Search Results - "Opezzo, Javier A.W."

Increased delivery of chemotherapy to the vitreous by inhibition of the blood-retinal barrier by Pascual-Pasto, Guillem, Olaciregui, Nagore G., Opezzo, Javier A.W., Castillo-Ecija, Helena, Cuadrado-Vilanova, Maria, Paco, Sonia, Rivero, Ezequiel M., Vila-Ubach, Monica, Restrepo-Perdomo, Camilo A., Torrebadell, Montserrat, Suñol, Mariona, Schaiquevich, Paula, Mora, Jaume, Bramuglia, Guillermo F., Chantada, Guillermo L., Carcaboso, Angel M.

“…Treatment of retinoblastoma -a pediatric cancer of the developing retina- might benefit from strategies to inhibit the blood-retinal barrier (BRB). The potent…”
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Study of the hypothalamic angiotensin system in aortic coarctated rats using the reverse microdialysis technique by Höcht, Christian, Opezzo, Javier A.W, Gironacci, Mariela, Peña, Clara, Taira, Carlos A

“…The objective of our work was to study the intrahypothalamic actions of irbesartan, an angiotensin receptor antagonist, on blood pressure and dopaminergic and…”
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In vivo and in vitro pharmacodynamic properties of metoprolol in aortic coarctated rats by Höcht, Christian, Verniero, Carla Di, Opezzo, Javier A.W, Taira, Carlos A

“…The chronotropic effects of metoprolol (MP) in vivo after intravenous administration and in vitro in isolated atria of aortic coarctated rats were studied. MP…”
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Intranasal administration of antiretroviral-loaded micelles for anatomical targeting to the brain in HIV by Chiappetta, Diego A, Hocht, Christian, Opezzo, Javier A W, Sosnik, Alejandro

“…To investigate the intranasal administration of poly(ethylene oxide)-poly(propylene oxide) polymeric micelles loaded with high payloads of the first-line…”
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Episcleral Implants for Topotecan Delivery to the Posterior Segment of the Eye by Carcaboso, Angel M, Chiappetta, Diego A, Opezzo, Javier A. W, Hocht, Christian, Fandino, Adriana C, Croxatto, J. Oscar, Rubio, Modesto C, Sosnik, Alejandro, Abramson, David H, Bramuglia, Guillermo F, Chantada, Guillermo L

“…Purpose. Intravenous or periocular topotecan has been proposed as new treatment modality for patients with advanced intraocular retinoblastoma, but systemic…”
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Nimodipine restores the altered hippocampal phenytoin pharmacokinetics in a refractory epileptic model by Höcht, Christian, Lazarowski, Alberto, Gonzalez, Nélida N., Auzmendi, Jerónimo, Opezzo, Javier A.W., Bramuglia, Guillermo F., Taira, Carlos A., Girardi, Elena

“…The present work was undertaken to examine the central pharmacokinetics of phenytoin (PHT) in an experimental model of epilepsy, induced by administration of…”
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Applicability of reverse microdialysis in pharmacological and toxicological studies by Höcht, Christian, Opezzo, Javier A.W., Taira, Carlos A.

“…A recent application of microdialysis is the introduction of a substance into the extracellular space via the microdialysis probe. The inclusion of a higher…”
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Differential hippocampal pharmacokinetics of phenobarbital and carbamazepine in repetitive seizures induced by 3-mercaptopropionic acid by Höcht, Christian, Lazarowski, Alberto, Gonzalez, Nélida N., Mayer, Marcos A., Opezzo, Javier A.W., Taira, Carlos A., Girardi, Elena

“…Previous evidence has shown that chronic 3-mercaptopropionic acid (MP) administration induced brain P-glycoprotein (P-gp) overexpression altering target site…”
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Cardiovascular drugs inducing QT prolongation: facts and evidence by Taira, Carlos A, Opezzo, Javier A W, Mayer, Marcos A, Höcht, Christian

“…Acquired QT syndrome is mainly caused by the administration of drugs that prolong ventricular repolarization. On the other hand, the risk of drug-induced…”
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Increased sensitivity to diltiazem hypotensive effect in an experimental model of high-renin hypertension by Bertera, Facundo M., Mayer, Marcos A., Opezzo, Javier A.W., Taira, Carlos A., Höcht, Christian

