Search Results - "Ooi, London"

MicroRNA‐216a/217‐induced epithelial‐mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer by Xia, Hongping, Ooi, London Lucien P.J., Hui, Kam M.

“…Tumor recurrence and metastases are the major obstacles to improving the prognosis of patients with hepatocellular carcinoma (HCC). To identify novel risk…”
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Interaction between tumour-infiltrating B cells and T cells controls the progression of hepatocellular carcinoma by Garnelo, Marta, Tan, Alex, Her, Zhisheng, Yeong, Joe, Lim, Chun Jye, Chen, Jinmiao, Lim, Kiat Hon, Weber, Achim, Chow, Pierce, Chung, Alexander, Ooi, London Lucien Pj, Toh, Han Chong, Heikenwalder, Mathias, Ng, Irene O L, Nardin, Alessandra, Chen, Qingfeng, Abastado, Jean-Pierre, Chew, Valerie

“…The nature of the tumour-infiltrating leucocytes (TILs) is known to impact clinical outcome in carcinomas, including hepatocellular carcinoma (HCC). However,…”
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Microvascular Invasion Is a Better Predictor of Tumor Recurrence and Overall Survival Following Surgical Resection for Hepatocellular Carcinoma Compared to the Milan Criteria by LIM, Kheng-Choon, CHOW, Pierce Kah-Hoe, ALLEN, John C, CHIA, Ghim-Song, LIM, Miaoshan, CHEOW, Peng-Chung, CHUNG, Alexander Y. F, OOI, London L. P, TAN, Say-Beng

“…To compare microvascular invasion (McVI) with parameters defined by the Milan criteria in predicting tumor recurrence and overall survival (OS) in patients…”
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Profiling MicroRNA Expression in Hepatocellular Carcinoma Reveals MicroRNA-224 Up-regulation and Apoptosis Inhibitor-5 as a MicroRNA-224-specific Target by Wang, Yu, Lee, Alvin T.C., Ma, Joel Z.I., Wang, Jingbo, Ren, Jianwei, Yang, Yuchen, Tantoso, Erwin, Li, Kuo-Bin, Ooi, London L. P. J, Tan, Patrick, Lee, Caroline G.L.

“…Like other cancers, aberrant gene regulation features significantly in hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) were recently found to regulate gene…”
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EDIL3 is a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma by Xia, Hongping, Chen, Jianxiang, Shi, Ming, Gao, Hengjun, Sekar, Karthik, Seshachalam, Veerabrahma Pratap, Ooi, London Lucien P.J, Hui, Kam M

“…Graphical abstract…”
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Upregulation of Rac GTPase-Activating Protein 1 Is Significantly Associated with the Early Recurrence of Human Hepatocellular Carcinoma by WANG, Suk Mei, OOI, London Lucien P. J, HUI, Kam M

“…To assess the significance of Rac GTPase-activating protein 1 (RACGAP1) expression in identifying HBV-positive human hepatocellular carcinoma (HCC) patients…”
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Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinoma by Chew, Valerie, Chen, Jinmiao, Lee, Deming, Loh, Evelyn, Lee, Joyce, Lim, Kiat Hon, Weber, Achim, Slankamenac, Ksenija, Poon, Ronnie T P, Yang, Henry, Ooi, London Lucien P J, Toh, Han Chong, Heikenwalder, Mathias, Ng, Irene O L, Nardin, Alessandra, Abastado, Jean-Pierre

“…Hepatocellular carcinoma (HCC) is a heterogeneous disease with poor prognosis and limited methods for predicting patient survival. The nature of the immune…”
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MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma by Xia, Hongping, Ooi, London Lucien P J, Hui, Kam M

“…The down-regulation of miR-214 has previously been observed in human hepatocellular carcinoma (HCC). Here, we demonstrated the down-regulation of miR-214 is…”
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Circulating microRNAs as Potential Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma by Jin, Yu, Wong, Ye Shen, Goh, Brian K. P., Chan, Chung Yip, Cheow, Peng Chung, Chow, Pierce K. H., Lim, Tony K. H., Goh, George B. B., Krishnamoorthy, Thinesh Lee, Kumar, Rajneesh, Ng, Tze Pin, Chong, Samuel S., Tan, Hwee Huang, Chung, Alexander Y. F., Ooi, London Lucien P. J., Chang, Jason P. E., Tan, Chee Kiat, Lee, Caroline G. L.

“…Hepatocellular carcinoma (HCC) is the fifth most common cancer with high mortality, due to late diagnosis and limited treatment options. Blood miRNAs, which…”
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Significance of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and prognostic nutrition index as preoperative predictors of early mortality after liver resection for huge (≥10 cm) hepatocellular carcinoma by Goh, Brian K.P., Kam, Juinn Huar, Lee, Ser-Yee, Chan, Chung-Yip, Allen, John C., Jeyaraj, Premaraj, Cheow, Peng-Chung, Chow, Pierce K.H., Ooi, London L.P.J., Chung, Alexander Y.F.

