Search Results - "Opazo, Carlos M."

Systematic Review: Quantitative Susceptibility Mapping (QSM) of Brain Iron Profile in Neurodegenerative Diseases by Ravanfar, Parsa, Loi, Samantha M, Syeda, Warda T, Van Rheenen, Tamsyn E, Bush, Ashley I, Desmond, Patricia, Cropley, Vanessa L, Lane, Darius J R, Opazo, Carlos M, Moffat, Bradford A, Velakoulis, Dennis, Pantelis, Christos

“…Iron has been increasingly implicated in the pathology of neurodegenerative diseases. In the past decade, development of the new magnetic resonance imaging…”
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Copper: from neurotransmission to neuroproteostasis by Opazo, Carlos M, Greenough, Mark A, Bush, Ashley I

“…Copper is critical for the Central Nervous System (CNS) development and function. In particular, different studies have shown the effect of copper at brain…”
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Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson's disease by Gallegos, Scarlet, Pacheco, Carla, Peters, Christian, Opazo, Carlos M, Aguayo, Luis G

“…Alpha-synuclein is a presynaptic protein expressed throughout the central nervous system, and it is the main component of Lewy bodies, one of the…”
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Redox active metals in neurodegenerative diseases by Acevedo, Karla, Masaldan, Shashank, Opazo, Carlos M., Bush, Ashley I.

“…Copper (Cu) and iron (Fe) are redox active metals essential for the regulation of cellular pathways that are fundamental for brain function, including…”
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Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons by Castro, Patricio A, Ramirez, Alejandra, Sepúlveda, Fernando J, Peters, Christian, Fierro, Humberto, Waldron, Javier, Luza, Sandra, Fuentealba, Jorge, Muñoz, Francisco J, De Ferrari, Giancarlo V, Bush, Ashley I, Aguayo, Luis G, Opazo, Carlos M

“…Extracellular and intracellular copper and zinc regulate synaptic activity and plasticity, which may impact brain functionality and human behavior. We have…”
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The ubiquitin proteasome system and schizophrenia by Luza, Sandra, Opazo, Carlos M, Bousman, Chad A, Pantelis, Christos, Bush, Ashley I, Everall, Ian P

“…The ubiquitin-proteasome system is a master regulator of neural development and the maintenance of brain structure and function. It influences neurogenesis,…”
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Phosphoproteomics implicates glutamatergic and dopaminergic signalling in the antidepressant-like properties of the iron chelator deferiprone by Uzungil, Volkan, Luza, Sandra, Opazo, Carlos M., Mees, Isaline, Li, Shanshan, Ang, Ching-Seng, Williamson, Nicholas A., Bush, Ashley I., Hannan, Anthony J., Renoir, Thibault

“…Current antidepressants have limitations due to insufficient efficacy and delay before improvement in symptoms. Polymorphisms of the serotonin transporter…”
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Perturbed iron biology in the prefrontal cortex of people with schizophrenia by Lotan, Amit, Luza, Sandra, Opazo, Carlos M., Ayton, Scott, Lane, Darius J. R., Mancuso, Serafino, Pereira, Avril, Sundram, Suresh, Weickert, Cynthia Shannon, Bousman, Chad, Pantelis, Christos, Everall, Ian P., Bush, Ashley I.

“…Despite loss of grey matter volume and emergence of distinct cognitive deficits in young adults diagnosed with schizophrenia, current treatments for…”
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Extracellular α‐synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane by Pacheco, Carla R., Morales, Camila N., Ramírez, Alejandra E., Muñoz, Francisco J., Gallegos, Scarlet S., Caviedes, Pablo A., Aguayo, Luis G., Opazo, Carlos M.

“…It has been postulated that the accumulation of extracellular α‐synuclein (α‐syn) might alter the neuronal membrane by formation of ‘pore‐like structures’ that…”
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Novel Antidepressant-Like Properties of the Iron Chelator Deferiprone in a Mouse Model of Depression by Uzungil, Volkan, Tran, Harvey, Aitken, Connor, Wilson, Carey, Opazo, Carlos M., Li, Shanshan, Payet, Jennyfer M., Mawal, Celeste H., Bush, Ashley I., Hale, Matthew W., Hannan, Anthony J., Renoir, Thibault

“…Depressed individuals who carry the short allele for the serotonin-transporter-linked promotor region of the gene are more vulnerable to stress and have…”
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Elevated ubiquitinated proteins in brain and blood of individuals with schizophrenia by Bousman, Chad A., Luza, Sandra, Mancuso, Serafino G., Kang, Dali, Opazo, Carlos M., Mostaid, Md. Shaki, Cropley, Vanessa, McGorry, Patrick, Shannon Weickert, Cynthia, Pantelis, Christos, Bush, Ashley I., Everall, Ian P.

