Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

Study of the Antimalarial Activity of the Leaf Extracts and Fractions of Persea americana and Dacryodes edulis and Their HPLC Analysis

In the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol,...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine Vol. 2021; pp. 1 - 11
Main Authors: Uzor, Philip F., Onyishi, Chukwuebuka K., Omaliko, Adaeze P., Nworgu, Somtochukwu A., Ugwu, Onyemaechi H., Nwodo, Ngozi J.
Format: Journal Article
Language:English
Published: New York Hindawi 2021
Hindawi Limited
Subjects:
Acetic acid
Animal models
Animals
Antimalarial activity
Antimalarial agents
Antiparasitic agents
Dacryodes edulis
Disease
Drug dosages
Ethnomedicine
Ethyl acetate
Flavonoids
Hematology
High-performance liquid chromatography
Malaria
Parasitemia
Persea americana
Phytochemicals
Plant extracts
Saponins
Secondary metabolites
Variance analysis
Nigeria
Africa
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Summary:In the present study, the antimalarial activity of the extracts and fractions of the leaves of Persea americana and Dacryodes edulis as well as their phytochemical compositions were examined. Each of the extracts of the plants was successively fractionated to obtain hexane, ethyl acetate, methanol, and water fractions. The extracts and fractions were tested against Plasmodium berghei in both curative and suppressive antimalarial mouse models. Their major phytochemical composition was studied by the standard chemical tests and HPLC analysis. The extracts and fractions of P. americana and D. edulis demonstrated significant (p<0.05) maximal plasmodial inhibition as 52.16 ± 2.77% and 57.10 ± 1.98%, respectively, and chemosuppression of parasitemia as 64.01 ± 0.08% and 71.99 ± 0.06%, respectively. The major secondary metabolites identified in the plants include alkaloids, flavonoids, and saponins. It was concluded that P. americana and D. edulis possess promising antimalarial activity and they are potential sources of new lead compounds against malaria.
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Academic Editor: Riaz Ullah
ISSN:1741-427X
1741-4288
DOI:10.1155/2021/5218294