Search Results - "Ooijevaar‐de Heer, Pleuni"

Cross-reactivity of IgM anti-modified protein antibodies in rheumatoid arthritis despite limited mutational load by Reijm, Sanne, Kissel, Theresa, Stoeken-Rijsbergen, Gerrie, Slot, Linda M, Wortel, Corrie M, van Dooren, Hugo J, Levarht, Nivine E. W, Kampstra, Arieke S. B, Derksen, Veerle F. A. M, Heer, Pleuni Ooijevaar-de, Bang, Holger, Drijfhout, Jan W, Trouw, Leendert A, Huizinga, Tom W. J, Rispens, Theo, Scherer, Hans U, Toes, René E. M

“…Abstract Background Anti-modified protein antibodies (AMPA) targeting citrullinated, acetylated and/or carbamylated self-antigens are hallmarks of rheumatoid…”
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Structural Determinants of Unique Properties of Human IgG4-Fc by Davies, Anna M., Rispens, Theo, Ooijevaar-de Heer, Pleuni, Gould, Hannah J., Jefferis, Roy, Aalberse, Rob C., Sutton, Brian J.

“…Human IgG4, normally the least abundant of the four subclasses of IgG in serum, displays a number of unique biological properties. It can undergo heavy-chain…”
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Dynamics of circulating TNF during adalimumab treatment using a drug-tolerant TNF assay by Berkhout, Lea C, l'Ami, Merel J, Ruwaard, Jill, Hart, Margreet H, Heer, Pleuni Ooijevaar-de, Bloem, Karien, Nurmohamed, Michael T, van Vollenhoven, Ronald F, Boers, Maarten, Alvarez, Daniel F, Smith, Catherine H, Wolbink, Gerrit J, Rispens, Theo

“…Patients with rheumatoid arthritis (RA) can be successfully treated with tumor necrosis factor (TNF) inhibitors, including the monoclonal antibody adalimumab…”
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Identification of Clinically and Pathophysiologically Relevant Rheumatoid Factor Epitopes by Engineered IgG Targets by Falkenburg, Willem J. J., Oskam, Nienke, Koers, Jana, Boheemen, Laurette, Ooijevaar‐de Heer, Pleuni, Verstappen, Gwenny M., Bootsma, Hendrika, Kroese, Frans G. M., Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…Objective Rheumatoid factors (RFs), which are anti‐IgG autoantibodies strongly associated with rheumatoid arthritis (RA), are also found in other diseases and…”
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Novel approach to monitor intravenous immunoglobulin pharmacokinetics in humans using polymorphic determinants in IgG1 constant domains by Tilburg, Sander J., Jacobs, Bart C., Ooijevaar‐de Heer, Pleuni, Fokkink, Willem‐Jan R., Huizinga, Ruth, Vidarsson, Gestur, Rispens, Theo

“…Clinical efficacy of intravenous immunoglobulin treatment (IVIg) is related to its pharmacokinetic (PK) profile. Its usual evaluation, by measuring serum total…”
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Human IgE does not bind to human FcRn by Brinkhaus, Maximilian, van der Kooi, Elvera J., Bentlage, Arthur E. H., Ooijevaar-de Heer, Pleuni, Derksen, Ninotska I. L., Rispens, Theo, Vidarsson, Gestur

“…The neonatal Fc receptor (FcRn) is known to mediate placental transfer of IgG from mother to unborn. IgE is widely known for triggering immune responses to…”
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Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation by Falkenburg, Willem J J, Kempers, Ayla C, Dekkers, Gillian, Ooijevaar-de Heer, Pleuni, Bentlage, Arthur E H, Vidarsson, Gestur, van Schaardenburg, Dirkjan, Toes, René E M, Scherer, Hans U, Rispens, Theo

“…Recent reports describe interactions between the two most prominent RA-related autoantibodies, RFs and ACPAs. The main aim of the present study was to…”
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Dynamics of antibodies to SARS‐CoV‐2 in convalescent plasma donors by Steenhuis, Maurice, Mierlo, Gerard, Derksen, Ninotska IL, Ooijevaar‐de Heer, Pleuni, Kruithof, Simone, Loeff, Floris L, Berkhout, Lea C, Linty, Federica, Reusken, Chantal, Reimerink, Johan, Hogema, Boris, Zaaijer, Hans, Watering, Leo, Swaneveld, Francis, Gils, Marit J, Bosch, Berend Jan, Ham, S Marieke, Brinke, Anja, Vidarsson, Gestur, Schoot, Ellen C, Rispens, Theo

“…Objectives Characterisation of the human antibody response to SARS‐CoV‐2 infection is vital for serosurveillance purposes and for treatment options such as…”
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Nanomolar to sub-picomolar affinity measurements of antibody–antigen interactions and protein multimerizations: Fluorescence-assisted high-performance liquid chromatography by Rispens, Theo, Heer, Pleuni Ooijevaar-de, Derksen, Ninotska I.L., Wolbink, Gertjan, van Schouwenburg, Pauline A., Kruithof, Simone, Aalberse, Rob C.