“…Objectives The aim of this work was to evaluate the pharmacokinetic–pharmacodynamic properties of diltiazem in an experimental model of high‐renin…”
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Pharmacokinetic-pharmacodynamic (PK-PD) modeling of cardiovascular effects of metoprolol in spontaneously hypertensive rats: a microdialysis study by Höcht, Christian, Di Verniero, Carla, Opezzo, Javier A W, Bramuglia, Guillermo F, Taira, Carlos A

“…The present work addressed possible alterations in the pharmacokinetics and the in vivo pharmacodynamic of metoprolol (MET) in spontaneously hypertensive (SH)…”
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Pharmacokinetic–pharmacodynamic modeling of diltiazem in spontaneously hypertensive rats: A microdialysis study by Bertera, Facundo M., Mayer, Marcos A., Opezzo, Javier A.W., Taira, Carlos A., Bramuglia, Guillermo F., Höcht, Christian

“…The aim of the present work was to study the applicability of a modified E max pharmacodynamic model for the pharmacokinetic-pharmacodynamic (PK–PD) modeling…”
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Hypothalamic angiotensinergic-noradrenergic systems interaction in fructose induced hypertension by MAYER, Marcos A, HÖCHT, Christian, GIRONACCI, Mariela, OPEZZO, Javier A. W, TAIRA, Carlos A, FERNANDEZ, Belisario E, PUYO, Ana M

“…Several studies suggest the importance of the interaction between the renin angiotensin and sympathetic nervous systems in blood pressure control, especially…”
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Comparison of different pharmacodynamic models for PK–PD modeling of verapamil in renovascular hypertension by Bertera, Facundo M., Mayer, Marcos A., Opezzo, Javier A.W., Taira, Carlos A., Höcht, Christian

“…The aim of this work was to compare the suitability of different pharmacodynamic models for PK–PD modeling of verapamil cardiovascular effects in aortic…”
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Hypothalamic cardiovascular effects of angiotensin-(1–7) in spontaneously hypertensive rats by Höcht, Christian, Opezzo, Javier A.W., Gironacci, Mariela M., Peña, Clara, Taira, Carlos A.

“…The objective of the present work was to study the cardiovascular actions of the intrahypothalamic injection of Ang-(1–7) and its effects on the pressor…”
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Applicability of microdialysis as a technique for pharmacokinetic–pharmacodynamic (PK–PD) modeling of antihypertensive beta-blockers by Höcht, Christian, DiVerniero, Carla, Opezzo, Javier A.W., Taira, Carlos A.

“…The aim of the present work was to examine microdialysis as a technique for the study of pharmacokinetic–pharmacodynamic modeling of antihypertensive drugs…”
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CHANGES IN THE IN VITRO PHARMACODYNAMIC PROPERTIES OF METOPROLOL IN ATRIA ISOLATED FROM SPONTANEOUSLY HYPERTENSIVE RATS by Di Verniero, Carla, Höcht, Christian, Opezzo, Javier A W, Taira, Carlos A

“…SUMMARY 1 The present study addressed possible changes in the dissociation constant of metoprolol and its inverse agonist activity in spontaneously…”
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ROLE OF HYPOTHALAMIC α2-ADRENOCEPTOR ACTIVITY IN FRUCTOSE-INDUCED HYPERTENSION by Mayer, Marcos A, Höcht, Christian, Opezzo, Javier AW, Peredo, Horacio A, Navacchia, Daniel, Taira, Carlos A, Fernández, Belisario E, Puyó, Ana M

“…SUMMARY 1 The aim of the present study was to investigate the effects of the α2‐adrenoceptor antagonist yohimbine on blood pressure and heart rate (HR)…”
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Pharmacokinetic-pharmacodynamic properties of metoprolol in chronic aortic coarctated rats by Höcht, Christian, Di Verniero, Carla, Opezzo, Javier A W, Taira, Carlos A

“…The present study addressed possible alterations in the pharmacodynamic and pharmacokinetic properties of the beta1-adrenoceptor antagonist metoprolol in…”
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HYPOTHALAMIC ANTIHYPERTENSIVE EFFECT OF METOPROLOL IN CHRONIC AORTIC COARCTATED RATS by Höcht, Christian, Opezzo, Javier AW, Taira, Carlos A

“…SUMMARY 1. The aim of the present study was to investigate the possible hypothalamic antihypertensive effect of metoprolol and its action on aminergic…”
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