Search Results - "Opanashuk, Lisa"

Deletion or activation of the aryl hydrocarbon receptor alters adult hippocampal neurogenesis and contextual fear memory by Latchney, Sarah E., Hein, Amy M., O'Banion, M. Kerry, DiCicco‐Bloom, Emanuel, Opanashuk, Lisa A.

“…The aryl hydrocarbon receptor (AhR) is a ligand‐activated transcription factor that mediates the toxicity of dioxin and serves multiple developmental roles. In…”
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The aryl hydrocarbon receptor contributes to the proliferation of human medulloblastoma cells by Dever, Daniel P, Opanashuk, Lisa A

“…The aryl hydrocarbon receptor (AhR), a ligand-activated member of the basic helix-loop-helix (bHLH)/PER-ARNT-SIM (PAS) transcription superfamily, is known to…”
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Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis by Dever, Daniel P., Adham, Zachariah O., Thompson, Bryan, Genestine, Matthieu, Cherry, Jonathan, Olschowka, John A., DiCicco‐Bloom, Emanuel, Opanashuk, Lisa A.

“…ABSTRACT The aryl hydrocarbon receptor (AhR) is a ligand‐activated member of the basic‐helix‐loop‐helix/PER‐ARNT‐SIM(PAS) transcription factor superfamily that…”
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Characterization of binge-dosed methamphetamine-induced neurotoxicity and neuroinflammation by McConnell, Sarah E.A., O’Banion, M. Kerry, Cory-Slechta, Deborah A., Olschowka, John A., Opanashuk, Lisa A.

“…•Higher doses of MA rapidly decreased striatal DA.•Higher doses of MA rapidly and non-persistently decreased striatal TH and DAT.•A wide range of doses of MA…”
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The aryl hydrocarbon receptor has a normal function in the regulation of hematopoietic and other stem/progenitor cell populations by Singh, Kameshwar P., Casado, Fanny L., Opanashuk, Lisa A., Gasiewicz, Thomas A.

“…The aryl hydrocarbon receptor (AhR) is known mainly as the mediator for the toxicity of certain xenobiotics. However, there is also much information to…”
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A clinically relevant dose of cyclophosphamide chemotherapy impairs memory performance on the delayed spatial alternation task that is sustained over time as mice age by Janelsins, Michelle C., Heckler, Charles E., Thompson, Bryan D., Gross, Robert A., Opanashuk, Lisa A., Cory-Slechta, Deborah A.

“…•This study utilizes a chemotherapy model with clinically relevant features.•Delayed spatial alternation detects subtle memory effects of cyclophosphamide…”
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Turn Nucleation Perturbs Amyloid β Self-Assembly and Cytotoxicity by Doran, Todd M., Anderson, Elizabeth A., Latchney, Sarah E., Opanashuk, Lisa A., Nilsson, Bradley L.

“…The accumulation of senile plaques composed of amyloid β (Aβ) fibrils is a hallmark of Alzheimer's disease, although prefibrillar oligomeric species are…”
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The effects of postnatal exposure to low-dose bisphenol-A on activity-dependent plasticity in the mouse sensory cortex by Kelly, Emily A, Opanashuk, Lisa A, Majewska, Ania K

“…Bisphenol-A (BPA) is a monomer used in the production of polycarbonate plastics, epoxies and resins and is present in many common household objects ranging…”
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2,3,7,8-Tetracholorodibenzo-p-Dioxin Exposure Disrupts Granule Neuron Precursor Maturation in the Developing Mouse Cerebellum by Collins, Loretta L., Williamson, Mary A., Thompson, Bryan D., Dever, Daniel P., Gasiewicz, Thomas A., Opanashuk, Lisa A.

“…The widespread environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been linked to developmental neurotoxicity associated with abnormal…”
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Subchronic Polychlorinated Biphenyl (Aroclor 1254) Exposure Produces Oxidative Damage and Neuronal Death of Ventral Midbrain Dopaminergic Systems by Lee, Donna W., Notter, Sarah A., Thiruchelvam, Mona, Dever, Daniel P., Fitzpatrick, Richard, Kostyniak, Paul J., Cory-Slechta, Deborah A., Opanashuk, Lisa A.

