Search Results - "Openshaw, Peter J. M"

Outcome of COVID-19 in hospitalised immunocompromised patients: An analysis of the WHO ISARIC CCP-UK prospective cohort study by Turtle, Lance, Thorpe, Mathew, Drake, Thomas M, Swets, Maaike, Palmieri, Carlo, Russell, Clark D, Ho, Antonia, Aston, Stephen, Wootton, Daniel G, Richter, Alex, de Silva, Thushan I, Hardwick, Hayley E, Leeming, Gary, Law, Andy, Openshaw, Peter J M, Harrison, Ewen M, Baillie, J Kenneth, Semple, Malcolm G, Docherty, Annemarie B

“…Immunocompromised patients may be at higher risk of mortality if hospitalised with Coronavirus Disease 2019 (COVID-19) compared with immunocompetent patients…”
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Alpha/beta interferon receptor signaling amplifies early proinflammatory cytokine production in the lung during respiratory syncytial virus infection by Goritzka, Michelle, Durant, Lydia R, Pereira, Catherine, Salek-Ardakani, Samira, Openshaw, Peter J M, Johansson, Cecilia

“…Type I interferons (IFNs) are produced early upon virus infection and signal through the alpha/beta interferon (IFN-α/β) receptor (IFNAR) to induce genes that…”
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Bronchiolitis by Smyth, Rosalind L, Openshaw, Peter JM

“…Bronchiolitis is a distressing, potentially life-threatening respiratory condition that affects young babies. Around 2–3% of all infants younger than 1 year…”
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Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection by OPENSHAW, Peter J. M, TREGONING, John S

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Alveolar Macrophages Are a Major Determinant of Early Responses to Viral Lung Infection but Do Not Influence Subsequent Disease Development by PRIBUL, Philippa K, HARKER, James, WANG, Belinda, HONGWEI WANG, TREGONING, John S, SCHWARZE, Jürgen, OPENSHAW, Peter J. M

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Targeted metagenomics reveals association between severity and pathogen co-detection in infants with respiratory syncytial virus by Lin, Gu-Lung, Drysdale, Simon B., Snape, Matthew D., O’Connor, Daniel, Brown, Anthony, MacIntyre-Cockett, George, Mellado-Gomez, Esther, de Cesare, Mariateresa, Ansari, M. Azim, Bonsall, David, Bray, James E., Jolley, Keith A., Bowden, Rory, Aerssens, Jeroen, Bont, Louis, Openshaw, Peter J. M., Martinon-Torres, Federico, Nair, Harish, Golubchik, Tanya, Pollard, Andrew J.

“…Respiratory syncytial virus (RSV) is the leading cause of hospitalisation for respiratory infection in young children. RSV disease severity is known to be…”
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Early mucosal events promote distinct mucosal and systemic antibody responses to live attenuated influenza vaccine by Thwaites, Ryan S., Uruchurtu, Ashley S. S., Negri, Victor Augusti, Cole, Megan E., Singh, Nehmat, Poshai, Nelisa, Jackson, David, Hoschler, Katja, Baker, Tina, Scott, Ian C., Ros, Xavier Romero, Cohen, Emma Suzanne, Zambon, Maria, Pollock, Katrina M., Hansel, Trevor T., Openshaw, Peter J. M.

“…Compared to intramuscular vaccines, nasally administered vaccines have the advantage of inducing local mucosal immune responses that may block infection and…”
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Obesity dysregulates the pulmonary antiviral immune response by Almond, Mark, Farne, Hugo A., Jackson, Millie M., Jha, Akhilesh, Katsoulis, Orestis, Pitts, Oliver, Tunstall, Tanushree, Regis, Eteri, Dunning, Jake, Byrne, Adam J., Mallia, Patrick, Kon, Onn Min, Saunders, Ken A., Simpson, Karen D., Snelgrove, Robert J., Openshaw, Peter J. M., Edwards, Michael R., Barclay, Wendy S., Heaney, Liam M., Johnston, Sebastian L., Singanayagam, Aran

“…Obesity is a well-recognized risk factor for severe influenza infections but the mechanisms underlying susceptibility are poorly understood. Here, we identify…”
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Obesity, chronic disease, age, and in-hospital mortality in patients with covid-19: analysis of ISARIC clinical characterisation protocol UK cohort by Yates, Thomas, Zaccardi, Francesco, Islam, Nazrul, Razieh, Cameron, Gillies, Clare L, Lawson, Claire A, Chudasama, Yogini, Rowlands, Alex, Davies, Melanie J, Docherty, Annemarie B, Openshaw, Peter J M, Baillie, J Kenneth, Semple, Malcolm G, Khunti, Kamlesh

“…Although age, obesity and pre-existing chronic diseases are established risk factors for COVID-19 outcomes, their interactions have not been well researched…”
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Regulatory T Cells Prevent Th2 Immune Responses and Pulmonary Eosinophilia during Respiratory Syncytial Virus Infection in Mice by Durant, Lydia R, Makris, Spyridon, Voorburg, Cornelia Maaike, Loebbermann, Jens, Johansson, Cecilia, Openshaw, Peter J M

