Search Results - "Oo, Ye Htun"

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease by Syn, Wing‐Kin, Htun Oo, Ye, Pereira, Thiago A., Karaca, Gamze F., Jung, Youngmi, Omenetti, Alessia, Witek, Rafal P., Choi, Steve S., Guy, Cynthia D., Fearing, Caitlin M., Teaberry, Vanessa, Pereira, Fausto E.L., Adams, David H., Diehl, Anna Mae

“…Liver inflammation is greater in nonalcoholic steatohepatitis (NASH) than steatosis, suggesting that immune responses contribute to nonalcoholic fatty liver…”
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The Next Frontier of Regulatory T Cells: Promising Immunotherapy for Autoimmune Diseases and Organ Transplantations by Terry, Lauren V, Oo, Ye Htun

“…Regulatory T cells (Tregs) are crucial in maintaining tolerance. Hence, Treg immunotherapy is an attractive therapeutic option in autoimmune diseases and organ…”
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Regulatory T Cell Metabolism in the Hepatic Microenvironment by Wawman, Rebecca Ellen, Bartlett, Helen, Oo, Ye Htun

“…Thymic-derived naturally occurring regulatory T cells (tTreg) are crucial for maintaining peripheral immune homeostasis. They play a crucial role in preventing…”
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Symptomatic portal biliopathy: a single centre experience from the UK by Htun Oo, Ye, Olliff, Simon, Haydon, Geoffrey, Thorburn, Douglas

“…BACKGROUND AND METHODSBiliary obstruction as a consequence of portal biliopathy, because of extrahepatic portal vein occlusion is an uncommon cause of biliary…”
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The Impact of Autoimmune Hepatitis and Its Treatment on Health Utility by Wong, Lin Lee, Fisher, Holly F, Stocken, Deborah D, Rice, Stephen, Khanna, Amardeep, Heneghan, Michael A, Oo, Ye Htun, Mells, George, Kendrick, Stuart, Dyson, Jessica Katharine, Jones, David E. J.

“…Patient reporting suggests that the physical and psychological effects of autoimmune hepatitis (AIH) can be substantial. However, health‐related quality of…”
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Gut-Liver Immune Traffic: Deciphering Immune-Pathogenesis to Underpin Translational Therapy by Bozward, Amber G, Ronca, Vincenzo, Osei-Bordom, Daniel, Oo, Ye Htun

“…The tight relationship between the gut and liver on embryological, anatomical and physiological levels inspired the concept of a gut-liver axis as a central…”
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Regulatory T cells in solid organ transplantation by Atif, Muhammad, Conti, Filomena, Gorochov, Guy, Oo, Ye Htun, Miyara, Makoto

“…The induction of graft tolerance remains the holy grail of transplantation. This is important as chronic allograft dysfunction and the side effects of…”
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Clinical Potential of Regulatory T Cell Therapy in Liver Diseases: An Overview and Current Perspectives by Jeffery, Hannah C, Braitch, Manjit Kaur, Brown, Solomon, Oo, Ye Htun

“…The increasing demand for liver transplantation and the decline in donor organs has highlighted the need for alternative novel therapies to prevent chronic…”
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Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis by Syn, Wing‐Kin, Choi, Steve S., Liaskou, Evaggelia, Karaca, Gamze F., Agboola, Kolade M., Oo, Ye Htun, Mi, Zhiyong, Pereira, Thiago A., Zdanowicz, Marzena, Malladi, Padmini, Chen, Yuping, Moylan, Cynthia, Jung, Youngmi, Bhattacharya, Syamal D., Teaberry, Vanessa, Omenetti, Alessia, Abdelmalek, Manal F., Guy, Cynthia D., Adams, David H., Kuo, Paul C., Michelotti, Gregory A., Whitington, Peter F., Diehl, Anna Mae

“…Nonalcoholic steatohepatitis (NASH) is a leading cause of cirrhosis. Recently, we showed that NASH‐related cirrhosis is associated with Hedgehog (Hh) pathway…”
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Bidirectional Cross-Talk between Biliary Epithelium and Th17 Cells Promotes Local Th17 Expansion and Bile Duct Proliferation in Biliary Liver Diseases by Jeffery, Hannah C, Hunter, Stuart, Humphreys, Elizabeth H, Bhogal, Ricky, Wawman, Rebecca E, Birtwistle, Jane, Atif, Muhammad, Bagnal, Christopher J, Rodriguez Blanco, Giovanny, Richardson, Naomi, Warner, Suz, Dunn, Warwick B, Afford, Simon C, Adams, David H, Oo, Ye Htun

“…There is no effective treatment for autoimmune biliary diseases. Therefore, understanding their immunopathology is crucial. The biliary epithelial cells (BEC),…”
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Vδ2 + T Cells-Two Subsets for the Price of One by Davey, Martin S, Willcox, Carrie R, Hunter, Stuart, Oo, Ye Htun, Willcox, Benjamin E

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Beyond FOXP3: a 20-year journey unravelling human regulatory T-cell heterogeneity by Santosh Nirmala, Samikshya, Kayani, Kayani, Gliwiński, Mateusz, Hu, Yueyuan, Iwaszkiewicz-Grześ, Dorota, Piotrowska-Mieczkowska, Magdalena, Sakowska, Justyna, Tomaszewicz, Martyna, Marín Morales, José Manuel, Lakshmi, Kavitha, Marek-Trzonkowska, Natalia Maria, Trzonkowski, Piotr, Oo, Ye Htun, Fuchs, Anke

