Search Results - "Onimaru, Hiroshi"

Effects of aconitine on the respiratory activity of brainstem-spinal cord preparations isolated from newborn rats by Yoda, Shunya, Onimaru, Hiroshi, Izumizaki, Masahiko

“…Aconitine is a sodium channel opener, but its effects on the respiratory center are not well understood. We investigated the dose-dependent effects of…”
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The respiratory control mechanisms in the brainstem and spinal cord: integrative views of the neuroanatomy and neurophysiology by Ikeda, Keiko, Kawakami, Kiyoshi, Onimaru, Hiroshi, Okada, Yasumasa, Yokota, Shigefumi, Koshiya, Naohiro, Oku, Yoshitaka, Iizuka, Makito, Koizumi, Hidehiko

“…Respiratory activities are produced by medullary respiratory rhythm generators and are modulated from various sites in the lower brainstem, and which are then…”
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Effect of cisplatin on respiratory activity in neonatal rats by Ota, Shinichiro, Onimaru, Hiroshi, Izumizaki, Masahiko

“…One side effect of cisplatin, a cytotoxic platinum anticancer drug, is peripheral neuropathy; however, its central nervous system effects remain unclear. We…”
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Optogenetic Approach to Local Neuron Network Analysis of the Medullary Respiratory Center by Onimaru, Hiroshi, Ikeda, Keiko

“…Using an optogenetic approach, we analyzed a local neuron network of the respiratory center in the medulla of a brainstem-spinal cord preparation isolated from…”
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Different impacts on brain function depending on the mode of delivery by Ikeda, Keiko, Onimaru, Hiroshi, Matsuura, Tohru, Kawakami, Kiyoshi

“…•Atp1a2−/− neonates showed life or death phenotype depending the mode of delivery.•Mode of deliveries affected the levels of monoamines and proteins in…”
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Knockout of sodium pump α3 subunit gene ( Atp1a3-/- ) results in perinatal seizure and defective respiratory rhythm generation by Ikeda, Keiko, Onimaru, Hiroshi, Kawakami, Kiyoshi

“…Highlights • The mRNA of Atp1a3 is expressed in almost all regions in the neonatal mouse brain. • About half of Atp1a3-/- fetuses showed seizures immediately…”
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Structural and functional connectivity from the dorsomedial hypothalamus to the ventral medulla as a chronological amplifier of sympathetic outflow by Kono, Yosuke, Yokota, Shigefumi, Fukushi, Isato, Arima, Yosuke, Onimaru, Hiroshi, Okazaki, Shuntaro, Takeda, Kotaro, Yazawa, Itaru, Yoshizawa, Masashi, Hasebe, Yohei, Koizumi, Keiichi, Pokorski, Mieczyslaw, Toda, Takako, Sugita, Kanji, Okada, Yasumasa

“…Psychological stress activates the hypothalamus, augments the sympathetic nervous output, and elevates blood pressure via excitation of the ventral medullary…”
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Importance of rostral ventrolateral medulla neurons in determining efferent sympathetic nerve activity and blood pressure by Kumagai, Hiroo, Oshima, Naoki, Matsuura, Tomokazu, Iigaya, Kamon, Imai, Masaki, Onimaru, Hiroshi, Sakata, Katsufumi, Osaka, Motohisa, Onami, Toshiko, Takimoto, Chie, Kamayachi, Tadashi, Itoh, Hiroshi, Saruta, Takao

“…Accentuated sympathetic nerve activity (SNA) is a risk factor for cardiovascular events. In this review, we investigate our working hypothesis that potentiated…”
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CO2-Sensitive Preinspiratory Neurons of the Parafacial Respiratory Group Express Phox2b in the Neonatal Rat by Onimaru, Hiroshi, Ikeda, Keiko, Kawakami, Kiyoshi

“…Phox2b protein is a specific marker for neurons in the parafacial region of the ventral medulla, which are proposed to play a role in central chemoreception…”
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Glycine and GABAA receptors suppressively regulate the inspiratory-related calcium rise in the thoracic inspiratory cells of the neonatal rat by Mikami, Yoshihiro, Iizuka, Makito, Onimaru, Hiroshi, Izumizaki, Masahiko