“…Background This study aimed to determine preoperative predictors of early (<1 year) mortality from disease recurrence after liver resection (LR) for huge (≥10…”
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Identification and Validation of a Novel Gene Signature Associated with the Recurrence of Human Hepatocellular Carcinoma by SUK MEI WANG, OOI, London Lucien P. J, HUI, Kam M

“…Purpose: To improve the clinical management of human hepatocellular carcinoma (HCC) by accurate identification, at diagnosis, of patients at risk of recurrence…”
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Changing trends and outcomes associated with the adoption of minimally invasive hepatectomy: a contemporary single-institution experience with 400 consecutive resections by Goh, Brian K. P., Lee, Ser-Yee, Teo, Jin-Yao, Kam, Juinn-Huar, Jeyaraj, Prema-Raj, Cheow, Peng-Chung, Chow, Pierce K. H., Ooi, London L. P. J., Chung, Alexander Y. F., Chan, Chung-Yip

“…Background Several studies published mainly from pioneers and early adopters have documented the evolution of minimally invasive hepatectomy (MIH). However,…”
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Evaluation of the Fukuoka Consensus Guidelines for intraductal papillary mucinous neoplasms of the pancreas: Results from a systematic review of 1,382 surgically resected patients by Goh, Brian K.P., MBBS, MMed, MSc, FRCS, Lin, Zhimin, MBBS, Tan, Damien M.Y., MBBS, MRCP, Thng, Choon-Hua, MBBS, FRCR, Khor, Christopher J.L., MBBS, FRCP, Lim, Tony K.H., MBBS, FRCPa, Ooi, London L.P.J., MBBS, FRCS, MD, Chung, Alexander Y.F., MBBS, FRCS

“…Background International consensus guidelines to guide management of intraductal papillary mucinous neoplasms (IPMN) were revised in Fukuoka and published in…”
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Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis by Xiang, Yan, Stine, Zachary E, Xia, Jinsong, Lu, Yunqi, O'Connor, Roddy S, Altman, Brian J, Hsieh, Annie L, Gouw, Arvin M, Thomas, Ajit G, Gao, Ping, Sun, Linchong, Song, Libing, Yan, Benedict, Slusher, Barbara S, Zhuo, Jingli, Ooi, London L, Lee, Caroline G L, Mancuso, Anthony, McCallion, Andrew S, Le, Anne, Milone, Michael C, Rayport, Stephen, Felsher, Dean W, Dang, Chi V

“…Glutaminase (GLS), which converts glutamine to glutamate, plays a key role in cancer cell metabolism, growth, and proliferation. GLS is being explored as a…”
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Evaluation of the Sendai and 2012 International Consensus Guidelines based on cross-sectional imaging findings performed for the initial triage of mucinous cystic lesions of the pancreas: a single institution experience with 114 surgically treated patients by Goh, Brian K.P., M.B.B.S., M.Sc., F.R.C.S, Thng, Choon-Hua, M.B.B.S., F.R.C.R, Tan, Damien M.Y., M.B.B.S., M.R.C.P, Low, Albert S.C., M.B.B.S., M.Med., F.R.C.R, Wong, Jen-San, M.B.B.S., M.Sc., F.R.C.S, Cheow, Peng-Chung, M.B.B.S., F.R.C.S, Chow, Pierce K.H., M.B.B.S., F.R.C.S., Ph.D, Chung, Alexander Y.F., M.B.B.S., F.R.C.S, Wong, Wai-Keong, M.B.B.S., F.R.C.S, Ooi, London L.P.J., M.B.B.S., F.R.C.S., M.D

“…Abstract Background The Sendai Consensus Guidelines (SCG) were formulated in 2006 to guide the management of mucinous cystic lesions of the pancreas (CLPs) and…”
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Preoperative Predictors of Early Recurrence After Liver Resection for Multifocal Hepatocellular Carcinoma by Guo, Yuxin, Linn, Yun Le, Koh, Ye Xin, Tan, Ek Khoon, Teo, Jin Yao, Cheow, Peng Chung, Jeyaraj, Prema Raj, Chow, Pierce K. H., Ooi, London L. P. J., Chung, Alexander Y. F., Chan, Chung Yip, Goh, Brian K. P.

“…Background Liver transplantation remains the optimal treatment for multifocal hepatocellular carcinoma (HCC). However, due to resource constrains, other…”
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Factors associated with and outcomes of open conversion after laparoscopic minor hepatectomy: initial experience at a single institution by Goh, Brian K. P., Chan, Chung-Yip, Wong, Jen-San, Lee, Ser-Yee, Lee, Victor T. W., Cheow, Peng-Chung, Chow, Pierce K. H., Ooi, London L. P. J., Chung, Alexander Y. F.

“…Background Laparoscopic liver resection has been increasingly adopted worldwide as a result of the rapid advancement in surgical techniques and equipment. This…”
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Perioperative Outcomes of Laparoscopic Repeat Liver Resection for Recurrent HCC: Comparison with Open Repeat Liver Resection for Recurrent HCC and Laparoscopic Resection for Primary HCC by Goh, Brian K. P., Syn, Nicholas, Teo, Jin-Yao, Guo, Yu-Xin, Lee, Ser-Yee, Cheow, Peng-Chung, Chow, Pierce K. H., Ooi, London L. P. J., Chung, Alexander Y. F., Chan, Chung-Yip

“…Background This study aims to determine the safety and efficacy of laparoscopic repeat liver resection (LRLR) for recurrent hepatocellular carcinoma (rHCC)…”
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A comparison between robotic‐assisted laparoscopic distal pancreatectomy versus laparoscopic distal pancreatectomy by Goh, Brian K. P., Chan, Chung Yip, Soh, Hui‐Ling, Lee, Ser Yee, Cheow, Peng‐Chung, Chow, Pierce K. H., Ooi, London L. P. J., Chung, Alexander Y. F.

“…Background This study aims to compare the early perioperative outcomes of robotic‐assisted laparoscopic distal pancreatectomy (RDP) versus laparoscopic distal…”
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MicroRNA‐224 is up‐regulated in hepatocellular carcinoma through epigenetic mechanisms by Wang, Yu, Toh, Han Chong, Chow, Pierce, Chung, Alexander Y. F., Meyers, David J., Cole, Philip A., Ooi, London L. P. J., Lee, Caroline G. L.

“…ABSTRACT MicroRNA‐224 (miR‐224) is one of the most commonly up‐regulated microRNAs in hepatocellular carcinoma (HCC), which affects crucial cellular processes…”
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