“…Dysregulation of the ubiquitin proteasome system (UPS) has been linked to schizophrenia but it is not clear if this dysregulation is detectable in both brain…”
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Phosphorylation of Amyloid Precursor Protein at Threonine 668 Is Essential for Its Copper-responsive Trafficking in SH-SY5Y Neuroblastoma Cells by Acevedo, Karla M., Opazo, Carlos M., Norrish, David, Challis, Leesa M., Li, Qiao-Xin, White, Anthony R., Bush, Ashley I., Camakaris, James

“…Amyloid precursor protein (APP) undergoes post-translational modification, including O- and N-glycosylation, ubiquitination, and phosphorylation as it traffics…”
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Blood and brain protein levels of ubiquitin-conjugating enzyme E2K (UBE2K) are elevated in individuals with schizophrenia by Meiklejohn, Hannah, Mostaid, Md Shaki, Luza, Sandra, Mancuso, Serafino G., Kang, Dali, Atherton, Sonny, Rothmond, Debora A., Weickert, Cynthia Shannon, Opazo, Carlos M., Pantelis, Christos, Bush, Ashley I., Everall, Ian P., Bousman, Chad A.

“…A number of recent studies have suggested the ubiquitin proteasome system (UPS) in schizophrenia is dysfunctional. The purpose of this study was to investigate…”
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The pathophysiology of axonal transport in Alzheimer's disease by Vicario-Orri, Elena, Opazo, Carlos M, Muñoz, Francisco J

“…Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of…”
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In Vivo 7-Tesla MRI Investigation of Brain Iron and Its Metabolic Correlates in Chronic Schizophrenia by Ravanfar, Parsa, Syeda, Warda T., Jayaram, Mahesh, Rushmore, R. Jarrett, Moffat, Bradford, Lin, Alexander P., Lyall, Amanda E., Merritt, Antonia H., Yaghmaie, Negin, Laskaris, Liliana, Luza, Sandra, Opazo, Carlos M., Liberg, Benny, Chakravarty, M. Mallar, Devenyi, Gabriel A., Desmond, Patricia, Cropley, Vanessa L., Makris, Nikos, Shenton, Martha E., Bush, Ashley I., Velakoulis, Dennis, Pantelis, Christos

“…Brain iron is central to dopaminergic neurotransmission, a key component in schizophrenia pathology. Iron can also generate oxidative stress, which is one…”
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Extracellular [alpha]-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane by Pacheco, Carla R, Morales, Camila N, Ramirez, Alejandra E, Munoz, Francisco J, Gallegos, Scarlet S, Caviedes, Pablo A, Aguayo, Luis G, Opazo, Carlos M

“…It has been postulated that the accumulation of extracellular [alpha]-synuclein ([alpha]-syn) might alter the neuronal membrane by formation of 'pore-like…”
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Nitro-Oxidative Stress after Neuronal Ischemia Induces Protein Nitrotyrosination and Cell Death by Bosch-Morató, Mònica, Guix, Francesc X., Ramos-Fernández, Eva, Palomer, Ernest, ILL-Raga, Gerard, Tajes, Marta, Guivernau, Biuse, Jiménez-Conde, Jordi, Ois, Angel, Pérez-Asensio, Fernando, Reyes-Navarro, Mario, Caballo, Carolina, Galán, Ana M., Alameda, Francesc, Escolar, Ginés, Opazo, Carlos, Planas, Anna, Roquer, Jaume, Valverde, Miguel A., Muñoz, Francisco J.

“…Ischemic stroke is an acute vascular event that obstructs blood supply to the brain, producing irreversible damage that affects neurons but also glial and…”
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Vitamin E but not 17B-estradiol protect against vascular toxicity induced by B-amyloid wild type and the Dutch amyploid variant by Muñoz López, Francisco José, 1964, Opazo, Carlos M, Gil Gómez, Gabriel, Tapia, Gladys, Fernández, Virginia, Valverde, M. A. (Miguel Ángel), 1963, Inestrosa, Nibaldo C

“…Amyloid β-peptide (Aβ) fibril deposition on cerebral vessels produces cerebral amyloid angiopathy that appears in the majority of Alzheimer's disease patients…”
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Stable complexes involving acetylcholinesterase and amyloid-ß-peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils by Álvarez, Alejandra R, Alarcón Martínez, Rodrigo, Opazo, Carlos M, Campos, Eliseo O, Muñoz López, Francisco José, 1964, Calderón, Frances H, Dajas, Federico, Gentry, Mary K, Doctor, Bhupendra P, Mello, Fernando G. de, Inestrosa, Nibaldo C

“…Brain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (Abeta) during its assembly into filaments, in agreement with its…”
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