Search Results - "Ong, Giang T."

High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging by He, Shanshan, Bhatt, Ruchir, Brown, Carl, Brown, Emily A., Buhr, Derek L., Chantranuvatana, Kan, Danaher, Patrick, Dunaway, Dwayne, Garrison, Ryan G., Geiss, Gary, Gregory, Mark T., Hoang, Margaret L., Khafizov, Rustem, Killingbeck, Emily E., Kim, Dae, Kim, Tae Kyung, Kim, Youngmi, Klock, Andrew, Korukonda, Mithra, Kutchma, Alecksandr, Lewis, Zachary R., Liang, Yan, Nelson, Jeffrey S., Ong, Giang T., Perillo, Evan P., Phan, Joseph C., Phan-Everson, Tien, Piazza, Erin, Rane, Tushar, Reitz, Zachary, Rhodes, Michael, Rosenbloom, Alyssa, Ross, David, Sato, Hiromi, Wardhani, Aster W., Williams-Wietzikoski, Corey A., Wu, Lidan, Beechem, Joseph M.

“…Resolving the spatial distribution of RNA and protein in tissues at subcellular resolution is a challenge in the field of spatial biology. We describe spatial…”
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High-Plex Predictive Marker Discovery for Melanoma Immunotherapy-Treated Patients Using Digital Spatial Profiling by Toki, Maria I, Merritt, Christopher R, Wong, Pok Fai, Smithy, James W, Kluger, Harriet M, Syrigos, Konstantinos N, Ong, Giang T, Warren, Sarah E, Beechem, Joseph M, Rimm, David L

“…Protein expression in formalin-fixed, paraffin-embedded tissue is routinely measured by IHC or quantitative fluorescence (QIF) on a handful of markers on a…”
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A polyploid admixed origin of beer yeasts derived from European and Asian wine populations by Fay, Justin C, Liu, Ping, Ong, Giang T, Dunham, Maitreya J, Cromie, Gareth A, Jeffery, Eric W, Ludlow, Catherine L, Dudley, Aimée M

“…Strains of Saccharomyces cerevisiae used to make beer, bread, and wine are genetically and phenotypically distinct from wild populations associated with trees…”
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High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations by Payen, Celia, Sunshine, Anna B, Ong, Giang T, Pogachar, Jamie L, Zhao, Wei, Dunham, Maitreya J

“…High-throughput sequencing has enabled genetic screens that can rapidly identify mutations that occur during experimental evolution. The presence of a mutation…”
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The fitness consequences of aneuploidy are driven by condition-dependent gene effects by Sunshine, Anna B, Payen, Celia, Ong, Giang T, Liachko, Ivan, Tan, Kean Ming, Dunham, Maitreya J

“…Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell's proliferative ability, or cellular fitness, has…”
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Comprehensive Analysis of the SUL1 Promoter of Saccharomyces cerevisiae by Rich, Matthew S, Payen, Celia, Rubin, Alan F, Ong, Giang T, Sanchez, Monica R, Yachie, Nozomu, Dunham, Maitreya J, Fields, Stanley

“…In the yeast Saccharomyces cerevisiae, beneficial mutations selected during sulfate-limited growth are typically amplifications of the SUL1 gene, which encodes…”
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Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae by Sunshine, Anna B., Ong, Giang T., Nickerson, Daniel P., Carr, Daniel, Murakami, Christopher J., Wasko, Brian M., Shemorry, Anna, Merz, Alexey J., Kaeberlein, Matt, Dunham, Maitreya J.

“…Summary Aneuploidy and aging are correlated; however, a causal link between these two phenomena has remained elusive. Here, we show that yeast disomic for a…”
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Multiplex digital spatial profiling of proteins and RNA in fixed tissue by Merritt, Christopher R., Ong, Giang T., Church, Sarah E., Barker, Kristi, Danaher, Patrick, Geiss, Gary, Hoang, Margaret, Jung, Jaemyeong, Liang, Yan, McKay-Fleisch, Jill, Nguyen, Karen, Norgaard, Zach, Sorg, Kristina, Sprague, Isaac, Warren, Charles, Warren, Sarah, Webster, Philippa J., Zhou, Zoey, Zollinger, Daniel R., Dunaway, Dwayne L., Mills, Gordon B., Beechem, Joseph M.

“…Digital Spatial Profiling (DSP) is a method for highly multiplex spatial profiling of proteins or RNAs suitable for use on formalin-fixed, paraffin-embedded…”
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Multiplatform Analysis of Intratumoral PTEN Heterogeneity in Melanoma by Chagani, Sharmeen, De Macedo, Mariana P., Carapeto, Fernando, Wang, Feng, Marzese, Diego M., Wani, Khalida, Haydu, Lauren E., Peng, Weiyi, Ong, Giang T., Warren, Sarah E., Beechem, Joseph M., Hoon, Dave S.B., Mills, Gordon B., Tetzlaff, Michael T., Lazar, Alexander J., Kwong, Lawrence N., Davies, Michael A.

“…Loss of protein expression of the tumor suppressor PTEN is associated with increased cancer aggressiveness, decreased tumor immune infiltration, and resistance…”
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The dynamics of diverse segmental amplifications in populations of Saccharomyces cerevisiae adapting to strong selection by Payen, Celia, Di Rienzi, Sara C, Ong, Giang T, Pogachar, Jamie L, Sanchez, Joseph C, Sunshine, Anna B, Raghuraman, M K, Brewer, Bonita J, Dunham, Maitreya J

“…Population adaptation to strong selection can occur through the sequential or parallel accumulation of competing beneficial mutations. The dynamics, diversity,…”
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Ultra High-plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles by Bonnett, Shilah A, Rosenbloom, Alyssa B, Ong, Giang T, Conner, Mark, Rininger, Aric B E, Newhouse, Daniel, New, Felicia, Phan, Chi Q, Ilcisin, Saskia, Sato, Hiromi, Lyssand, John S, Geiss, Gary, Beechem, Joseph M

“…A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of…”
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Abstract 2342: Digital gene expression of up to 96 targets in 96 samples for cell line screening with nCounter® PlexSet by Ong, Giang T., Merritt, Chris, Kharkia, Anisha, Webster, Philippa

“…Abstract Cell line screening studies require highly efficient protocols for studying many samples in parallel. We have developed a lyse-and-go protocol for…”
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The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects: e1002155 by Sunshine, Anna B, Payen, Celia, Ong, Giang T, Liachko, Ivan, Tan, Kean Ming, Dunham, Maitreya J

“…Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell's proliferative ability, or cellular fitness, has…”
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