Search Results - "Ong, Wei‐Yi"

Role of the Prefrontal Cortex in Pain Processing by Ong, Wei-Yi, Stohler, Christian S., Herr, Deron R.

“…The prefrontal cortex (PFC) is not only important in executive functions, but also pain processing. The latter is dependent on its connections to other areas…”
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A Flexi‐PEGDA Upconversion Implant for Wireless Brain Photodynamic Therapy by Teh, Daniel Boon Loong, Bansal, Akshaya, Chai, Chou, Toh, Tan Boon, Tucker, Robert Alan Jappy, Gammad, Gil Gerald Lasam, Yeo, Yanzhuang, Lei, Zhendong, Zheng, Xiang, Yang, Fengyuan, Ho, John S., Bolem, Nagarjun, Wu, Bing Cheng, Gnanasammandhan, Muthu Kumar, Hooi, Lissa, Dawe, Gavin Stewart, Libedinsky, Camilo, Ong, Wei‐Yi, Halliwell, Barry, Chow, Edward Kai‐Hua, Lim, Kah‐Leong, Zhang, Yong, Kennedy, Brian K.

“…Near‐infrared (NIR) activatable upconversion nanoparticles (UCNPs) enable wireless‐based phototherapies by converting deep‐tissue‐penetrating NIR to visible…”
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Lewy Body–like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α‐Synuclein Mutations by Jo, Junghyun, Yang, Lin, Tran, Hoang‐Dai, Yu, Weonjin, Sun, Alfred Xuyang, Chang, Ya Yin, Jung, Byung Chul, Lee, Seung‐Jae, Saw, Tzuen Yih, Xiao, Bin, Khoo, Audrey Tze Ting, Yaw, Lai‐Ping, Xie, Jessica Jiaxin, Lokman, Hidayat, Ong, Wei‐Yi, Lim, Grace Gui Yin, Lim, Kah‐Leong, Tan, Eng‐King, Ng, Huck‐Hui, Je, Hyunsoo Shawn

“…Objective We utilized human midbrain‐like organoids (hMLOs) generated from human pluripotent stem cells carrying glucocerebrosidase gene (GBA1) and α‐synuclein…”
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Pleotropic Roles of Autotaxin in the Nervous System Present Opportunities for the Development of Novel Therapeutics for Neurological Diseases by Herr, Deron R., Chew, Wee Siong, Satish, R. L., Ong, Wei-Yi

“…Autotaxin (ATX) is a soluble extracellular enzyme that is abundant in mammalian plasma and cerebrospinal fluid (CSF). It has two known enzymatic activities,…”
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Qi Fu Yin–a Ming Dynasty Prescription for the Treatment of Dementia by Ong, Wei-Yi, Wu, Ya-Jun, Farooqui, Tahira, Farooqui, Akhlaq A.

“…The Traditional Chinese Medicine (TCM) theory that “kidneys give rise to marrow, and the brain is the sea of marrow” has been a guide for the clinical…”
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Biodistribution of gold nanoparticles and gene expression changes in the liver and spleen after intravenous administration in rats by Balasubramanian, Suresh K, Jittiwat, Jinatta, Manikandan, Jayapal, Ong, Choon-Nam, Yu, Liya E, Ong, Wei-Yi

“…Abstract Biodistribution of gold nanoparticles (AuNPs) in more than 25 organs were examined on 1 day, 1 week, 1 month and 2 months after a single intravenous…”
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Effects of Antimalarial Drugs on Neuroinflammation-Potential Use for Treatment of COVID-19-Related Neurologic Complications by Ong, Wei-Yi, Go, Mei-Lin, Wang, De-Yun, Cheah, Irwin Kee-Mun, Halliwell, Barry

“…The SARS-CoV-2 virus that is the cause of coronavirus disease 2019 (COVID-19) affects not only peripheral organs such as the lungs and blood vessels, but also…”
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Ayurvedic Medicine for the Treatment of Dementia: Mechanistic Aspects by Ong, Jolin Hwee-Jing, Madan, Anil, Farooqui, Tahira, Farooqui, Akhlaq A., Ong, Wei-Yi

“…Ayurvedic medicine is a personalized system of traditional medicine native to India and the Indian subcontinent. It is based on a holistic view of treatment…”
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Anti-Inflammatory Effects of Phytochemical Components of Clinacanthus nutans by Ong, Wei-Yi, Herr, Deron R, Sun, Grace Y, Lin, Teng-Nan

