Search Results - "Ong, Esther"

Deep learning for de-convolution of Smad2 versus Smad3 binding sites by Ng, Jeremy W.K, Ong, Esther H.Q, Tucker-Kellogg, Lisa, Tucker-Kellogg, Greg

“…The transforming growth factor beta-1 (TGF [beta]-1) cytokine exerts both pro-tumor and anti-tumor effects in carcinogenesis. An increasing body of literature…”
Get full text

Direct Patterning of Zinc Sulfide on a Sub-10 Nanometer Scale via Electron Beam Lithography by Saifullah, Mohammad S. M, Asbahi, Mohamed, Binti-Kamran Kiyani, Maryam, Tripathy, Sudhiranjan, Ong, Esther A. H, Ibn Saifullah, Asadullah, Tan, Hui Ru, Dutta, Tanmay, Ganesan, Ramakrishnan, Valiyaveettil, Suresh, Chong, Karen S. L

“…Nanostructures of metal sulfides are conventionally prepared via chemical techniques and patterned using self-assembly. This poses a considerable amount of…”
Get full text

Room-Temperature Patterning of Nanoscale MoS2 under an Electron Beam by Saifullah, Mohammad S. M, Asbahi, Mohamed, Binti-Kamran Kiyani, Maryam, Liow, Sing Shy, Bin Dolmanan, Surani, Yong, Anna Marie, Ong, Esther A. H, Ibn Saifullah, Asadullah, Tan, Hui Ru, Dwivedi, Neeraj, Dutta, Tanmay, Ganesan, Ramakrishnan, Valiyaveettil, Suresh, Chong, Karen S. L, Tripathy, Sudhiranjan

“…Molybdenum disulfide (MoS2) is traditionally grown at a high temperature and subsequently patterned to study its electronic properties or make devices. This…”
Get full text

Designing a leucine‐rich antibacterial nonapeptide with potent activity against mupirocin‐resistant MRSA via a structure–activity relationship study by Ang, Qi An, Arfan, Giovinna, Ong, Chu Yang Fann, Ng, Fui Mee, Ong, Esther H. Q., Chia, Cheng San Brian

“…Staphylococcus aureus is the main aetiological agent responsible for the majority of human skin infections. Of particular concern is the methicillin‐resistant…”
Get full text

An industry perspective approach and control strategy for implementation of ready-to-use cells in bioassays: survey outcome and recommendations by White, John R, Ahmed, Sammina, Amstrup, Jan, Bennington, Petra, Cheng, Zhijie Jey, Day, Peter, Haenssen, Keneshia K, Kozminsky-Atias, Adi, Martinez, Eva, Ong, Esther Hq, Qahwash, Isam, Stokes, Elaine Se, Wang, Jenny

“…The BioPhorum Development Group is an industry collaboration enabling the sharing of common practices for the development of biopharmaceuticals. Bioassays are…”
Get full text

Design, synthesis and biological evaluation of FLT3 covalent inhibitors with a resorcylic acid core by Xu, Jin, Ong, Esther H.Q., Hill, Jeffrey, Chen, Anqi, Chai, Christina L.L.

“…[Display omitted] A series of simplified ring-opened resorcylic acid lactone (RAL) derivatives were conveniently synthesized to target FLT3 and its mutants…”
Get full text

A Mixed-Methods Study on Religiosity, Pandemic Beliefs, and Psychological Well-Being During the COVID-19 Pandemic in Malaysia by Ting, Rachel Sing-Kiat, Goh, Pei Hwa, Ong, Esther Zhen-Mei

“…This paper examines the association between religious identity, religiosity (internal vs external), and psychological well-being during the COVID-19 pandemic…”
Get full text

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors by Kwiatkowski, Jacek, Liu, Boping, Tee, Doris Hui Ying, Chen, Guoying, Ahmad, Nur Huda Binte, Wong, Yun Xuan, Poh, Zhi Ying, Ang, Shi Hua, Tan, Eldwin Sum Wai, Ong, Esther HQ, Nurul Dinie, Poulsen, Anders, Pendharkar, Vishal, Sangthongpitag, Kanda, Lee, May Ann, Sepramaniam, Sugunavathi, Ho, Soo Yei, Cherian, Joseph, Hill, Jeffrey, Keller, Thomas H, Hung, Alvin W

“…Protein kinase C iota (PKC-ι) is an atypical kinase implicated in the promotion of different cancer types. A biochemical screen of a fragment library has…”
Get full text

Structure–Activity Relationship Studies of Mitogen Activated Protein Kinase Interacting Kinase (MNK) 1 and 2 and BCR-ABL1 Inhibitors Targeting Chronic Myeloid Leukemic Cells by Cherian, Joseph, Nacro, Kassoum, Poh, Zhi Ying, Guo, Samantha, Jeyaraj, Duraiswamy A, Wong, Yun Xuan, Ho, Melvyn, Yang, Hai Yan, Joy, Joma Kanikadu, Kwek, Zekui Perlyn, Liu, Boping, Wee, John Liang Kuan, Ong, Esther HQ, Choong, Meng Ling, Poulsen, Anders, Lee, May Ann, Pendharkar, