Search Results - "Opelt, Marissa"
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1
Irreversible Activation and Stabilization of Soluble Guanylate Cyclase by the Protoporphyrin IX Mimetic Cinaciguat
Published in Molecular pharmacology (01-02-2018)“…Belonging to the class of so-called soluble guanylate cyclase (sGC) activators, cinaciguat and BAY 60-2770 are interesting therapeutic tools for the treatment…”
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2
Formation of Nitric Oxide by Aldehyde Dehydrogenase-2 Is Necessary and Sufficient for Vascular Bioactivation of Nitroglycerin
Published in The Journal of biological chemistry (11-11-2016)“…Aldehyde dehydrogenase-2 (ALDH2) catalyzes vascular bioactivation of the antianginal drug nitroglycerin (GTN), resulting in activation of soluble guanylate…”
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3
Real-time visualization of distinct nitric oxide generation of nitric oxide synthase isoforms in single cells
Published in Nitric oxide (01-11-2017)“…The members of the nitric oxide synthase (NOS) family, eNOS, nNOS and iNOS, are well-characterized enzymes. However, due to the lack of suitable direct NO…”
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4
Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS)
Published in Free radical biology & medicine (01-01-2017)“…Mitochondrial Ca2+ uptake regulates diverse endothelial cell functions and has also been related to nitric oxide (NO•) production. However, it is not entirely…”
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5
Sustained Formation of Nitroglycerin-Derived Nitric Oxide by Aldehyde Dehydrogenase-2 in Vascular Smooth Muscle without Added Reductants: Implications for the Development of Nitrate Tolerance
Published in Molecular pharmacology (01-04-2018)“…According to current views, oxidation of aldehyde dehydrogenase-2 (ALDH2) during glyceryltrinitrate (GTN) biotransformation is essentially involved in vascular…”
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6
Aldehyde dehydrogenase-independent bioactivation of nitroglycerin in porcine and bovine blood vessels
Published in Biochemical pharmacology (15-02-2015)“…The vascular bioactivation of the antianginal drug nitroglycerin (GTN), yielding 1,2-glycerol dinitrate and nitric oxide or a related activator of soluble…”
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7
Intact mitochondrial Ca 2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS)
Published in Free radical biology & medicine (01-01-2017)“…Mitochondrial Ca uptake regulates diverse endothelial cell functions and has also been related to nitric oxide (NO ) production. However, it is not entirely…”
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8
P165 - Aldehyde dehydrogenase-2 independent bioactivation of nitroglycerin in porcine and bovine coronary arteries
Published in Nitric oxide (15-11-2014)Get full text
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9
Aldehyde dehydrogenase-2 independent bioactivation of nitroglycerin in porcine and bovine coronary arteries
Published in Nitric oxide (01-11-2014)Get full text
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