Search Results - "Ong, Eugenia Z"

Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness by Manokaran, Gayathri, Finol, Esteban, Wang, Chunling, Gunaratne, Jayantha, Bahl, Justin, Ong, Eugenia Z., Tan, Hwee Cheng, Sessions, October M., Ward, Alex M., Gubler, Duane J., Harris, Eva, Garcia-Blanco, Mariano A., Ooi, Eng Eong

“…The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential…”
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Adverse effects following anti-COVID-19 vaccination with mRNA-based BNT162b2 are alleviated by altering the route of administration and correlate with baseline enrichment of T and NK cell genes by Syenina, Ayesa, Gan, Esther S, Toh, Justin Z N, de Alwis, Ruklanthi, Lin, Lowell Z, Tham, Christine Y L, Yee, Jia Xin, Leong, Yan Shan, Sam, Huizhen, Cheong, Charlene, Teh, Yii Ean, Wee, Ian L E, Ng, Dorothy H L, Chan, Kuan Rong, Sim, Jean X Y, Kalimuddin, Shirin, Ong, Eugenia Z, Low, Jenny G, Ooi, Eng Eong

“…Ensuring high vaccination and even booster vaccination coverage is critical in preventing severe Coronavirus Disease 2019 (COVID-19). Among the various…”
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Viral Manipulation of Host Inhibitory Receptor Signaling for Immune Evasion by Ong, Eugenia Z, Chan, Kuan Rong, Ooi, Eng Eong

“…Eugenia Z. Ong Affiliation: Experimental Therapeutics Centre, Agency for Science, Technology, and Research, Singapore Kuan Rong Chan Affiliation: Programme in…”
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Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue by Chan, Kuan Rong, Ong, Eugenia Z., Tan, Hwee Cheng, Zhang, Summer Li-Xin, Zhang, Qian, Tang, Kin Fai, Kaliaperumal, Nivashini, Pei Chiew Lim, Angeline, Hibberd, Martin L., Chan, Soh Ha, Connolly, John E., Krishnan, Manoj N., Lok, Shee Mei, Hanson, Brendon J., Lin, Chao-Nan, Ooi, Eng Eong

“…Viruses must evade the host innate defenses for replication and dengue is no exception. During secondary infection with a heterologous dengue virus (DENV)…”
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An experimental medicine decipher of a minimum correlate of cellular immunity: Study protocol for a double-blind randomized controlled trial by Kalimuddin, Shirin, Chan, Yvonne F Z, Sessions, October M, Chan, Kuan Rong, Ong, Eugenia Z, Low, Jenny G, Bertoletti, Antonio, Ooi, Eng Eong

“…Vaccination induces an adaptive immune response that protects against infectious diseases. A defined magnitude of adaptive immune response that correlates with…”
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Neutralization of antibody-enhanced dengue infection by VIS513, a pan serotype reactive monoclonal antibody targeting domain III of the dengue E protein by Budigi, Yadunanda, Ong, Eugenia Z, Robinson, Luke N, Ong, Li Ching, Rowley, Kirk J, Winnett, Alexander, Tan, Hwee Cheng, Hobbie, Sven, Shriver, Zachary, Babcock, Gregory J, Alonso, Sylvie, Ooi, Eng Eong

“…Dengue virus (DENV) infection imposes enormous health and economic burden worldwide with no approved treatment. Several small molecules, including lovastatin,…”
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A fast-growing dengue virus mutant reveals a dual role of STING in response to infection by Ng, Wy Ching, Kwek, Swee Sen, Sun, Bo, Yousefi, Meisam, Ong, Eugenia Z, Tan, Hwee Cheng, Puschnik, Andreas S, Chan, Kuan Rong, Ooi, Yaw Shin, Ooi, Eng Eong

