Search Results - "Onizuka, Kazumitsu"

Functional G-Quadruplex Binding Molecules by Nagatsugi, Fumi, Onizuka, Kazumitsu

“…Guanine (G)-rich sequences can form non-canonical four stranded structures known as G-quadruplexes (G4s). The G4 structure has been found in biologically…”
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Selective Chemical Modification to the Higher‐Order Structures of Nucleic Acids by Nagatsugi, Fumi, Onizuka, Kazumitsu

“…DNA and RNA can adopt a variety of stable higher‐order structural motifs, including G‐quadruplex (G4 s), mismatches, and bulges. Many of these secondary…”
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Photochemical Labeling of Nucleic Acid by Photocatalyst Tethered DNA Probe by Yamano, Yuuhei, Onizuka, Kazumitsu, Sasaki, Madoka, Sato, Shinichi, Nagatsugi, Fumi

“…A simple and novel method for photochemical labeling of nucleic acids is presented. DNA probes tethered with photocatalysts, Cat-ODNs, are newly designed…”
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Reactivity Modulation of Reactive OFF–ON Type G‑Quadruplex Alkylating Agents by Chen, Yutong, Onizuka, Kazumitsu, Hazemi, Madoka E., Nagatsugi, Fumi

“…Alkylating agents for nucleic acids have been widely used in cancer chemotherapy, as well as in chemical biology for strong inhibitors and tagging methods. We…”
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Crosstalk between repair pathways elicits double-strand breaks in alkylated DNA and implications for the action of temozolomide by Fuchs, Robert P, Isogawa, Asako, Paulo, Joao A, Onizuka, Kazumitsu, Takahashi, Tatsuro, Amunugama, Ravindra, Duxin, Julien P, Fujii, Shingo

“…Temozolomide (TMZ), a DNA methylating agent, is the primary chemotherapeutic drug used in glioblastoma treatment. TMZ induces mostly N-alkylation adducts…”
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Synthesis and properties of cross-linkable DNA duplex using 4-amino-2-oxo-6-vinyl-1,3,5-triazine by Yamada, Ken, Ishiyama, Shogo, Onizuka, Kazumitsu, Nagatsugi, Fumi

“…We synthesized the DNA oligonucleotide containing a new cross-linkable 4-amino-2-oxo-6-vinyltriazine (AOVT) nucleobase analogue (Et-AOVT) and evaluated these…”
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Structural optimization of pseudorotaxane-forming oligonucleotides for efficient and stable complex formation by Onizuka, Kazumitsu, Miyashita, Takuya, Chikuni, Tomoko, Ozawa, Mamiko, Abe, Hiroshi, Nagatsugi, Fumi

“…Abstract Interlocked structures, such as rotaxane and catenane, combine both static and dynamic properties. To expand their unique properties into the chemical…”
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Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids by Onizuka, Kazumitsu, Hazemi, Madoka E, Sato, Norihiro, Tsuji, Gen-Ichiro, Ishikawa, Shunya, Ozawa, Mamiko, Tanno, Kousuke, Yamada, Ken, Nagatsugi, Fumi

“…Higher-ordered structure motifs of nucleic acids, such as the G-quadruplex (G-4), mismatched and bulge structures, are significant research targets because…”
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Efficient Thymidine-Selective DNA Interstrand Photo-activated Crosslinking by the 6-Thioguanine Connected via an Ethylene-Linker to the 2′-Deoxyribose Unit by Nishioka, Takamasa, Oshiro, Ikuya, Onizuka, Kazumitsu, Taniguchi, Yosuke, Sasaki, Shigeki

“…Cross-linking is a widely-used technology in the studies of DNA, RNA and their complexes with proteins. Intrinsically active alkylating moieties and…”
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Structure-Guided Control of siRNA Off-Target Effects by Suter, Scott R, Sheu-Gruttadauria, Jessica, Schirle, Nicole T, Valenzuela, Rachel, Ball-Jones, Alexi A, Onizuka, Kazumitsu, MacRae, Ian J, Beal, Peter A

