcium Signaling and Apoptosis by Bednarski, Jeffrey J, Lyssiotis, Costas A, Roush, Rebecca, Boitano, Anthony E, Glick, Gary D, Opipari, Jr, Anthony W

“…Bz-423 is a 1,4-benzodiazepine with selective lymphotoxic properties and potent therapeutic activity against lupus-like disease in autoimmune mice. In NZB/W…”
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HDAC6 deacetylates Ku70 and regulates Ku-Bax binding in neuroblastoma by Subramanian, C, Jazembowski, JA, Opipari, A W, Castle, V P, Kwok, R P

“…Ku70 was first characterized as a nuclear factor that binds DNA double strand breaks in non-homologue end-joining DNA repair. However, recent studies have…”
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Resveratrol-induced autophagocytosis in ovarian cancer cells by OPIPARI, Anthony W, LIJUN TAN, BOITANO, Anthony E, SORENSON, Dorothy R, AURORA, Anjili, LIU, J. Rebecca

“…Resveratrol (3,5,4-trihydroxystilbene), a natural phytoalexin present in grapes, nuts, and red wine, has antineoplastic activities. Several molecular…”
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CREB-Binding Protein Is a Mediator of Neuroblastoma Cell Death Induced By the Histone Deacetylase Inhibitor Trichostatin A by Subramanian, Chitra, Jarzembowski, Jason A., Opipari, Anthony W., Castle, Valerie P., Kwok, Roland P.S.

“…The cytotoxic mechanism of the histone deacetylase inhibitor (HDACI) Trichostatin A (TSA) was explored in a neuroblastoma (NB) model. TSA induces cell death in…”
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Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition : Therapeutic implications by FERNANDEZ, Yolanda, VERHAEGEN, Monique, MILLER, Thomas P, RUSH, Jenny L, STEINER, Philipp, OPIPARI, Anthony W, LOWE, Scott W, SOENGAS, Maria S

“…Melanoma is the most aggressive form of skin cancer and advanced stages are invariably resistant to conventional therapeutic agents. Using bortezomib as a…”
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Development and evaluation of a PCR and mass spectroscopy (PCR–MS)-based method for quantitative, type-specific detection of human papillomavirus by Patel, Divya A., Shih, Yang-Jen, Newton, Duane W., Michael, Claire W., Oeth, Paul A., Kane, Michael D., Opipari, Anthony W., Ruffin, IV, Mack T., Kalikin, Linda M., Kurnit, David M.

“…Knowledge of the central role of high-risk human papillomavirus (HPV) in cervical carcinogenesis, coupled with an emerging need to monitor the efficacy of…”
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Ku70 Acetylation Mediates Neuroblastoma Cell Death Induced by Histone Deacetylase Inhibitors by Subramanian, Chitra, Opipari, Anthony W., Bian, Xin, Castle, Valerie P., Roland P. S. Kwok, Goodman, Richard H.

“…Histone deacetylase inhibitors (HDACIs) are therapeutic drugs that inhibit deacetylase activity, thereby increasing acetylation of many proteins, including…”
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Signaling from p53 to NF-κB Determines the Chemotherapy Responsiveness of Neuroblastoma by Armstrong, Michael B., Bian, Xin, Liu, Yihong, Subramanian, Chitra, Ratanaproeksa, Anthony B., Shao, Feng, Yu, Victor C., Kwok, Roland P.S., Opipari, Anthony W., Castle, Valerie P.

“…Neuroblastic (N) type neuroblastoma (NB) is the predominant cell type in NB tumors. Previously, we determined that activated nuclear factor κB (NF-κB) is…”
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Dysfunctional apoptosome activation in ovarian cancer: Implications for chemoresistance by LIU, J. Rebecca, OPIPARI, Anthony W, LIJUN TAN, YIBIN JIANG, YUJING ZHANG, HUAIJING TANG, NUNEZ, Gabriel

“…Alterations in the regulation of apoptosis may contribute to the pathogenesis of cancer and resistance of tumor cells to chemotherapy. In mammalian cells,…”
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Constitutively Active NFκB Is Required for the Survival of S-type Neuroblastoma by Bian, Xin, Opipari, Anthony W., Ratanaproeksa, Anthony B., Boitano, Anthony E., Lucas, Peter C., Castle, Valerie P.

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The immunomodulatory benzodiazepine Bz-423 inhibits B-cell proliferation by targeting c-myc protein for rapid and specific degradation by SUNDBERG, Thomas B, NEY, Gina M, SUBRAMANIAN, Chitra, OPIPARI, Anthony W, GLICK, Gary D

“…Myc proteins regulate cell growth and are oncogenic in many cancers. Although these proteins are validated molecular anticancer targets, new therapies aimed at…”
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The proapoptotic benzodiazepine Bz-423 affects the growth and survival of malignant B cells by BOITANO, Anthony, ELLMAN, Jonathan A, GLICK, Gary D, OPIPARI, Anthony W

“…Bz-423 is a novel proapoptotic 1,4-benzodiazepine that induces cell death via a superoxide signal. Previous work has shown that Bz-423 ameliorates disease in…”
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Identification of cytotoxic, T-cell-selective 1,4-benzodiazepine-2,5-diones by Francis, Tasha M., Sundberg, Thomas B., Cleary, Joanne, Groendyke, Todd, Opipari, Anthony W., Glick, Gary D.

“…A 1,4-benzodiazepine-2,5-dione (BZD) library was evaluated for lymphotoxic members. When the C3 substituent contains an electron-rich heterocycle, the…”
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