“…Recent epidemiologic studies have demonstrated a link between organochlorine and pesticide exposure to an enhanced risk for neurodegenerative disorders such as…”
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IGF-1 Partially Restores Chemotherapy-Induced Reductions in Neural Cell Proliferation in Adult C57BL/6 Mice by Janelsins, Michelle C., Roscoe, Joseph A., Berg, Michel J., Thompson, Bryan D., Gallagher, Mark J., Morrow, Gary R., Heckler, Charles E., Jean-Pierre, Pascal, Opanashuk, Lisa A., Gross, Robert A.

“…ABSTRACT Chemotherapeutic agents produce persistent difficulties in memory through an unknown mechanism. We tested the hypothesis that chemotherapeutic agents…”
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Aryl Hydrocarbon Receptor Expression and Activity in Cerebellar Granule Neuroblasts: Implications for Development and Dioxin Neurotoxicity by Williamson, Mary A., Gasiewicz, Thomas A., Opanashuk, Lisa A.

“…2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent teratogen that produces neurobehavioral abnormalities associated with both cognitive and locomotor…”
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Neural precursor cell proliferation is disrupted through activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin by Latchney, Sarah E, Lioy, Daniel T, Henry, Ellen C, Gasiewicz, Thomas A, Strathmann, Frederick G, Mayer-Pröschel, Margot, Opanashuk, Lisa A

“…Neurogenesis involves the proliferation of multipotent neuroepithelial stem cells followed by differentiation into lineage-restricted neural precursor cells…”
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An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly by Doran, Todd M, Anderson, Elizabeth A, Latchney, Sarah E, Opanashuk, Lisa A, Nilsson, Bradley L

“…Amyloid-β (Aβ) self-assembly into cross-β amyloid fibrils is implicated in a causative role in Alzheimer’s disease pathology. Uncertainties persist regarding…”
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Modulation of Antioxidant Defense Systems by the Environmental Pesticide Maneb in Dopaminergic Cells by Barlow, Brian K., Lee, Donna W., Cory-Slechta, Deborah A., Opanashuk, Lisa A.

“…A lack of evidence supporting a role of heritability in the development of idiopathic Parkinson’s disease (PD) has implicated exposures to environmental…”
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Heme-Oxygenase-1 Promotes Polychlorinated Biphenyl Mixture Aroclor 1254-Induced Oxidative Stress and Dopaminergic Cell Injury by Lee, Donna W., Gelein, Robert M., Opanashuk, Lisa A.

“…Dopaminergic (DAergic) systems have been identified as putative targets for polycholorinated biphenyl (PCB) actions. However, the precise mechanisms leading to…”
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Presence and Functional Activity of the Aryl Hydrocarbon Receptor in Isolated Murine Cerebral Vascular Endothelial Cells and Astrocytes by Filbrandt, Carissa R., Wu, Zhenhua, Zlokovic, Berislav, Opanashuk, Lisa, Gasiewicz, Thomas A.

“…Numerous functions regulated by the central nervous system (CNS) are targeted by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); however, the cell specific targets…”
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Correction to An Azobenzene Photoswitch Sheds Light on Turn Nucleation in Amyloid-β Self-Assembly by Doran, Todd M, Anderson, Elizabeth A, Latchney, Sarah E, Opanashuk, Lisa A, Nilsson, Bradley L

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2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions by LoPachin, Richard M, He, Deke, Reid, Maria L, Opanashuk, Lisa A

“…Quantitative morphometric analyses have demonstrated that axon atrophy is the primary neuropathic feature in the CNS and PNS of rats intoxicated with…”
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Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Hippocampus: Modulation of Expression by Seizures and Anti-Excitotoxic Action by Opanashuk, Lisa A, Mark, Robert J, Porter, Julie, Damm, Deborah, Mattson, Mark P, Seroogy, Kim B

“…The expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF), an EGF receptor ligand, was investigated in rat forebrain under basal…”
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