Search Results - "Ong, Li Ching"

Changes in complement alternative pathway components, factor B and factor H during dengue virus infection in the AG129 mouse by Cabezas-Falcon, Sheila, Norbury, Aidan J, Hulme-Jones, Jarrod, Klebe, Sonja, Adamson, Penelope, Rudd, Penny A, Mahalingam, Suresh, Ong, Li-Ching, Alonso, Sylvie, Gordon, David L, Carr, Jillian M

“…The complement alternative pathway (AP) is tightly regulated and changes in two important AP components, factor B (FB) and factor H (FH) are linked to severe…”
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Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope by Robinson, Luke N., Tharakaraman, Kannan, Rowley, Kirk J., Costa, Vivian V., Chan, Kuan Rong, Wong, Yee Hwa, Ong, Li Ching, Tan, Hwee Cheng, Koch, Tyree, Cain, David, Kirloskar, Rama, Viswanathan, Karthik, Liew, Chong Wai, Tissire, Hamid, Ramakrishnan, Boopathy, Myette, James R., Babcock, Gregory J., Sasisekharan, V., Alonso, Sylvie, Chen, Jianzhu, Lescar, Julien, Shriver, Zachary, Ooi, Eng Eong, Sasisekharan, Ram

“…Dengue is the most common vector-borne viral disease, causing nearly 400 million infections yearly. Currently there are no approved therapies. Antibody…”
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Expansion of human bone marrow-derived mesenchymal stromal cells with enhanced immunomodulatory properties by Neo, Shu Hui, Her, Zhisheng, Othman, Rashidah, Tee, Ching Ann, Ong, Li Ching, Wang, Yuehua, Tan, Irwin, Tan, Jaylen, Yang, Yanmeng, Yang, Zheng, Chen, Qingfeng, Boyer, Laurie A

“…Abstract Background Mesenchymal stromal cells (MSCs) have broad potential as a cell therapy including for the treatment of drug-resistant inflammatory…”
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Relative Contribution of Dengue IgG Antibodies Acquired during Gestation or Breastfeeding in Mediating Dengue Disease Enhancement and Protection in Type I Interferon Receptor-Deficient Mice by Lee, Pei Xuan, Ong, Li Ching, Libau, Eshele Anak, Alonso, Sylvie

“…Dengue virus (DENV) causes a spectrum of diseases ranging from self-limiting dengue fever to severe conditions such as haemorrhagic fever and dengue shock…”
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Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism by Ye, Liang, Schnepf, Daniel, Ohnemus, Annette, Ong, Li Ching, Gad, Hans Henrik, Hartmann, Rune, Lycke, Nils, Staeheli, Peter

“…Previous work showed that interferon-λ (IFN-λ) can trigger the synthesis of thymic stromal lymphopoietin (TSLP) by specialized epithelial cells in the upper…”
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Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein by Budigi, Yadunanda, Ong, Eugenia Z, Robinson, Luke N, Ong, Li Ching, Rowley, Kirk J, Winnett, Alexander, Tan, Hwee Cheng, Hobbie, Sven, Shriver, Zachary, Babcock, Gregory J, Alonso, Sylvie, Ooi, Eng Eong

“…Dengue virus (DENV) infection imposes enormous health and economic burden worldwide with no approved treatment. Several small molecules, including lovastatin,…”
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Maternal Antibody-Mediated Disease Enhancement in Type I Interferon-Deficient Mice Leads to Lethal Disease Associated with Liver Damage by Martínez Gómez, Julia María, Ong, Li Ching, Lam, Jian Hang, Binte Aman, Siti Amanlina, Libau, Eshele Anak, Lee, Pei Xuan, St John, Ashley L, Alonso, Sylvie

“…Epidemiological studies have reported that most of the severe dengue cases occur upon a secondary heterologous infection. Furthermore, babies born to dengue…”
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Upconversion: road to El Dorado of the fluorescence world by Ong, Li Ching, Gnanasammandhan, Muthu Kumara, Nagarajan, Sounderya, Zhang, Yong

“…Upconversion nanoparticles (UCNs), in the recent times have attracted attention due to their unique properties, which makes them ideal fluorophores for use in…”
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Bacterial imaging with photostable upconversion fluorescent nanoparticles by Ong, Li Ching, Ang, Lei Yin, Alonso, Sylvie, Zhang, Yong

“…Abstract Autofluorescence, photodamage and photobleaching are often encountered when using downconverting fluorophores and fluorescent proteins for bacteria…”
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Applications of upconversion nanoparticles in imaging, detection and therapy by Ang, Lei Yin, Lim, Meng Earn, Ong, Li Ching, Zhang, Yong

