Search Results - "Oo, Tinmarla F."

An early axonopathy in a hLRRK2(R1441G) transgenic model of Parkinson disease by Tagliaferro, Patricia, Kareva, Tatyana, Oo, Tinmarla F, Yarygina, Olga, Kholodilov, Nikolai, Burke, Robert E

“…Abstract Mutations in the gene for LRRK2 are the most common cause of familial Parkinson's disease (PD) and patients with these mutations manifest clinical…”
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Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration by Kim, Sang Ryong, Chen, Xiqun, Oo, Tinmarla F., Kareva, Tatyana, Yarygina, Olga, Wang, Chuansong, During, Matthew, Kholodilov, Nikolai, Burke, Robert E.

“…Objective: A prevailing concept in neuroscience has been that the adult mammalian central nervous system is incapable of restorative axon regeneration. Recent…”
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Akt suppresses retrograde degeneration of dopaminergic axons by inhibition of macroautophagy by Cheng, Hsiao-Chun, Kim, Sang Ryong, Oo, Tinmarla F, Kareva, Tatyana, Yarygina, Olga, Rzhetskaya, Margarita, Wang, Chuansong, During, Matthew, Talloczy, Zsolt, Tanaka, Keiji, Komatsu, Masaaki, Kobayashi, Kazuto, Okano, Hideyuki, Kholodilov, Nikolai, Burke, Robert E

“…Axon degeneration is a hallmark of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Such degeneration is not a passive event…”
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Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain by Dragich, Joanna M, Kuwajima, Takaaki, Hirose-Ikeda, Megumi, Yoon, Michael S, Eenjes, Evelien, Bosco, Joan R, Fox, Leora M, Lystad, Alf H, Oo, Tinmarla F, Yarygina, Olga, Mita, Tomohiro, Waguri, Satoshi, Ichimura, Yoshinobu, Komatsu, Masaaki, Simonsen, Anne, Burke, Robert E, Mason, Carol A, Yamamoto, Ai

“…The regulation of protein degradation is essential for maintaining the appropriate environment to coordinate complex cell signaling events and to promote…”
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Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling by Kim, Sang Ryong, Ries, Vincent, Cheng, Hsiao-Chun, Kareva, Tatyana, Oo, Tinmarla F, Yu, W. Haung, Duff, Karen, Kholodilov, Nikolai, Burke, Robert E

“…Abstract The mechanisms underlying the chronic neurodegeneration that occurs in Parkinson's disease (PD) are unknown. One emerging hypothesis is that neural…”
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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease by Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M Flint, Burke, Robert E, Li, Chenjian

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that…”
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Brain-derived neurotrophic factor regulates early postnatal developmental cell death of dopamine neurons of the substantia nigra in vivo by Oo, Tinmarla F., Marchionini, Deanna M., Yarygina, Olga, O'Leary, Paul D., Hughes, Richard A., Kholodilov, Nikolai, Burke, Robert E.

“…Brain-derived neurotrophic factor (BDNF) was the first purified molecule identified to directly support the development of mesencephalic dopamine neurons…”
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Distinct Nuclear and Cytoplasmic Localization of Caspase Cleavage Products in Two Models of Induced Apoptotic Death in Dopamine Neurons of the Substantia Nigra by Oo, Tinmarla F., Siman, Robert, Burke, Robert E.

“…An emerging theme in programmed cell death (PCD) of neurons is that the mechanisms involved depend on the cellular context and the death-inducing stimulus. One…”
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JNK2 and JNK3 combined are essential for apoptosis in dopamine neurons of the substantia nigra, but are not required for axon degeneration by Ries, Vincent, Silva, Robert M., Oo, Tinmarla F., Cheng, Hsiao‐Chun, Rzhetskaya, Margarita, Kholodilov, Nikolai, Flavell, Richard A., Kuan, Chia‐Yi, Rakic, Pasko, Burke, Robert E.