“…Short interfering RNAs (siRNAs) are promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA…”
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Automatic Pseudorotaxane Formation Targeting on Nucleic Acids Using a Pair of Reactive Oligodeoxynucleotides by Onizuka, Kazumitsu, Nagatsugi, Fumi, Ito, Yoshihiro, Abe, Hiroshi

“…Here we report a novel method to form a pseudorotaxane architecture using only a pair of reactive oligodeoxyribonucleotides (ODNs), which we designed and…”
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Alkylating probes for the G-quadruplex structure and evaluation of the properties of the alkylated G-quadruplex DNA by Sato, Norihiro, Takahashi, Shuntaro, Tateishi-Karimata, Hisae, Hazemi, Madoka E, Chikuni, Tomoko, Onizuka, Kazumitsu, Sugimoto, Naoki, Nagatsugi, Fumi

“…The G-quadruplex structure has been found in biologically significant regions of the genomic DNA, including the telomere and promoter regions, and is known to…”
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Site-Specific Covalent Modification of RNA Guided by Functionality-Transfer Oligodeoxynucleotides by Onizuka, Kazumitsu, Taniguchi, Yosuke, Sasaki, Shigeki

“…Efficient methods for the covalent modification of large RNA molecules should find significance utility as innovative biological tools as well as therapeutic…”
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Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling by Seo, Siyoong, Onizuka, Kazumitsu, Nishioka, Chieko, Takahashi, Eiki, Tsuneda, Satoshi, Abe, Hiroshi, Ito, Yoshihiro

“…The representative DNA-labeling agent 5-ethynyl-2'-deoxyuridine (EdU) was chemically modified to improve its function. Chemical monophosphorylation was…”
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Stabilization of the i-motif structure by the intra-strand cross-link formation by Kikuta, Kenji, Piao, Haishun, Brazier, John, Taniguchi, Yosuke, Onizuka, Kazumitsu, Nagatsugi, Fumi, Sasaki, Shigeki

“…[Display omitted] The i-motif structures are formed by oligonucleotides containing cytosine tracts under acidic conditions. The folding of the i-motif under…”
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A new strategy for site-specific alkylation of DNA using oligonucleotides containing an abasic site and alkylating probes by Sato, Norihiro, Tsuji, Genichiro, Sasaki, Yoshihiro, Usami, Akira, Moki, Takuma, Onizuka, Kazumitsu, Yamada, Ken, Nagatsugi, Fumi

“…Selective chemical reactions with DNA, such as its labelling, are very useful in many applications. In this paper, we discuss a new strategy for the selective…”
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new usage of functionalized oligodeoxynucleotide probe for site-specific modification of a guanine base within RNA by Onizuka, Kazumitsu, Taniguchi, Yosuke, Sasaki, Shigeki

“…Site-specific modification of RNA is of great significance to investigate RNA structure, function and dynamics. Recently, we reported a new method for…”
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Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries by Nagasawa, Ryosuke, Onizuka, Kazumitsu, Komatsu, Kaoru R., Miyashita, Emi, Murase, Hirotaka, Ojima, Kanna, Ishikawa, Shunya, Ozawa, Mamiko, Saito, Hirohide, Nagatsugi, Fumi

“…The large-scale analysis of small-molecule binding to diverse RNA structures is key to understanding the required interaction properties and selectivity for…”
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Guide Strand 3′-End Modifications Regulate siRNA Specificity by Valenzuela, Rachel A. P., Onizuka, Kazumitsu, Ball-Jones, Alexi A., Hu, Tiannan, Suter, Scott R., Beal, Peter A.

“…Short interfering RNA (siRNA)‐triggered gene knockdown through the RNA interference (RNAi) pathway is widely used to study gene function, and siRNA‐based…”
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Activation and Alteration of Base Selectivity by Metal Cations in the Functionality-Transfer Reaction for RNA Modification by Onizuka, Kazumitsu, Taniguchi, Yosuke, Sasaki, Shigeki

“…Previously, we reported that the 2-methylidene-1,3-diketone unit of 6-thioguanosine transferred selectively to the amino group of cytosine at pH 7.0 and that…”
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