Search Results - "Ooijen, Henk van"

A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer by Canté-Barrett, Kirsten, Holtzer, Laurent, van Ooijen, Henk, Hagelaar, Rico, Cordo’, Valentina, Verhaegh, Wim, van de Stolpe, Anja, Meijerink, Jules P. P.

“…Background: The Notch signal transduction pathway is pivotal for various physiological processes, including immune responses, and has been implicated in the…”
Get full text

Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types by van de Stolpe, Anja, Holtzer, Laurent, van Ooijen, Henk, Inda, Marcia Alves de, Verhaegh, Wim

“…Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g., in cancer…”
Get full text

Assessment of Functional Phosphatidylinositol 3-Kinase Pathway Activity in Cancer Tissue Using Forkhead Box-O Target Gene Expression in a Knowledge-Based Computational Model by van Ooijen, Henk, Hornsveld, Marten, Dam-de Veen, Christa, Velter, Rick, Dou, Meng, Verhaegh, Wim, Burgering, Boudewijn, van de Stolpe, Anja

“…The phosphatidylinositol 3-kinase (PI3K) pathway is commonly activated in cancer. Tumors are potentially sensitive to PI3K pathway inhibitors, but reliable…”
Get full text

Publisher Correction: Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types by van de Stolpe, Anja, Holtzer, Laurent, van Ooijen, Henk, Inda, Marcia Alves de, Verhaegh, Wim

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
Get full text

Abstract P5-02-08: Androgen receptor pathway activity and the ratio between androgen and estrogen receptor pathway activity in breast cancer subtypes by van de Stolpe, Anja, Wesseling-Rozendaal, Yvonne, de Inda, Marcia Alves, van Ooijen, Henk, Verhaegh, Wim

“…Abstract Background: Androgen receptor (AR) immunohistochemistry staining in breast cancer has revealed frequent AR expression in all breast cancer subtypes…”
Get full text

Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways by VERHAEGH, Wim, VAN OOIJEN, Henk, VAN DE STOLPE, Anja, INDA, Márcia A, HATZIS, Pantelis, VERSTEEG, Rogier, SMID, Marcel, MARTENS, John, FOEKENS, John, VAN DE WIEL, Paul, CLEVERS, Hans

“…Increasing knowledge about signal transduction pathways as drivers of cancer growth has elicited the development of "targeted drugs," which inhibit aberrant…”
Get full text

Abstract 2645: Quantitative measurement of multiple signal transduction pathway activities in cell and tissue culture, including cancer, fibroblast, and immune cell types by Stolpe, Anja Van De, Inda, Marcia Alves de, Biezen-Timmermans, Eveline den, Holtzer, Laurent, Ooijen, Henk van, Verhaegh, Wim

“…Abstract To improve pathophysiology research, biomarker discovery and drug development, cell culture models should adequately mimic human (patho)physiology and…”
Get full text

A Test to Quantify NOTCH Pathway Activity in T Cell Acute Lymphoblastic Leukemia Patients by Canté-Barrett, Kirsten, Holtzer, Laurent, van Ooijen, Henk, Hagelaar, Rico, Cordo', Valentina, Verhaegh, Wim, van de Stolpe, Anja, Meijerink, Jules P.P.

“…Background The NOTCH signaling pathway is pivotal for various physiological processes including immune responses, and has been implicated in the pathogenesis…”
Get full text

Abstract 4261: Development of quantitative multi-platform tests for easy readout of AR, ER, PI3K and MAPK pathway activity to unravel pathophysiology across cancer and tissue types by Akse, Martijn, van Ooijen, Henk, Pierik, Anke, van den Bosch, Sandra, van Zon, Hans, Holtzer, Laurent, van Brussel, Anne, Inda, Márcia, Wesseling-Rozendaal, Yvonne, Verhaegh, Wim, den Biezen-Timmermans, Eveline

“…Abstract Introduction: Currently, the selection of targeted therapy is commonly based on genetic data, such as well-known gene mutations, but these mutations…”
Get full text

Abstract 2656: Estrogen receptor pathway activity in endometrial carcinomas and its relation to tumor grade and recurrence by Putten, Louis J. van der, Brussel, Anne van, Weelden, Willem Jan van, Inda, Márcia A. de, Massuger, Leon F., Ooijen, Henk van, Stolpe, Anja van de, Pijnenborg, Johanna M.

“…Abstract Background Immunohistochemical (IHC) loss of expression of the estrogen (ER) and progesterone receptor (PR) from endometrial carcinomas is associated…”
Get full text

ER and PI3K Pathway Activity in Primary ER Positive Breast Cancer Is Associated with Progression-Free Survival of Metastatic Patients under First-Line Tamoxifen by Sieuwerts, Anieta M, Inda, Márcia A, Smid, Marcel, van Ooijen, Henk, van de Stolpe, Anja, Martens, John W M, Verhaegh, Wim F J

“…Estrogen receptor positive (ER+) breast cancer patients are eligible for hormonal treatment, but only around half respond. A test with higher specificity for…”
Get full text

Abstract 5291: Prognosis within different breast cancer subtypes using functional activity of signaling pathways by van Ooijen, Henk, Inda, Márcia A., Hoffmann, Ralf, van de Wiel, Paul, van de Stolpe, Anja, Verhaegh, Wim

“…Abstract Introduction Gene signatures to assess prognosis of breast cancer patients are generally restricted to ER-positive/luminal breast cancers, and provide…”
Get full text

Optimal risk estimation for thrombosis based on coagulation protein concentrations by Bakker, Bart, Van Den Ham, Rene, Van Ooijen, Henk

“…Results The machine learning methods based on the complete set of inputs (including genetic effects and coagulation protein concentrations) outperformed the…”
Get full text

Abstract 59: Identifying tumor driving signaling pathways for companion diagnostics using computational pathway models by Verhaegh, Wim, van Ooijen, Henk, Alves de Inda, Marcia, Dulla, Kalyan, Hoffmann, Ralf, van Strijp, Dianne, Hatzis, Pantelis, Clevers, Hans, van de Stolpe, Anja

“…Abstract Introduction Targeted drug treatment requires reliable companion diagnostics for therapy selection. Genomic and transcriptomic data can provide input…”
Get full text