“…Activation of c‐jun N‐terminal kinase (JNK) by the mitogen‐activated protein kinase cascade has been shown to play an important role in the death of dopamine…”
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Regulation of the postnatal development of dopamine neurons of the substantia nigra in vivo by Akt/protein kinase B by Ries, Vincent, Cheng, Hsiao-Chun, Baohan, Amy, Kareva, Tatyana, Oo, Tinmarla F, Rzhetskaya, Margarita, Bland, Ross J, During, Matthew J, Kholodilov, Nikolai, Burke, Robert E

“…Following mitosis, specification and migration during embryogenesis, dopamine neurons of the mesencephalon undergo a postnatal naturally occurring cell death…”
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Expression of cyclin‐dependent kinase 5 and its activator p35 in models of induced apoptotic death in neurons of the substantia nigra in vivo by Neystat, Michael, Rzhetskaya, Margarita, Oo, Tinmarla F., Kholodilov, Nikolai, Yarygina, Olga, Wilson, Alexandria, El‐Khodor, Bassem F., Burke, Robert E.

“…Cyclin‐dependent kinase 5 is predominantly expressed in postmitotic neurons and plays a role in neurite elongation during development. It has also been…”
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Mutant LRRK2R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease by Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M Flint, Burke, Robert E, Li, Chenjian

“…Mutations in LRRK2 can cause Parkinson's disease. The authors create a transgenic mouse model of LRRK2 that recapitulates several cardinal features of the…”
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Increased Expression of Rat Synuclein in the Substantia Nigra Pars Compacta Identified by mRNA Differential Display in a Model of Developmental Target Injury by Kholodilov, Nikolai G., Neystat, Michael, Tinmarla, F. Oo, Steven, E. Lo, Larsen, Kristin E., Sulzer, David, Burke, Robert E.

“…: Human α‐synuclein was identified on the basis of proteolytic fragments derived from senile plaques of Alzheimer's disease, and it is the locus of mutations…”
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Activation of Caspase‐3 in Developmental Models of Programmed Cell Death in Neurons of the Substantia Nigra by Jeon, Beom S., Kholodilov, Nikolai G., Oo, Tinmarla F., Kim, Sang‐Yun, Tomaselli, Kevin J., Srinivasan, Anu, Stefanis, Leonidas, Burke, Robert E.

“…: Programmed cell death has been proposed to play a role in the death of neurons in acute and chronic degenerative neurologic disease. There is now evidence…”
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Upregulation of cytosolic branched chain aminotransferase in substantia nigra following developmental striatal target injury by Kholodilov, Nikolai G, Neystat, Michael, Oo, Tinmarla F, Hutson, Susan M, Burke, Robert E

“…We have previously shown that apoptotic cell death can be induced in substantia nigra (SN) by developmental striatal target lesion. In this model, only a…”
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Age and [alpha]-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling by Kim, Sang Ryong, Ries, Vincent, Cheng, Hsiao-Chun, Kareva, Tatyana, Oo, Tinmarla F, Yu, WHaung, Duff, Karen, Kholodilov, Nikolai, Burke, Robert E

“…The mechanisms underlying the chronic neurodegeneration that occurs in Parkinson's disease (PD) are unknown. One emerging hypothesis is that neural systems…”
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Mutant LRRK2 super(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease by Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M Flint, Burke, Robert E, Li, Chenjian

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that…”
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Mutant [LRRK2.sup.R1441G] BAC transgenic mice recapitulate cardinal features of Parkinson's disease by Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M. Flint, Burke, Robert E, Li, Chenjian

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that…”
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Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease by Li, Chenjian, Li, Yanping, Liu, Wencheng, Oo, Tinmarla F, Wang, Lei, Tang, Yi, Jackson-Lewis, Vernice, Zhou, Chun, Geghman, Kindiya, Bogdanov, Mikhail, Przedborski, Serge, Beal, M Flint, Burke, Robert E

“…Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that…”
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Expression of c-fos, c-jun, and c-jun N-terminal kinase (JNK) in a developmental model of induced apoptotic death in neurons of the substantia nigra by OO, T. F, HENCHCLIFFE, C, JAMES, D, BURKE, R. E

“…The transcription factors c-fos and c-jun have been proposed to play a role in the initiation of programmed cell death in neurons. We have shown that…”
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