“…The four dengue viruses (DENVs) have evolved multiple mechanisms to ensure its survival. Among these mechanisms is the ability to regulate its replication…”
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A systematic approach to the development of a safe live attenuated Zika vaccine by Kwek, Swee Sen, Watanabe, Satoru, Chan, Kuan Rong, Ong, Eugenia Z., Tan, Hwee Cheng, Ng, Wy Ching, Nguyen, Mien T. X., Gan, Esther S., Zhang, Summer L., Chan, Kitti W. K., Tan, Jun Hao, Sessions, October M., Manuel, Menchie, Pompon, Julien, Chua, Camillus, Hazirah, Sharifah, Tryggvason, Karl, Vasudevan, Subhash G., Ooi, Eng Eong

“…Zika virus (ZIKV) is a flavivirus that can cause congenital disease and requires development of an effective long-term preventative strategy. A replicative…”
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Electron transport chain capacity expands yellow fever vaccine immunogenicity by Mok, Darren ZL, Tng, Danny JH, Yee, Jia Xin, Chew, Valerie SY, Tham, Christine YL, Ooi, Justin SG, Tan, Hwee Cheng, Zhang, Summer L, Lin, Lowell Z, Ng, Wy Ching, Jeeva, Lavanya Lakshmi, Murugayee, Ramya, Goh, Kelvin K-K, Lim, Tze-Peng, Cui, Liang, Cheung, Yin Bun, Ong, Eugenia Z, Chan, Kuan Rong, Ooi, Eng Eong, Low, Jenny G

“…Vaccination has successfully controlled several infectious diseases although better vaccines remain desirable. Host response to vaccination studies have…”
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A phase I/II randomized, double-blinded, placebo-controlled trial of a self-amplifying Covid-19 mRNA vaccine by Low, Jenny G., de Alwis, Ruklanthi, Chen, Shiwei, Kalimuddin, Shirin, Leong, Yan Shan, Mah, Tania Ken Lin, Yuen, Natalene, Tan, Hwee Cheng, Zhang, Summer L., Sim, Jean X. Y., Chan, Yvonne F. Z., Syenina, Ayesa, Yee, Jia Xin, Ong, Eugenia Z., Sekulovich, Rose, Sullivan, Brian B., Lindert, Kelly, Sullivan, Sean M., Chivukula, Pad, Hughes, Steven G., Ooi, Eng Eong

“…Coronavirus disease-19 (Covid-19) pandemic have demonstrated the importantance of vaccines in disease prevention. Self-amplifying mRNA vaccines could be…”
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Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution by Ong, Eugenia Z, Kalimuddin, Shirin, Chia, Wen Chong, Ooi, Sarah H, Koh, Clara WT, Tan, Hwee Cheng, Zhang, Summer L, Low, Jenny G, Ooi, Eng Eong, Chan, Kuan Rong

“…The coronavirus disease-19 (COVID-19) pandemic has cost lives and economic hardships globally. Various studies have found a number of different factors, such…”
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Live vaccine infection burden elicits adaptive humoral and cellular immunity required to prevent Zika virus infection by Yau, Clement, Gan, Esther Shuyi, Kwek, Swee Sen, Tan, Hwee Cheng, Ong, Eugenia Z., Hamis, Noor Zayanah, Rivino, Laura, Chan, Kuan Rong, Watanabe, Satoru, Vasudevan, Subhash G., Ooi, Eng Eong

“…The emergence of Zika virus (ZIKV) as an important cause of congenital and childhood developmental disorders presents another challenge to global health…”
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Therapeutic antibodies as a treatment option for dengue fever by Chan, Kuan Rong, Ong, Eugenia Z, Ooi, Eng Eong

“…Dengue fever is the most prevalent mosquito-borne viral disease globally with about 100 million cases of acute dengue annually. Severe dengue infection can…”
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Immune gene expression analysis indicates the potential of a self-amplifying Covid-19 mRNA vaccine by Ong, Eugenia Z., Yee, Jia Xin, Ooi, Justin S. G., Syenina, Ayesa, de Alwis, Ruklanthi, Chen, Shiwei, Sim, Jean X. Y., Kalimuddin, Shirin, Leong, Yan Shan, Chan, Yvonne F. Z., Sekulovich, Rose, Sullivan, Brian M., Lindert, Kelly, Sullivan, Sean B., Chivukula, Pad, Hughes, Steven G., Low, Jenny G., Ooi, Eng Eong, Chan, Kuan Rong