“…Recent studies on the ethnomedicinal use of suggest promising anti-inflammatory, anti-tumorigenic, and antiviral properties for this plant. Extraction of the…”
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Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells by Soh, Sandra, Ong, Wei-Yi

“…Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha ( , fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated…”
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Effect of Ergothioneine on 7-Ketocholesterol-Induced Endothelial Injury by Koh, Sally Shuxian, Ooi, Samantha Chia-Yi, Lui, Natalie Man-Yin, Qiong, Cao, Ho, Leona Ting-Yuke, Cheah, Irwin Kee-Mun, Halliwell, Barry, Herr, Deron R., Ong, Wei-Yi

“…Ergothioneine (ET) is a naturally occurring antioxidant that is synthesized by non-yeast fungi and certain bacteria. ET is not synthesized by animals,…”
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Anti-inflammatory and Cytoprotective Effect of Clinacanthus nutans Leaf But Not Stem Extracts on 7-Ketocholesterol Induced Brain Endothelial Cell Injury by Kuo, Xuan, Herr, Deron R., Ong, Wei-Yi

“…Clinacanthus nutans (Lindau) ( C. nutans ) has diverse uses in traditional herbal medicine for treating skin rashes, insect and snake bites, lesions caused by…”
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Protective Effect of Ergothioneine against 7-Ketocholesterol-Induced Mitochondrial Damage in hCMEC/D3 Human Brain Endothelial Cells by Leow, Damien Meng-Kiat, Cheah, Irwin Kee-Mun, Fong, Zachary Wei-Jie, Halliwell, Barry, Ong, Wei-Yi

“…Recent findings have suggested that the natural compound ergothioneine (ET), which is synthesised by certain fungi and bacteria, has considerable…”
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Inhibitors of Brain Phospholipase A2 Activity: Their Neuropharmacological Effects and Therapeutic Importance for the Treatment of Neurologic Disorders by Farooqui, Akhlaq A, Ong, Wei-Yi, Horrocks, Lloyd A

“…The phospholipase A 2 family includes secretory phospholipase A 2 , cytosolic phospholipase A 2 , plasmalogen-selective phospholipase A 2 , and…”
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Protective effects of ginseng on neurological disorders by Ong, Wei-Yi, Farooqui, Tahira, Koh, Hwee-Ling, Farooqui, Akhlaq A, Ling, Eng-Ang

“…Ginseng (Order: Apiales, Family: Araliaceae, Genus: Panax) has been used as a traditional herbal medicine for over 2000 years, and is recorded to have…”
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The effect of primary particle size on biodistribution of inhaled gold nano-agglomerates by Balasubramanian, Suresh K, Poh, Kay-Wee, Ong, Choon-Nam, Kreyling, Wolfgang G, Ong, Wei-Yi, Yu, Liya E

“…Abstract Airborne engineered nanoparticles undergo agglomeration, and careful distinction must be made between primary and agglomerate size of particles, when…”
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Ultrastructural Characteristics of DHA-Induced Pyroptosis by Herr, Deron R., Yam, Ting Yu Amelia, Tan, Wan Shun Daniel, Koh, Sally Shuxian, Wong, Wai Shiu Fred, Ong, Wei-Yi, Chayaburakul, Kanokporn

“…Microglial cells are resident macrophages of the central nervous system (CNS) that respond to bioactive lipids such as docosahexaenoic acid (DHA). Low…”
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Nose-to-brain drug delivery by nanoparticles in the treatment of neurological disorders by Ong, Wei-Yi, Shalini, Suku-Maran, Costantino, Luca

“…Many potential drugs for the treatment of neurological diseases are unable to reach the brain in sufficient enough concentrations to be therapeutic because of…”
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Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth by Ho, Christabel Fung-Yih, Ismail, Nadia Binte, Koh, Joled Kong-Ze, Gunaseelan, Saravanan, Low, Yi-Hua, Ng, Yee-Kong, Chua, John Jia-En, Ong, Wei-Yi

“…Arachidonic acid and docosahexaenoic acid (DHA) released by the action of phospholipases A 2 (PLA 2 ) on membrane phospholipids may be metabolized by…”
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Metabolism of Docosahexaenoic Acid (DHA) Induces Pyroptosis in BV-2 Microglial Cells by Srikanth, Malavika, Chandrasaharan, Kalashobini, Zhao, Xinyuan, Chayaburakul, Kanokporn, Ong, Wei-Yi, Herr, Deron R.

“…DHA is one of the most abundant fatty acids in the brain, largely present in stores of membrane phospholipids. It is readily released by the action of…”
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