Search Results - "Onken, Jennifer L"

Senolytics improve physical function and increase lifespan in old age by Xu, Ming, Pirtskhalava, Tamar, Farr, Joshua N., Weigand, Bettina M., Palmer, Allyson K., Weivoda, Megan M., Inman, Christina L., Ogrodnik, Mikolaj B., Hachfeld, Christine M., Fraser, Daniel G., Onken, Jennifer L., Johnson, Kurt O., Verzosa, Grace C., Langhi, Larissa G. P., Weigl, Moritz, Giorgadze, Nino, LeBrasseur, Nathan K., Miller, Jordan D., Jurk, Diana, Singh, Ravinder J., Allison, David B., Ejima, Keisuke, Hubbard, Gene B., Ikeno, Yuji, Cubro, Hajrunisa, Garovic, Vesna D., Hou, Xiaonan, Weroha, S. John, Robbins, Paul D., Niedernhofer, Laura J., Khosla, Sundeep, Tchkonia, Tamara, Kirkland, James L.

“…Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction,…”
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Targeting cellular senescence prevents age-related bone loss in mice by Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, Khosla, Sundeep

“…Genetic or pharmacological depletion of senescent cells or inhibition of their function reduces bone loss in aged mice. Aging is associated with increased…”
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miR‐219a‐5p Regulates Rorβ During Osteoblast Differentiation and in Age‐related Bone Loss by Aquino‐Martinez, Ruben, Farr, Joshua N, Weivoda, Megan M, Negley, Brittany A, Onken, Jennifer L, Thicke, Brianne S, Fulcer, McKenzie M, Fraser, Daniel G, van Wijnen, Andre J, Khosla, Sundeep, Monroe, David G

“…ABSTRACT Developing novel approaches to treat skeletal disorders requires an understanding of how critical molecular factors regulate osteoblast…”
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Osteoprotection Through the Deletion of the Transcription Factor Rorβ in Mice by Farr, Joshua N, Weivoda, Megan M, Nicks, Kristy M, Fraser, Daniel G, Negley, Brittany A, Onken, Jennifer L, Thicke, Brianne S, Ruan, Ming, Liu, Hong, Forrest, Douglas, Hawse, John R, Khosla, Sundeep, Monroe, David G

“…ABSTRACT There is a clinical need to identify new molecular targets for the treatment of osteoporosis, particularly those that simultaneously inhibit bone…”
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Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice by Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, Khosla, Sundeep

“…This corrects the article DOI: 10.1038/nm.4385…”
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Correction: Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice by Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, Khosla, Sundeep

“…Nat. Med. 23, 1072–1079 (2017); published online 21 August 2017; corrected after print 11 October 2017 In the version of this article initially published, the…”
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Erratum: Corrigendum: Targeting cellular senescence prevents age-related bone loss in mice by Farr, Joshua N, Xu, Ming, Weivoda, Megan M, Monroe, David G, Fraser, Daniel G, Onken, Jennifer L, Negley, Brittany A, Sfeir, Jad G, Ogrodnik, Mikolaj B, Hachfeld, Christine M, LeBrasseur, Nathan K, Drake, Matthew T, Pignolo, Robert J, Pirtskhalava, Tamar, Tchkonia, Tamara, Oursler, Merry Jo, Kirkland, James L, Khosla, Sundeep

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