Search Results - "Onuchic, José Nelson"

Toward understanding cancer stem cell heterogeneity in the tumor microenvironment by Bocci, Federico, Gearhart-Serna, Larisa, Boareto, Marcelo, Ribeiro, Mariana, Ben-Jacob, Eshel, Devi, Gayathri R., Levine, Herbert, Onuchic, José Nelson, Jolly, Mohit Kumar

“…The epithelial–mesenchymal transition (EMT) and cancer stem cell (CSC) formation are two paramount processes driving tumor progression, therapy resistance, and…”
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Folding Funnels and Frustration in Off-Lattice Minimalist Protein Landscapes by Nymeyer, Hugh, Garcia, Angel E., Onuchic, Jose Nelson

“…A full quantitative understanding of the protein folding problem is now becoming possible with the help of the energy landscape theory and the protein folding…”
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Landscape Approaches for Determining the Ensemble of Folding Transition States: Success and Failure Hinge on the Degree of Frustration by Nymeyer, Hugh, Socci, Nicholas D., Onuchic, Jose Nelson

“…We present a method for determining structural properties of the ensemble of folding transition states from protein simulations. This method relies on…”
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Understanding the Principles of Pattern Formation Driven by Notch Signaling by Integrating Experiments and Theoretical Models by Bocci, Federico, Onuchic, José Nelson, Jolly, Mohit Kumar

“…Notch signaling is an evolutionary conserved cell-cell communication pathway. Besides regulating cell-fate decisions at an individual cell level, Notch…”
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Dynamics of Electron Transfer Pathways in Cytochrome c Oxidase by Tan, Ming-Liang, Balabin, Ilya, Onuchic, José Nelson

“…Cytochrome c oxidase mediates the final step of electron transfer reactions in the respiratory chain, catalyzing the transfer between cytochrome c and the…”
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A Biophysical Model Uncovers the Size Distribution of Migrating Cell Clusters across Cancer Types by Bocci, Federico, Kumar Jolly, Mohit, Onuchic, José Nelson

“…Migration from the primary tumor is a crucial step in the metastatic cascade. Cells with various degrees of adhesion and motility migrate and are launched into…”
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Pressure-Induced Protein-Folding/Unfolding Kinetics by Hillson, Nathan, Onuchic, Jose Nelson, Garcia, Angel E.

“…We use an off-lattice minimalist model to describe the effects of pressure in slowing down the folding/unfolding kinetics of proteins when subjected to…”
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Chemical Physics of Protein Folding by Brooks, Charles L., Gruebele, Martin, Onuchic, Jose Nelson, Wolynes, Peter G.

“…Brooks et al address the new viewpoint of protein folding used by chemical physicists. This view requires a new set of theoretical ideas, computational…”
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Pierced Lasso Topology Controls Function in Leptin by Haglund, Ellinor, Pilko, Anna, Wollman, Roy, Jennings, Patricia Ann, Onuchic, José Nelson

“…Protein engineering is a powerful tool in drug design and therapeutics, where disulphide bridges are commonly introduced to stabilize proteins. However, these…”
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Topological and energetic factors: what determines the structural details of the transition state ensemble and “en-route” intermediates for protein folding? an investigation for small globular proteins by Clementi, Cecilia, Nymeyer, Hugh, Onuchic, José Nelson

“…Recent experimental results suggest that the native fold, or topology, plays a primary role in determining the structure of the transition state ensemble, at…”
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Sergio Mascarenhas a Polymath in Physics by Baffa, Oswaldo, Costa-Filho, Antonio, Crestana, Silvio, Oliva, Glaucius, Onuchic, José Nelson, Rezende, Sergio Machado

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Stretching Lattice Models of Protein Folding by Socci, Nicholas D., Onuchic, Jose Nelson, Wolynes, Peter G.

“…A new class of experiments that probe folding of individual protein domains uses mechanical stretching to cause the transition. We show how stretching forces…”
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Theory of protein folding: the energy landscape perspective by Onuchic, J N, Luthey-Schulten, Z, Wolynes, P G

“…The energy landscape theory of protein folding is a statistical description of a protein's potential surface. It assumes that folding occurs through organizing…”
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Funnels, pathways, and the energy landscape of protein folding: a synthesis by Bryngelson, J D, Onuchic, J N, Socci, N D, Wolynes, P G

“…The understanding, and even the description of protein folding is impeded by the complexity of the process. Much of this complexity can be described and…”
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Pericytes enable effective angiogenesis in the presence of proinflammatory signals by Kang, Tae-Yun, Bocci, Federico, Jolly, Mohit Kumar, Levine, Herbert, Onuchic, José Nelson, Levchenko, Andre

“…Angiogenesis frequently occurs in the context of acute or persistent inflammation. The complex interplay of proinflammatory and proangiogenic cues is only…”
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Protein folding mechanisms and the multidimensional folding funnel by Socci, Nicholas D., Onuchic, José Nelson, Wolynes, Peter G.

“…An important idea that emerges from the energy landscape theory of protein folding is that subtle global features of the protein landscape can profoundly…”
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A Molecular Shift Register Based on Electron Transfer by Hopfield, J. J., Onuchic, José Nelson, Beratan, David N.

“…An electronic shift-register memory at the molecular level is described. The memory elements are based on a chain of electron-transfer molecules and the…”
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Uncovering the molecular mechanisms behind disease-associated leptin variants by Haglund, Ellinor, Nguyen, Lannie, Schafer, Nicholas Peter, Lammert, Heiko, Jennings, Patricia Ann, Onuchic, José Nelson

“…The pleiotropic hormone leptin has a pivotal role in regulating energy balance by inhibiting hunger and increasing energy expenditure. Homozygous mutations…”
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The Pierced Lasso Topology Leptin has a Bolt on Dynamic Domain Composed by the Disordered Loops I and III by Danielsson, Jens, Noel, Jeffrey Kenneth, Simien, Jennifer Michelle, Duggan, Brendan Michael, Oliveberg, Mikael, Onuchic, José Nelson, Jennings, Patricia Ann, Haglund, Ellinor

“…Leptin is an important signaling hormone, mostly known for its role in energy expenditure and satiety. Furthermore, leptin plays a major role in other…”
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Quantitative Characteristic of ncRNA Regulation in Gene Regulatory Networks by Bocci, Federico, Jolly, Mohit Kumar, Levine, Herbert, Onuchic, José Nelson

“…RNA is mostly known for its role in protein synthesis, where it encodes information for protein sequence in its messenger RNA (mRNA) form (translation). Yet,…”
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