“…We previously demonstrated that in an isolated brainstem-spinal cord preparation from neonatal rats, a local bath application of strychnine (a broad antagonist…”
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Effects of linalool on respiratory neuron activity in the brainstem-spinal cord preparation from newborn rats by Shibuya, Yuka, Tsuzawa, Kayo, Onimaru, Hiroshi, Izumizaki, Masahiko

“…Linalool and linalyl acetate are major components of lavender essential oil. These substances possess many biological activities, such as anti-inflammatory…”
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Involvement of cannabinoid receptors in depression of the putative nociceptive response in spinal cord preparations isolated from neonatal rats by Tsuzawa, Kayo, Onimaru, Hiroshi, Inagaki, Katsunori, Izumizaki, Masahiko

“…A metabolite of acetaminophen, AM404, which is an anandamide transporter inhibitor, induces analgesia mainly via activation of transient receptor potential…”
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Effects of acetylcholine on hypoglossal and C4 nerve activity in brainstem-spinal cord preparations from newborn rat by Katsuki, Shino, Ikeda, Keiko, Onimaru, Hiroshi, Dohi, Kenji, Izumizaki, Masahiko

“…•We studied the effects of acetylcholine (Ach) in newborn rat en bloc preparations.•ACh enhanced pre-inspiratory activity in the hypoglossal…”
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A Novel Functional Neuron Group for Respiratory Rhythm Generation in the Ventral Medulla by Onimaru, Hiroshi, Homma, Ikuo

“…We visualized respiratory neuron activity covering the entire ventral medulla using optical recordings in a newborn rat brainstem-spinal cord preparation…”
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An aromatic substance, eugenol induces distinct depressant effects on respiratory activity in different postnatal developmental stages of the rat by Kotani, Sayumi, Yazawa, Itaru, Onimaru, Hiroshi, Izumizaki, Masahiko

“…•An aromatic substance, eugenol exerts analgesic and neuroprotective effects.•We examined the effects of eugenol on respiratory activity in in vitro and in…”
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Calcium Imaging Analysis of Cellular Responses to Hypercapnia and Hypoxia in the NTS of Newborn Rat Brainstem Preparation by Onimaru, Hiroshi, Yazawa, Itaru, Takeda, Kotaro, Fukushi, Isato, Okada, Yasumasa

“…It is supposed that the nucleus of the solitary tract (NTS) in the dorsal medulla includes gas sensor cells responsive to hypercapnia or hypoxia in the central…”
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Postsynaptic mechanisms of CO2 responses in parafacial respiratory neurons of newborn rats by Onimaru, Hiroshi, Ikeda, Keiko, Kawakami, Kiyoshi

“…Key points  •  The central chemoreceptors for respiratory control in the medulla sense changes in CO2 concentration and regulate respiratory activity. • …”
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Intrinsic properties and synaptic connectivity of Phox2b-expressing neurons in rat rostral parvocellular reticular formation by Kajiwara, Risa, Nakamura, Shiro, Ikeda, Keiko, Onimaru, Hiroshi, Yoshida, Atsushi, Tsutsumi, Yumi, Nakayama, Kiyomi, Mochizuki, Ayako, Dantsuji, Masanori, Nishimura, Akiko, Tachikawa, Satoshi, Iijima, Takehiko, Inoue, Tomio

“…•Most Phox2b+ rPCRt neurons were glutamatergic, but not GABAergic/glycinergic.•The firing characteristics differ between Phox2b+ neurons in the rPCRt and…”
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Effects of riluzole on respiratory rhythm generation in the brainstem-spinal cord preparation from newborn rat by Lin, Shih Tien, Onimaru, Hiroshi

“…•Riluzole is known as a persistent sodium channel blocker.•We examined the effects of riluzole on respiratory burst activity in newborn rat medulla.•Riluzole…”
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Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice by Fukushi, Isato, Yokota, Shigefumi, Takeda, Kotaro, Terada, Jiro, Umeda, Akira, Yoshizawa, Masashi, Kono, Yosuke, Hasebe, Yohei, Onimaru, Hiroshi, Pokorski, Mieczyslaw, Okada, Yasumasa

“…•Orexin is involved in respiratory control.•Orexin is involved in shaping the hypercapnic ventilatory chemosensitivity.•Suvorexant does not affect ventilation…”
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