Search Results - "Onnerfjord, P."

Quantitative three-dimensional collagen orientation analysis of human meniscus posterior horn in health and osteoarthritis using micro-computed tomography by Karjalainen, V.-P., Kestilä, I., Finnilä, M.A., Folkesson, E., Turkiewicz, A., Önnerfjord, P., Hughes, V., Tjörnstrand, J., Englund, M., Saarakkala, S.

“…Knee osteoarthritis (OA) is associated with meniscal degeneration that may involve disorganization of the meniscal collagen fiber network. Our aims were to…”
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OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis by Kraus, V.B, Blanco, F.J, Englund, M, Henrotin, Y, Lohmander, L.S, Losina, E, Önnerfjord, P, Persiani, S

“…Summary The objective of this work was to describe requirements for inclusion of soluble biomarkers in osteoarthritis (OA) clinical trials and progress toward…”
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Three-dimensional microstructure of human meniscus posterior horn in health and osteoarthritis by Kestilä, I., Folkesson, E., Finnilä, M.A., Turkiewicz, A., Önnerfjord, P., Hughes, V., Tjörnstrand, J., Englund, M., Saarakkala, S.

“…To develop and perform ex vivo 3D imaging of meniscus posterior horn microstructure using micro-computed tomography (μCT), and to compare specimens from…”
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Cartilage oligomeric matrix protein neoepitope in the synovial fluid of horses with acute lameness: A new biomarker for the early stages of osteoarthritis by Skiöldebrand, E., Ekman, S., Mattsson Hultén, L., Svala, E., Björkman, K., Lindahl, A., Lundqvist, A., Önnerfjord, P., Sihlbom, C., Rüetschi, U.

“…Summary Background Clinical tools to diagnose the early changes of osteoarthritis (OA) that occur in the articular cartilage are lacking. Objectives We sought…”
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Quantitative assessment of cartilage remodeling in health and disease by Hsueh, M.-F, Kraus, V.B, Onnerfjord, P

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Differences in protein expression using data-dependent and data-independent acquisition mass spectrometry in the analysis of human knee articular cartilage and menisci: a pilot analysis by Folkesson, E, Turkiewicz, A, Englund, M, Onnerfjord, P

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Automated assays for the quantification of total cartilage oligomeric matrix protein (COMP) and a COMP neoepitope by Lorenzo, P, Aspberg, A, Saxne, T, Onnerfjord, P

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Dexamethasone treatment alters the response of human cartilage explants to inflammatory cytokines and mechanical injury as revealed by discovery proteomics by Wang, Y, Lorenzo, P, Chubinskaya, S, Grodzinsky, A.J, Onnerfjord, P

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Targeted proteomics of hip articular cartilage in OA and fracture patients by Onnerfjord, P, Khabut, A, Hosseininia, S, Dahlberg, L

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Dexamethasone treatment in a mechanical injury cartilage explant culture model studied by proteomics by Onnerfjord, P, Wang, Y, Li, Y, Holmgren, K, Lorenzo, P, Grodzinsky, A.J

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The tyrosine sulfate domain of fibromodulin represents a new binding site to collagen enhancing the interaction and fibril formation by Tillgren, V, Onnerfjord, P, Mörgelin, M, Aspberg, A, Heinegard, D

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Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment by Wang, Y, Li, Y, Khabut, A, Chubinskaya, S, Ahrman, E, Grodzinsky, A.J, Onnerfjord, P

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Mass spectrometry profiling of non-enzymatic deamidation of articular cartilage components suggests slower protein turnover in deep regions and in hips compared with knees by Hsueh, M.-F, Khabut, A, Kjellström, S, Zura, R.D, Bolognesi, M.P, Onnerfjord, P, Kraus, V

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Interactions of histidine-rich glycoprotein with immunoglobulins and proteins of the complement system by Manderson, G.A., Martin, M., Önnerfjord, P., Saxne, T., Schmidtchen, A., Mollnes, T.E., Heinegård, D., Blom, A.M.

“…This study describes how the serum protein histidine-rich glycoprotein (HRG) affects the complement system. We show that HRG binds strongly to several…”
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Prevention of domain swapping inhibits dimerization and amyloid fibril formation of cystatin C: use of engineered disulfide bridges, antibodies, and carboxymethylpapain to stabilize the monomeric form of cystatin C by Nilsson, Maria, Wang, Xin, Rodziewicz-Motowidlo, Sylwia, Janowski, Robert, Lindström, Veronica, Onnerfjord, Patrik, Westermark, Gunilla, Grzonka, Zbigniew, Jaskolski, Mariusz, Grubb, Anders

“…Amyloidogenic proteins like cystatin C and prion proteins have been shown to form dimers by exchange of subdomains of the monomeric proteins. This process,…”
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Quantification of cartilage oligomeric matrix protein (COMP) and a COMP neoepitope in synovial fluid of patients with different joint disorders by novel automated assays by Lorenzo, P, Aspberg, A, Saxne, T, Önnerfjord, P

“…Summary Objective To develop automated immunoassays for the quantification of Cartilage Oligomeric Matrix Protein (COMP) and a COMP neoepitope in synovial…”
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Signal Amplification Using “Spot-on-a-Chip” Technology for the Identification of Proteins via MALDI-TOF MS by Ekström, Simon, Ericsson, David, Önnerfjord, Patrik, Bengtsson, Martin, Nilsson, Johan, Marko-Varga, György, Laurell, Thomas

“…The presented “spot-on-a-chip” technology enables easy enrichment of samples in the low nanomolar (1−5 nM) range and provides a fast and reliable automated…”
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Proteomic comparison of osteoarthritic and reference human menisci using data-independent acquisition mass spectrometry by Folkesson, E., Turkiewicz, A., Ali, N., Rydén, M., Hughes, H.V., Tjörnstrand, J., Önnerfjord, P., Englund, M.

“…Recent research in knee osteoarthritis (OA) highlights the role of the meniscus in OA pathology. Our aim was to compare the proteomes of medial and lateral…”
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Ultra-high field magnetic resonance imaging parameter mapping in the posterior horn of ex vivo human menisci by Olsson, E., Folkesson, E., Peterson, P., Önnerfjord, P., Tjörnstrand, J., Hughes, H.V., Englund, M., Svensson, J.

“…To investigate the relationship between meniscus magnetic resonance (MR) relaxation parameters and meniscus degradation through quantitative imaging of ex vivo…”
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3D analysis and grading of calcifications from ex vivo human meniscus by Hellberg, I., Karjalainen, V.-P., Finnilä, M.A.J., Jonsson, E., Turkiewicz, A., Önnerfjord, P., Hughes, V., Tjörnstrand, J., Englund, M., Saarakkala, S.

“…Meniscal calcifications are associated with the pathogenesis of knee osteoarthritis (OA). We propose a micro-computed tomography (μCT) based 3D analysis of…”
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