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CD25+ Natural Regulatory T Cells Are Critical in Limiting Innate and Adaptive Immunity and Resolving Disease following Respiratory Syncytial Virus Infection by Lee, Debbie C P, Harker, James A E, Tregoning, John S, Atabani, Sowsan F, Johansson, Cecilia, Schwarze, Jürgen, Openshaw, Peter J M

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The Role of T Cells in the Enhancement of Respiratory Syncytial Virus Infection Severity during Adult Reinfection of Neonatally Sensitized Mice by TREGONING, John S, YAMAGUCHI, Yuko, HARKER, James, WANG, Belinda, OPENSHAW, Peter J. M

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Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19 by Peng, Yanchun, Mentzer, Alexander J., Liu, Guihai, Yao, Xuan, Yin, Zixi, Dong, Danning, Dejnirattisai, Wanwisa, Rostron, Timothy, Supasa, Piyada, Liu, Chang, López-Camacho, César, Slon-Campos, Jose, Zhao, Yuguang, Stuart, David I., Paesen, Guido C., Grimes, Jonathan M., Antson, Alfred A., Bayfield, Oliver W., Hawkins, Dorothy E. D. P., Ker, De-Sheng, Wang, Beibei, Turtle, Lance, Subramaniam, Krishanthi, Thomson, Paul, Zhang, Ping, Dold, Christina, Ratcliff, Jeremy, Simmonds, Peter, de Silva, Thushan, Sopp, Paul, Wellington, Dannielle, Rajapaksa, Ushani, Chen, Yi-Ling, Salio, Mariolina, Napolitani, Giorgio, Paes, Wayne, Borrow, Persephone, Kessler, Benedikt M., Fry, Jeremy W., Schwabe, Nikolai F., Semple, Malcolm G., Baillie, J. Kenneth, Moore, Shona C., Openshaw, Peter J. M., Ansari, M. Azim, Dunachie, Susanna, Barnes, Eleanor, Frater, John, Kerr, Georgina, Goulder, Philip, Lockett, Teresa, Levin, Robert, Zhang, Yonghong, Jing, Ronghua, Ho, Ling-Pei, Cornall, Richard J., Conlon, Christopher P., Klenerman, Paul, Screaton, Gavin R., Mongkolsapaya, Juthathip, McMichael, Andrew, Knight, Julian C., Ogg, Graham, Dong, Tao

“…The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We…”
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Delayed Sequelae of Neonatal Respiratory Syncytial Virus Infection Are Dependent on Cells of the Innate Immune System by Harker, James A, Yamaguchi, Yuko, Culley, Fiona J, Tregoning, John S, Openshaw, Peter J M

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Natural killer cell NKG2D and granzyme B are critical for allergic pulmonary inflammation by Farhadi, Nazanin, MSc, Lambert, Laura, BA, Triulzi, Chiara, PhD, Openshaw, Peter J.M., FMedSci, Guerra, Nadia, PhD, Culley, Fiona J., PhD

“…Background The diverse roles of innate immune cells in the pathogenesis of asthma remain to be fully defined. Natural killer (NK) cells are innate lymphocytes…”
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Seasonal and pandemic influenza: 100 years of progress, still much to learn by Dunning, Jake, Thwaites, Ryan S., Openshaw, Peter J. M.

“…Influenza viruses are highly transmissible, both within and between host species. The severity of the disease they cause is highly variable, from the mild and…”
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The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells by Schuijs, Martijn J, Hartmann, Susanne, Selkirk, Murray E, Roberts, Luke B, Openshaw, Peter J M, Schnoeller, Corinna

“…Respiratory Syncytial Virus (RSV) is a major pathogen causing low respiratory tract disease (bronchiolitis), primarily in infants. Helminthic infections may…”
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Tracheostomy in the COVID-19 era: global and multidisciplinary guidance by McGrath, Brendan A, Brenner, Michael J, Warrillow, Stephen J, Pandian, Vinciya, Arora, Asit, Cameron, Tanis S, Añon, José Manuel, Hernández Martínez, Gonzalo, Truog, Robert D, Block, Susan D, Lui, Grace C Y, McDonald, Christine, Rassekh, Christopher H, Atkins, Joshua, Qiang, Li, Vergez, Sébastien, Dulguerov, Pavel, Zenk, Johannes, Antonelli, Massimo, Pelosi, Paolo, Walsh, Brian K, Ward, Erin, Shang, You, Gasparini, Stefano, Donati, Abele, Singer, Mervyn, Openshaw, Peter J M, Tolley, Neil, Markel, Howard, Feller-Kopman, David J

“…Global health care is experiencing an unprecedented surge in the number of critically ill patients who require mechanical ventilation due to the COVID-19…”
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Role of CCL5 (RANTES) in Viral Lung Disease by CULLEY, Fiona J, PENNYCOOK, Alasdair M. J, TREGONING, John S, DODD, Jonathan S, WALZL, Gerhard, WELLS, Timothy N, HUSSELL, Tracy, OPENSHAW, Peter J. M

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Differential Chemokine Expression following Respiratory Virus Infection Reflects Th1- or Th2-Biased Immunopathology by CULLEY, Fiona J, PENNYCOOK, Alasdair M. J, TREGONING, John S, HUSSELL, Tracy, OPENSHAW, Peter J. M

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