Search Results - "Ono, Chiho"

Efficacy and safety of bosutinib versus imatinib for newly diagnosed chronic myeloid leukemia in the Asian subpopulation of the phase 3 BFORE trial by Chuah, Charles, Koh, Liang Piu, Numbenjapon, Tontanai, Zang, Dae Young, Ong, Kiat Hoe, Do, Young Rok, Ohkura, Masayuki, Ono, Chiho, Viqueira, Andrea, Cortes, Jorge E., Brümmendorf, Tim H.

“…Bosutinib is approved in the United States, Europe, Japan, and other countries for treatment of newly diagnosed chronic phase (CP) chronic myeloid leukemia…”
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Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions by Ono, Chiho, Hsyu, Poe-Hirr, Abbas, Richat, Loi, Cho-Ming, Yamazaki, Shinji

“…Bosutinib is an orally available Src/Abl tyrosine kinase inhibitor indicated for the treatment of patients with Philadelphia chromosome-positive chronic…”
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Phase I study of glasdegib (PF‐04449913), an oral smoothened inhibitor, in Japanese patients with select hematologic malignancies by Minami, Yosuke, Minami, Hironobu, Miyamoto, Toshihiro, Yoshimoto, Goichi, Kobayashi, Yukio, Munakata, Wataru, Onishi, Yasushi, Kobayashi, Masahiro, Ikuta, Mari, Chan, Geoffrey, Woolfson, Adrian, Ono, Chiho, Shaik, Mohammed Naveed, Fujii, Yosuke, Zheng, Xianxian, Naoe, Tomoki

“…The hedgehog signaling pathway regulates multiple morphogenetic processes during embryogenesis. Aberrant activation of the hedgehog pathway signal transduction…”
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Bosutinib in Japanese patients with newly diagnosed chronic-phase chronic myeloid leukemia: final 3-year follow-up results of a phase 2 study by Ono, Takaaki, Hino, Masayuki, Matsumura, Itaru, Fujisawa, Shin, Ishizawa, Kenichi, Sakaida, Emiko, Sekiguchi, Naohiro, Ono, Chiho, Aizawa, Mana, Tanetsugu, Yusuke, Koide, Yuichiro, Takahashi, Naoto

“…Bosutinib has been evaluated for treatment of chronic-phase chronic myeloid leukemia (CP-CML) in several clinical studies, including in Japan. This open-label,…”
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Safety profile of bosutinib in Japanese versus non-Japanese patients with chronic myeloid leukemia: a pooled analysis by Takahashi, Naoto, Cortes, Jorge E., Sakaida, Emiko, Ishizawa, Kenichi, Ono, Takaaki, Doki, Noriko, Matsumura, Itaru, García-Gutiérrez, Valentín, Rosti, Gianantonio, Ono, Chiho, Ohkura, Masayuki, Tanetsugu, Yusuke, Viqueira, Andrea, Brümmendorf, Tim H.

“…Bosutinib has been investigated in multiple clinical trials globally, including Japan, for treatment of chronic myeloid leukemia (CML). A pooled analysis of…”
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Phase I study of anti‐CD22 immunoconjugate inotuzumab ozogamicin plus rituximab in relapsed/refractory B‐cell non‐Hodgkin lymphoma by Ogura, Michinori, Hatake, Kiyohiko, Ando, Kiyoshi, Tobinai, Kensei, Tokushige, Kota, Ono, Chiho, Ishibashi, Taro, Vandendries, Erik

“…Inotuzumab ozogamicin (CMC‐544), a humanized anti‐CD22 antibody conjugated to the potent cytotoxic antibiotic calicheamicin, targets the CD22 antigen expressed…”
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Inotuzumab ozogamicin versus standard of care in Asian patients with relapsed/refractory acute lymphoblastic leukemia by Fujishima, Naohito, Uchida, Toshiki, Onishi, Yasushi, Jung, Chul Won, Goh, Yeow Tee, Ando, Kiyoshi, Wang, Ming Chung, Ono, Chiho, Matsumizu, Miyako, Paccagnella, M. Luisa, Sleight, Barbara, Vandendries, Erik, Fujii, Yosuke, Hino, Masayuki

“…Inotuzumab ozogamicin (InO) is a targeted treatment for adults with relapsed or refractory B-cell acute lymphoblastic leukemia (ALL). InO was previously…”
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Phase I study of inotuzumab ozogamicin (CMC‐544) in Japanese patients with follicular lymphoma pretreated with rituximab‐based therapy by Ogura, Michinori, Tobinai, Kensei, Hatake, Kiyohiko, Uchida, Toshiki, Kasai, Masanobu, Oyama, Takashi, Suzuki, Tatsuya, Kobayashi, Yukio, Watanabe, Takashi, Azuma, Teruhisa, Mori, Masakazu, Terui, Yasuhito, Yokoyama, Masahiro, Mishima, Yuko, Takahashi, Shunji, Ono, Chiho, Ohata, Junko

“…Inotuzumab ozogamicin (CMC‐544), an antibody‐targeted chemotherapeutic agent composed of an anti‐CD22 antibody conjugated to calicheamicin, a potent cytotoxic…”
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Long-term treatment with bosutinib in a phase 1/2 study in Japanese chronic myeloid leukemia patients resistant/intolerant to prior tyrosine kinase inhibitor treatment by Takahashi, Naoto, Nakaseko, Chiaki, Kobayashi, Yukio, Miyamura, Koichi, Ono, Chiho, Koide, Yuichiro, Fujii, Yosuke, Ohnishi, Kazunori

