Angiotensin II receptor blocker partially ameliorated intrarenal hypoxia in chronic kidney disease patients: a pre-/post-study

Chronic intrarenal hypoxia has been regarded as a pathogenic factor of progressive renal damage. However, the lack of available human data has impeded the progress in this field. In this work, blood oxygen level‐dependent magnetic resonance imaging was used to determine intrarenal oxygen status pre‐...

Full description

Saved in:

Bibliographic Details
Published in:	Internal medicine journal Vol. 42; no. 4; pp. e33 - e37
Main Authors:	Manotham, K., Ongvilawan, B., Urusopone, P., Chetsurakarn, S., Tanamai, J., Limkuansuwan, P., Tungsanga, K., Eiam-Ong, S.
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Publishing Asia 01-04-2012
Subjects:	Adult angiotensin II receptor blocker Angiotensin Receptor Antagonists - pharmacology Angiotensin Receptor Antagonists - therapeutic use blood oxygen level-dependent magnetic resonance imaging chronic kidney disease Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Female Humans hypoxia Hypoxia - drug therapy Hypoxia - metabolism Imidazoles - pharmacology Imidazoles - therapeutic use Kidney - blood supply Kidney - drug effects kidney failure Magnetic Resonance Imaging Male Middle Aged Oxygen - blood Renal Insufficiency, Chronic - drug therapy Renal Insufficiency, Chronic - metabolism Tetrazoles - pharmacology Tetrazoles - therapeutic use Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Chronic intrarenal hypoxia has been regarded as a pathogenic factor of progressive renal damage. However, the lack of available human data has impeded the progress in this field. In this work, blood oxygen level‐dependent magnetic resonance imaging was used to determine intrarenal oxygen status pre‐ and post‐angiotensin receptor blockade (olmesartan) treatment in normal subjects, diabetic chronic kidney disease (CKD) patients and non‐diabetic CKD patients. The mean R2, which represents intrarenal oxygenation, was significantly lower in the control group than in the CKD group (12.42 ± 0.53 /s vs 18.89 ± 3.15 /s, P < 0.01), indicating the presence of intrarenal hypoxia in the CKD patients. The olmesartan treatment induced a 16.2 ± 7.7% decrement of the mean R2 in CKD patients, suggesting that this drug had an intrarenal hypoxia ameliorating effect.
Bibliography:	ark:/67375/WNG-9KTPLKS4-B istex:A163AD29F222BF421CF7FBEC31AFADD50251DFD9 ArticleID:IMJ2610 Funding: The Kidney Foundation of Thailand. Conflict of interest: None. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1444-0903 1445-5994
DOI:	10.1111/j.1445-5994.2011.02610.x