“…Although several techniques exist for the measurement of high-affinity interactions, it is still challenging to determine dissociation constants around or even…”
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Adaptive antibody diversification through N-linked glycosylation of the immunoglobulin variable region by van de Bovenkamp, Fleur S., Derksen, Ninotska I. L., Heer, Pleuni Ooijevaar-de, van Schie, Karin A., Kruithof, Simone, Berkowska, Magdalena A., van der Schoot, C. Ellen, IJspeert, Hanna, van der Burg, Mirjam, Gils, Ann, Hafkenscheid, Lise, Toes, René E. M., Rombouts, Yoann, Plomp, Rosina, Wuhrer, Manfred, van Ham, S. Marieke, Vidarsson, Gestur, Rispens, Theo

“…A hallmark of B-cell immunity is the generation of a diverse repertoire of antibodies from a limited set of germline V(D)J genes. This repertoire is usually…”
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Rheumatoid factor autoantibody repertoire profiling reveals distinct binding epitopes in health and autoimmunity by Oskam, Nienke, Ooijevaar-De Heer, Pleuni, Kos, Dorien, Jeremiasse, Jorn, van Boheemen, Laurette, Verstappen, Gwenny M, Kroese, Frans G M, van Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…Rheumatoid factors (RF) are one of the hallmark autoantibodies characteristic of rheumatoid arthritis (RA), and are frequently observed in other diseases and…”
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Mechanism of Immunoglobulin G4 Fab-arm Exchange by Rispens, Theo, Ooijevaar-de Heer, Pleuni, Bende, Onno, Aalberse, Rob C

“…Immunoglobulin G (IgG) antibodies are symmetrical molecules that may be regarded as covalent dimers of 2 half-molecules, each consisting of a light chain and a…”
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Factors affecting IgG4-mediated complement activation by Oskam, Nienke, Damelang, Timon, Streutker, Marij, Ooijevaar-de Heer, Pleuni, Nouta, Jan, Koeleman, Carolien, Van Coillie, Julie, Wuhrer, Manfred, Vidarsson, Gestur, Rispens, Theo

“…Of the four human immunoglobulin G (IgG) subclasses, IgG4 is considered the least inflammatory, in part because it poorly activates the complement system…”
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IgG Subclass Specificity Discriminates Restricted IgM Rheumatoid Factor Responses From More Mature Anti–Citrullinated Protein Antibody–Associated or Isotype‐Switched IgA Responses by Falkenburg, Willem J. J., van Schaardenburg, Dirkjan, Ooijevaar‐de Heer, Pleuni, Wolbink, Gertjan, Rispens, Theo

“…Objective To investigate the presence and patterns of specific IgG subclass recognition by IgM rheumatoid factor (IgM‐RF) and IgA‐RF with a newly developed…”
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Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange by Rispens, Theo, Davies, Anna M., Ooijevaar-de Heer, Pleuni, Absalah, Samira, Bende, Onno, Sutton, Brian J., Vidarsson, Gestur, Aalberse, Rob C.

“…Interdomain interactions between the CH3 domains of antibody heavy chains are the first step in antibody assembly and are of prime importance for maintaining…”
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CD5L is a canonical component of circulatory IgM by Oskam, Nienke, den Boer, Maurits A, Lukassen, Marie V, Ooijevaar-de Heer, Pleuni, Veth, Tim S, van Mierlo, Gerard, Lai, Szu-Hsueh, Derksen, Ninotska I L, Yin, Victor, Streutker, Marij, Franc, Vojtech, Šiborová, Marta, Damen, Mirjam J A, Kos, Dorien, Barendregt, Arjan, Bondt, Albert, van Goudoever, Johannes B, de Haas, Carla J C, Aerts, Piet C, Muts, Remy M, Rooijakkers, Suzan H M, Vidarsson, Gestur, Rispens, Theo, Heck, Albert J R

“…Immunoglobulin M (IgM) is an evolutionary conserved key component of humoral immunity, and the first antibody isotype to emerge during an immune response. IgM…”
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Variable Domain N -Linked Glycans Acquired During Antigen-Specific Immune Responses Can Contribute to Immunoglobulin G Antibody Stability by van de Bovenkamp, Fleur S, Derksen, Ninotska I L, van Breemen, Mariëlle J, de Taeye, Steven W, Ooijevaar-de Heer, Pleuni, Sanders, Rogier W, Rispens, Theo

“…Immunoglobulin G (IgG) can contain -linked glycans in the variable domains, the so-called Fab glycans, in addition to the Fc glycans in the C 2 domains. These…”
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Next-generation rheumatoid factor assay provides improved predictive power for the development of arthritis in patients at risk by Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Kos, Dorien, van Boheemen, Laurette, van Schaardenburg, Dirkjan, Wolbink, Gertjan, Rispens, Theo

“…ObjectiveRheumatoid arthritis (RA) is characterised by the presence of autoantibodies, among which those targeting the constant region of immunoglobulin G…”
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Infusion reactions during infliximab treatment are not associated with IgE anti-infliximab antibodies by van Schie, Karin A, Ooijevaar-De Heer, Pleuni, Kruithof, Simone, Plasencia, Chamaida, Jurado, Teresa, Pascual Salcedo, Dora, Brandse, Johannan F, d'Haens, Geert Ram, Wolbink, Gerrit Jan, Rispens, Theo

“…Controversy exists on the role of IgE antidrug antibodies (IgE-ADA) in infusion reactions (IR) on infliximab treatment, partly due to the lack of a positive…”
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Longitudinal rheumatoid factor autoantibody responses after SARS-CoV-2 vaccination or infection by Keijzer, Sofie, Oskam, Nienke, Ooijevaar-de Heer, Pleuni, Steenhuis, Maurice, Keijser, Jim B D, Wieske, Luuk, van Dam, Koos P J, Stalman, Eileen W, Kummer, Laura Y L, Boekel, Laura, Kuijpers, Taco W, Ten Brinke, Anja, van Ham, S Marieke, Eftimov, Filip, Tas, Sander W, Wolbink, Gerrit J, Rispens, Theo

“…Rheumatoid factors (RFs) are autoantibodies that target the Fc region of IgG, and are found in patients with rheumatic diseases as well as in the healthy…”
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