Search Results - "Ong, H. T."

A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region by Png, Eileen, Thalamuthu, Anbupalam, Ong, Rick T.H., Snippe, Harm, Boland, Greet J., Seielstad, Mark

“…We performed a two-stage genome-wide association study (GWAS) of antibody titer in 3614 hepatitis B vaccine recipients from Indonesia's Riau Archipelago,…”
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A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis by Padyukov, Leonid, Seielstad, Mark, Ong, Rick T H, Ding, Bo, Rönnelid, Johan, Seddighzadeh, Maria, Alfredsson, Lars, Klareskog, Lars

“…Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA). Until…”
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Factors Controlling Instability of Homogeneous Soil Slopes under Rainfall by Rahardjo, H, Ong, T. H, Rezaur, R. B, Leong, E. C

“…Rainfall-induced slope failure is a common geotechnical problem in the tropics where residual soils are abundant. Although the significance of rainwater…”
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Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations by Okada, Yukinori, Kim, Kwangwoo, Han, Buhm, Pillai, Nisha E, Ong, Rick T-H, Saw, Woei-Yuh, Luo, Ma, Jiang, Lei, Yin, Jian, Bang, So-Young, Lee, Hye-Soon, Brown, Matthew A, Bae, Sang-Cheol, Xu, Huji, Teo, Yik-Ying, de Bakker, Paul I W, Raychaudhuri, Soumya

“…Previous studies have emphasized ethnically heterogeneous human leukocyte antigen (HLA) classical allele associations to rheumatoid arthritis (RA) risk. We…”
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Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion by Alieva, N. O., Efremov, A. K., Hu, S., Oh, D., Chen, Z., Natarajan, M., Ong, H. T., Jégou, A., Romet-Lemonne, G., Groves, J. T., Sheetz, M. P., Yan, J., Bershadsky, A. D.

“…Filopodia, dynamic membrane protrusions driven by polymerization of an actin filament core, can adhere to the extracellular matrix and experience both external…”
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β blockers in hypertension and cardiovascular disease by Ong, H T

“…This review provides practical pointers on the use of β blockers for the non-specialist clinician…”
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Evaluation of T cells as carriers for systemic measles virotherapy in the presence of antiviral antibodies by ONG, H. T, HASEGAWA, K, DIETZ, A. B, RUSSELL, S. J, PENG, K.-W

“…Neutralizing antiviral antibodies (Abs) can hinder systemic virotherapy. Here, we used activated T cells as carriers to deliver oncolytic measles viruses (MV)…”
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Evidence-based prescribing of statins: a developing world perspective by Ong, H T

“…Although statins reduce the incidence of cardiovascular disease, they are expensive. How should trial evidence on statins be applied to a resource-poor setting?…”
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Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations by Dorajoo, R, Blakemore, A I F, Sim, X, Ong, R T-H, Ng, D P K, Seielstad, M, Wong, T-Y, Saw, S-M, Froguel, P, Liu, J, Tai, E-S

“…Objective: Recent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations. However, their contribution to…”
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Natural positive selection and north-south genetic diversity in East Asia by CHENSUO, HAIYANXU, JIANJUN LIU, TAI, E-Shyong, WONG, Tien-Yin, CHIA, Kee-Seng, TEO, Yik-Ying, KHOR, Chiea-Chuen, TH ONG, Rick, SIM, Xueling, JIEMING CHEN, TAY, Wan-Ting, SIM, Kar-Seng, ZENG, Yi-Xin, XUEJUN ZHANG

“…Recent reports have identified a north-south cline in genetic variation in East and South-East Asia, but these studies have not formally explored the basis of…”
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Parent‐ and Patient‐ Validated Content for Pediatric Epilepsy Quality‐of‐Life Assessment by Arunkumar, G., Wyllie, E., Kotagal, P., Ong, H. T., Gilliam, F.

“…Purpose: The purpose of this study was to assess the parent‐ and patient‐validated content of quality‐of‐life measurement for use in children with epilepsy…”
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Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1 by Hibberd, Martin L, Simmons, Cameron P, Khor, Chiea Chuen, Chau, Tran Nguyen Bich, Pang, Junxiong, Davila, Sonia, Long, Hoang Truong, Ong, Rick T H, Dunstan, Sarah J, Wills, Bridget, Farrar, Jeremy, Van Tram, Ta, Gan, Tran Thi, Binh, Nguyen Thi Nguyet, Tri, Le Trung, Lien, Le Bich, Tuan, Nguyen Minh, Tham, Nguyen Thi Hong, Lanh, Mai Ngoc, Nguyet, Nguyen Minh, Hieu, Nguyen Trong, Van N Vinh Chau, Nguyen, Thuy, Tran Thi, Tan, Dennis E K, Sakuntabhai, Anavaj, Teo, Yik-Ying

“…Hypovolemic shock (dengue shock syndrome (DSS)) is the most common life-threatening complication of dengue. We conducted a genome-wide association study of…”
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The statin studies: from targeting hypercholesterolaemia to targeting the high-risk patient by Ong, H T

“…The landmark HMG-CoA reductase inhibitor (statin) studies have practical lessons for clinicans. The 4S trial established the importance of treating the…”
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Whole genome sequencing analysis of multidrug-resistant tuberculosis in Singapore, 2006–2018 by Chee, Cynthia B. E., Lim, Leo K. Y., Ong, Rick T. H., Sng, Li Hwei, Hsu, Li Yang, Lee, Vernon J. M., Wang, Yee Tang

“…There were 290 multidrug-resistant (MDR)-TB cases diagnosed in Singapore from 2006 to 2018. Eighty-one percent were foreign-born. Spoligotyping and MIRU-VNTR…”
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Simple aspiration versus chest-tube insertion in the management of primary spontaneous pneumothorax: a systematic review by Devanand, A, Koh, M.S, Ong, T.H, Low, S.Y, Phua, G.C, Tan, K.L, Philip Eng, C.T, Samuel, M

“…Background: The initial treatment of a primary spontaneous pneumothorax (PSP) is controversial. Guidelines of the British Thoracic Society recommend simple…”
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Cardiovascular outcomes in the comparative hypertension drug trials: more consensus than controversy by Ong, H T

“…The comparative anti-hypertensive drug trials conducted to assess their cardiovascular protective efficacy actually produce compatible, not conflicting,…”
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Cholesterol, statins, and mortality by Ong, HT, Haniffah, AG

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Long‐term future risk of severe exacerbations: Distinct 5‐year trajectories of problematic asthma by Yii, A. C. A., Tan, J. H. Y., Lapperre, T. S., Chan, A. K. W., Low, S. Y., Ong, T. H., Tan, K. L., Chotirmall, S. H., Sterk, P. J., Koh, M. S.

“…Background Assessing future risk of exacerbations is an important component of asthma management. Existing studies have investigated short‐ but not long‐term…”
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The contribution of recently identified adult BMI risk loci to paediatric obesity in a Singaporean Chinese childhood dataset by Dorajoo, R., Ong, R. T‐H., Sim, X., Wang, L., Liu, W., Tai, E. S., Liu, J., Saw, S‐M.

“…Summary Introduction Recent genome‐wide association studies have identified 103 adult obesity risk loci; however, it is unclear if these findings are relevant…”
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Pulmonary function and scoliosis in children with spinal muscular atrophy types II and III by Chng, SY, Wong, YQ, Hui, JH, Wong, HK, Ong, HT, Goh, DY

“…Aims:  The objectives were to evaluate the clinical course of spinal muscular atrophy (SMA) types II and III patients necessitating scoliosis surgery at the…”
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