Search Results - "Ong, Luvena L."
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Three-Dimensional Structures Self-Assembled from DNA Bricks
Published in Science (American Association for the Advancement of Science) (30-11-2012)“…We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call "DNA bricks."…”
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Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components
Published in Nature (London) (07-12-2017)“…DNA bricks with binding domains of 13 nucleotides instead of the typical 8 make it possible to self-assemble gigadalton-scale, three-dimensional nanostructures…”
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Cooperative Nanoparticles for Tumor Detection and Photothermally Triggered Drug Delivery
Published in Advanced materials (Weinheim) (23-02-2010)“…A cooperative nanosystem consisting of two distinct nanomaterials works in vivo to detect tumor tissues and deliver drugs to the site. Gold nanorods (GNRs)…”
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Humanized mice with ectopic artificial liver tissues
Published in Proceedings of the National Academy of Sciences - PNAS (19-07-2011)“…"Humanized" mice offer a window into aspects of human physiology that are otherwise inaccessible. The best available methods for liver humanization rely on…”
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Barcode extension for analysis and reconstruction of structures
Published in Nature communications (13-03-2017)“…Collections of DNA sequences can be rationally designed to self-assemble into predictable three-dimensional structures. The geometric and functional diversity…”
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DNA brick crystals with prescribed depths
Published in Nature chemistry (01-11-2014)“…The ability to assemble functional materials with precise spatial arrangements is important for applications ranging from protein crystallography to…”
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Understanding Förster Resonance Energy Transfer in the Sheet Regime with DNA Brick-Based Dye Networks
Published in ACS nano (26-10-2021)“…Controlling excitonic energy transfer at the molecular level is a key requirement for transitioning nanophotonics research to viable devices with the main…”
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Complex DNA Brick Assembly
Published in Methods in molecular biology (Clifton, N.J.) (2017)“…DNA nanostructures are a useful technology for precisely organizing and manipulating nanomaterials. The DNA bricks method is a modular and versatile platform…”
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Hierarchical Assembly of DNA Nanostructures Based on Four-Way Toehold-Mediated Strand Displacement
Published in Nano letters (08-08-2018)“…Because of its attractive cost and yield, hierarchical assembly, in which constituent structures of lower hierarchy share a majority of components, is an…”
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Complex Reconfiguration of DNA Nanostructures
Published in Angewandte Chemie International Edition (14-07-2014)“…Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold‐mediated strand displacement has enabled the construction of…”
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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Published in Proceedings of the National Academy of Sciences - PNAS (02-01-2024)“…The salt-inducible kinases (SIK) 1-3 are key regulators of pro- versus anti-inflammatory cytokine responses during innate immune activation. The lack of highly…”
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A Compact DNA Cube with Side Length 10 nm
Published in Small (Weinheim an der Bergstrasse, Germany) (01-10-2015)“…A small and compact DNA cube with zeptoliter volume is constructed by means of a generalized DNA brick concept using short synthetic oligonucleotides with…”
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13
Complex Reconfiguration of DNA Nanostructures
Published in Angewandte Chemie (14-07-2014)“…Nucleic acids have been used to create diverse synthetic structural and dynamic systems. Toehold‐mediated strand displacement has enabled the construction of…”
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14
Sub-100-nm metafluorophores with digitally tunable optical properties self-assembled from DNA
Published in Science advances (01-06-2017)“…Fluorescence microscopy allows specific target detection down to the level of single molecules and has become an enabling tool in biological research. To…”
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Understanding Förster Resonance Energy Transfer in the Sheet Regime with DNA Brick-Based Dye Networks
Published in ACS nano (26-10-2021)“…Controlling excitonic energy transfer at the molecular level is a key requirement for transitioning nanophotonics research to viable devices with the main…”
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Programmable self-assembly of three-dimensional nanostructures from 104 unique components
Published in Nature (London) (06-12-2017)“…Nucleic acids (DNA and RNA) are widely used to construct nanoscale structures with ever increasing complexity 1 – 14 for possible applications in fields as…”
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DNA Brick Crystals with Prescribed Depth
Published in Nature chemistry (19-10-2014)“…We describe a general framework for constructing two-dimensional crystals with prescribed depth and sophisticated three-dimensional features. These crystals…”
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Humanized mice with ectopic artificial liver tissues
Published in Proceedings of the National Academy of Sciences - PNAS (19-07-2011)“…"Humanized" mice offer a window into aspects of human physiology that are otherwise inaccessible. The best available methods for liver humanization rely on…”
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Journal Article