“…This long-term follow-up of a completed phase 1/2 study assessed the safety and efficacy of bosutinib in Japanese Philadelphia chromosome-positive, chronic…”
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A phase 1/2 study of bosutinib in Japanese adults with Philadelphia chromosome-positive chronic myeloid leukemia by Nakaseko, Chiaki, Takahashi, Naoto, Ishizawa, Kenichi, Kobayashi, Yukio, Ohashi, Kazuteru, Nakagawa, Yasunori, Yamamoto, Kazuhito, Miyamura, Koichi, Taniwaki, Masafumi, Okada, Masaya, Kawaguchi, Tatsuya, Shibata, Atsushi, Fujii, Yosuke, Ono, Chiho, Ohnishi, Kazunori

“…This phase 1/2 study evaluated the safety and pharmacokinetics (part 1) and efficacy and safety (part 2) of bosutinib in Japanese Philadelphia…”
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Absorption, Distribution, and Excretion of DJ-927, a Novel Orally Effective Taxane, in Mice, Dogs, and Monkeys by Ono, Chiho, Takao, Atsushi, Atsumi, Ryo

“…DJ-927, currently undergoing Phase I clinical trial, is a new orally effective taxane with potent antitumor effects. The absorption, tissue distribution, and…”
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Binding characteristics of fluoroquinolones to synthetic levodopa melanin by Ono, Chiho, Tanaka, Makoto

“…To define the binding characteristics of fluoroquinolones to synthetic levodopa melanin, the binding of various drugs, including levofloxacin and ofloxacin,…”
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High-level secretory production of phospholipase A1 by Saccharomyces cerevisiae and Aspergillus oryzae by Shiba, Y. (Sankyo Co. Ltd., Iwaki, Fukushima (Japan). Biomedical Research Labs.), Ono, C, Fukui, F, Watanabe, I, Serizawa, N, Gomi, K, Yoshikawa, H

“…Phospholipase A 1 (PLA 1 ) is a hydrolytic enzyme that catalyzes the removal of the acyl group from position 1 of lecithin to form lysolecithin. The PLA 1…”
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Nectrisine Biosynthesis Genes in Thelonectria discophora SANK 18292: Identification and Functional Analysis by Miyauchi, Ryuki, Ono, Chiho, Ohnuki, Takashi, Shiba, Yoichiro

“…The fungus Thelonectria discophora SANK 18292 produces the iminosugar nectrisine, which has a nitrogen-containing heterocyclic 5-membered ring and acts as a…”
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Absorption, distribution and excretion of 14C-levofloxacin after single oral administration in albino and pigmented rats: binding characteristics of levofloxacin-related radioactivity to melanin in vivo by Tanaka, Makoto, Ono, Chiho, Yamada, Masayoshi

“…ABSTRACT After single oral administration of 14C‐levofloxacin at a dose of 20 mg kg−1 under non‐fasting conditions, the absorption, distribution and excretion…”
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A descriptive analysis of real-world oncology biosimilar use in Japan by Roth, Joshua A, Rahshenas, Makan, Nowacki, Grégoire, Masurkar, Nihar, Shelbaya, Ahmed, Tajima, Kentaro, Dorman, Stephanie, Ono, Chiho

“…To describe patient and treatment characteristics associated with bevacizumab BS-Pfizer, rituximab BS-Pfizer and trastuzumab BS-Pfizer and their reference…”
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Efficacy and Safety of Bosutinib in Japanese Patients with Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia: Final 3-Year Results of a Phase 2 Study by Ono, Takaaki, Hino, Masayuki, Matsumura, Itaru, Fujisawa, Shin, Ishizawa, Kenichi, Sakaida, Emiko, Sekiguchi, Naohiro, Ono, Chiho, Aizawa, Mana, Tanetsugu, Yusuke, Koide, Yuichiro, Takahashi, Naoto

“…Introduction : Bosutinib is approved in Japan for patients with newly diagnosed Philadelphia chromosome-positive (Ph+) chronic phase (CP) chronic myeloid…”
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Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum by Abe, Yuki, Baba, Satoshi, Suzuki, Toshihiro, Ono, Chiho, Iwamoto, Kohji, Hosobuchi, Masahiko

“…Strain improvement through random mutagenesis, screening and selection has provided us with spontaneous mutants which could produce more ML-236B than the…”
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Isolation and Characterization of the Gene Conferring Thiamine-inducible Expression from Saccharomyces cerevisiae by SHIBA, Yoichiro, ONO, Chiho, ICHIKAWA, Kimihisa, SERIZAWA, Nobufusa, YOSHIKAWA, Hiroji

“…The production level of CPY in Saccharomyces cerevisiae KS58-2D/pCY303 was drastically decreased when thiamine was not added to the culture medium. We isolated…”
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Metabolism-dependent hepatotoxicity of amodiaquine in glutathione-depleted mice by Shimizu, Shinji, Atsumi, Ryo, Itokawa, Kenichi, Iwasaki, Masaru, Aoki, Takanori, Ono, Chiho, Izumi, Takashi, Sudo, Kenichi, Okazaki, Osamu

“…We investigated the hepatotoxicity induced by AQ using a glutathione (GSH)-depleted mice model. Although sole administration of either AQ or l -buthionine- S ,…”
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