“…Remarkable potency has been demonstrated for mRNA vaccines in reducing the global burden of the ongoing COVID-19 pandemic. An alternative form of the mRNA…”
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Early T cell and binding antibody responses are associated with COVID-19 RNA vaccine efficacy onset by Kalimuddin, Shirin, Tham, Christine Y L, Qui, Martin, de Alwis, Ruklanthi, Sim, Jean X Y, Lim, Joey M E, Tan, Hwee-Cheng, Syenina, Ayesa, Zhang, Summer L, Le Bert, Nina, Tan, Anthony T, Leong, Yan Shan, Yee, Jia Xin, Ong, Eugenia Z, Ooi, Eng Eong, Bertoletti, Antonio, Low, Jenny G

“…RNA vaccines against coronavirus disease 2019 (COVID-19) have demonstrated ∼95% efficacy in phase III clinical trials. Although complete vaccination consisted…”
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Publisher Correction: Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children by Zhong, Youjia, Kang, Alicia Y. H., Tay, Carina J. X., Li, Hui’ En, Elyana, Nurul, Tan, Chee Wah, Yap, Wee Chee, Lim, Joey M. E., Le Bert, Nina, Chan, Kuan Rong, Ong, Eugenia Z., Low, Jenny G., Shek, Lynette P., Tham, Elizabeth Huiwen, Ooi, Eng Eong

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Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children by Zhong, Youjia, Kang, Alicia Y. H., Tay, Carina J. X., Li, Hui’ En, Elyana, Nurul, Tan, Chee Wah, Yap, Wee Chee, Lim, Joey M. E., Le Bert, Nina, Chan, Kuan Rong, Ong, Eugenia Z., Low, Jenny G., Shek, Lynette P., Tham, Elizabeth Huiwen, Ooi, Eng Eong

“…The paucity of information on longevity of vaccine-induced immune responses and uncertainty of the correlates of protection hinder the development of…”
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Dengue virus compartmentalization during antibody-enhanced infection by Ong, Eugenia Z., Zhang, Summer L., Tan, Hwee Cheng, Gan, Esther S., Chan, Kuan Rong, Ooi, Eng Eong

“…Secondary infection with a heterologous dengue virus (DENV) serotype increases the risk of severe dengue, through a process termed antibody-dependent…”
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Phase 1 Trial of a Therapeutic Anti–Yellow Fever Virus Human Antibody by Low, Jenny G, Ng, Justin H.J, Ong, Eugenia Z, Kalimuddin, Shirin, Wijaya, Limin, Chan, Yvonne F.Z, Ng, Dorothy H.L, Tan, Hwee-Cheng, Baglody, Anjali, Chionh, Yok-Hian, Lee, Debbie C.P, Budigi, Yadunanda, Sasisekharan, Ram, Ooi, Eng-Eong

“…A phase 1a–1b trial of TY014, an IgG1 anti–yellow fever virus monoclonal antibody, did not identify worrisome safety signals. Ten participants were randomly…”
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Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope by Tharakaraman, Kannan, Watanabe, Satoru, Chan, Kuan Rong, Huan, Jia, Subramanian, Vidya, Chionh, Yok Hian, Raguram, Aditya, Quinlan, Devin, McBee, Megan, Ong, Eugenia Z., Gan, Esther S., Tan, Hwee Cheng, Tyagi, Anu, Bhushan, Shashi, Lescar, Julien, Vasudevan, Subhash G., Ooi, Eng Eong, Sasisekharan, Ram

“…Following the recent emergence of Zika virus (ZIKV), many murine and human neutralizing anti-ZIKV antibodies have been reported. Given the risk of virus escape…”
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