“…The initial idea of a distinct group of T-cells responsible for suppressing immune responses was first postulated half a century ago. However, it is only in…”
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Liver homing of clinical grade Tregs after therapeutic infusion in patients with autoimmune hepatitis by Oo, Ye Htun, Ackrill, Susan, Cole, Richard, Jenkins, Lee, Anderson, Philip, Jeffery, Hannah C., Jones, Nicholas, Jeffery, Louisa E., Lutz, Philipp, Wawman, Rebecca E., Athwal, Amrita Kaur, Thompson, Jacqui, Gray, Joanna, Guo, Kathy, Barton, Darren, Hirschfield, Gideon M, Wong, Timothy, Guest, Peter, Adams, David H.

“…Autoimmune hepatitis (AIH) is an immune-mediated disease with no curative treatment. Regulatory T cell (Treg) therapy is potentially curative in AIH given the…”
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Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis by Coombes, Jason D., Choi, Steve S., Swiderska-Syn, Marzena, Manka, Paul, Reid, Danielle T., Palma, Elena, Briones-Orta, Marco A., Xie, Guanhua, Younis, Rasha, Kitamura, Naoto, della Peruta, Marco, Bitencourt, Shanna, Dollé, Laurent, Oo, Ye Htun, Mi, Zhiyong, Kuo, Paul C., Williams, Roger, Chokshi, Shilpa, Canbay, Ali, Claridge, Lee C., Eksteen, Bertus, Diehl, Anna Mae, Syn, Wing-Kin

“…Liver fibrosis develops when hepatic stellate cells (HSC) are activated into collagen-producing myofibroblasts. In non-alcoholic steatohepatitis (NASH), the…”
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Efficacy of rituximab in difficult-to-manage autoimmune hepatitis: Results from the International Autoimmune Hepatitis Group by Than, Nwe Ni, Hodson, James, Schmidt-Martin, Daniel, Taubert, Richard, Wawman, Rebecca E., Botter, Meemee, Gautam, Nishant, Bock, Kilian, Jones, Rebecca, Appanna, Gautham D, Godkin, Andrew, Montano-Loza, Aldo J., Lammert, Frank, Schramm, Christoph, Manns, Michael P., Swain, Mark, Burak, Kelly W., Adams, David H., Hirschfield, Gideon M, Oo, Ye Htun

“…Treatment options remain limited for patients with autoimmune hepatitis (AIH), while there are still concerns over the consequences of long-term corticosteroid…”
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Rapid recovery of cytochrome P450 3A4 after protease inhibitor withdrawal in post–liver transplant patients by Oo, Ye Htun, Mutimer, David J.

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Human intrahepatic ILC2 are IL-13positive amphiregulinpositive and their frequency correlates with model of end stage liver disease score by Jeffery, Hannah C, McDowell, Patrick, Lutz, Philipp, Wawman, Rebecca E, Roberts, Sheree, Bagnall, Chris, Birtwistle, Jane, Adams, David H, Oo, Ye Htun

“…Innate lymphoid cells (ILC) have been implicated in the initiation of inflammation and fibrosis in mice. However, ILC have not been characterized in inflamed…”
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CXCR3-dependent recruitment and CCR6-mediated positioning of Th-17 cells in the inflamed liver by Oo, Ye Htun, Banz, Vanessa, Kavanagh, Dean, Liaskou, Evaggelia, Withers, David R, Humphreys, Elizabeth, Reynolds, Gary M, Lee-Turner, Laura, Kalia, Neena, Hubscher, Stefan G, Klenerman, Paul, Eksteen, Bertus, Adams, David H

“…Background & Aims IL-17 secreting CD4 (Th17) and CD8 (Tc17) T cells have been implicated in immune-mediated liver diseases, but the molecular basis for their…”
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Ex situ Normothermic Split Liver Machine Perfusion: Protocol for Robust Comparative Controls in Liver Function Assessment Suitable for Evaluation of Novel Therapeutic Interventions in the Pre-clinical Setting by Attard, Joseph A, Osei-Bordom, Daniel-Clement, Boteon, Yuri, Wallace, Lorraine, Ronca, Vincenzo, Reynolds, Gary, Perera, M T P R, Oo, Ye Htun, Mergental, Hynek, Mirza, Darius F, Afford, Simon C

“…donor liver machine perfusion is a promising tool to assess organ viability prior to transplantation and platform to investigate novel therapeutic…”
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Type 2 Autoimmune Hepatitis and Nonadherence to Medication Correlate With Premature Birth and Risk of Postpartum Flare by Olsen, Kathryn, Hodson, James, Ronca, Vincenzo, Bozward, Amber G., Hayden, Jennifer, Wootton, Grace, Armstrong, Matthew, Adams, David H., El‐Sherif, Omar, Ferguson, James, Knox, Ellen, Johnston, Tracey, Thompson, Fiona, Oo, Ye Htun

“…Autoimmune hepatitis (AIH) is an immune‐mediated chronic liver disease that affects all ages, including women of childbearing age. Optimal management during…”
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