“…Upconversion nanoparticles (UCNs) are an emerging class of luminescent nanomaterials, exhibiting many advantages over conventional fluorophores, such as high…”
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Relative contribution of nonstructural protein 1 in dengue pathogenesis by Lee, Pei Xuan, Ting, Donald Heng Rong, Boey, Clement Peng Hee, Tan, Eunice Tze Xin, Chia, Janice Zuo Hui, Idris, Fakhriedzwan, Oo, Yukei, Ong, Li Ching, Chua, Yen Leong, Hapuarachchi, Chanditha, Ng, Lee Ching, Alonso, Sylvie

“…Dengue is a major public health concern in the tropical and subtropical world, with no effective treatment. The controversial live attenuated virus vaccine…”
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Type I and Type III Interferons Differ in Their Adjuvant Activities for Influenza Vaccines by Ye, Liang, Ohnemus, Annette, Ong, Li Ching, Gad, Hans Henrik, Hartmann, Rune, Lycke, Nils, Staeheli, Peter

“…Type I and type III interferons (IFNs) can promote adaptive immune responses in mice and improve vaccine-induced resistance to viral infections. The adjuvant…”
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Clonotypic analysis of protective influenza M2e-specific lung resident Th17 memory cells reveals extensive functional diversity by Omokanye, Ajibola, Ong, Li Ching, Lebrero-Fernandez, Cristina, Bernasconi, Valentina, Schön, Karin, Strömberg, Anneli, Bemark, Mats, Saelens, Xavier, Czarnewski, Paulo, Lycke, Nils

“…The fate of tissue-resident memory CD4 T cells (Trm) has been incompletely investigated. Here we show that intranasal, but not parenteral, immunization with…”
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Key concepts, strategies, and challenges in dengue vaccine development: an opportunity for sub-unit candidates? by Lam, Jian Hang, Ong, Li Ching, Alonso, Sylvie

“…Despite 70 years of research that has intensified in the past decade, a safe and efficacious dengue vaccine has yet to be available. In addition to the…”
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Allergic sensitization impairs lung resident memory CD8 T-cell response and virus clearance by Agrawal, Komal, Ong, Li Ching, Monkley, Susan, Thörn, Kristofer, Israelsson, Elisabeth, Baturcam, Engin, Rist, Cassie, Schön, Karin, Blake, Sophia, Magnusson, Björn, Cartwright, James, Mitra, Suman, Ravi, Abilash, Zounemat-Kermani, Nazanin, Krishnaswamy, Jayendra Kumar, Lycke, Nils Y., Gehrmann, Ulf, Mattsson, Johan

“…Patients with asthma often suffer from frequent respiratory viral infections and reduced virus clearance. Lung resident memory T cells provide rapid protection…”
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A vaccine combination of lipid nanoparticles and a cholera toxin adjuvant derivative greatly improves lung protection against influenza virus infection by Bernasconi, Valentina, Norling, Karin, Gribonika, Inta, Ong, Li Ching, Burazerovic, Sabina, Parveen, Nagma, Schön, Karin, Stensson, Anneli, Bally, Marta, Larson, Göran, Höök, Fredrik, Lycke, Nils

“…This is a proof-of-principle study demonstrating that the combination of a cholera toxin derived adjuvant, CTA1-DD, and lipid nanoparticles (LNP) can…”
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Dengue virus infects the mouse eye following systemic or intracranial infection and induces inflammatory responses by Norbury, Aidan J, Calvert, Julie K, Al-Shujairi, Wisam H, Cabezas-Falcon, Sheila, Tang, Victoria, Ong, Li Ching, Alonso, Sylvie L, Smith, Justine R, Carr, Jillian M

“…Dengue virus (DENV) infection is associated with clinical ocular presentations and here DENV infection of the eye was assessed in mice. In an AG129 mouse model…”
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Interactive Mixture as a Rapid Drug Delivery System by Lee, Chin Chiat, Ong, Charlene Li Ching, Heng, Paul Wan Sia, Chan, Lai Wah, Wong, Tin Wui

“…The effectiveness of an interactive mixture as a rapid drug delivery system is compared with that of a solid dispersion. The influences of drug load, particle…”
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Upconversion: road to EI Dorado of the fluorescence world by Ong, Li Ching, Gnanasammandhan, Muthu Kumara, Nagarajan, Sounderya, Zhang, Yong

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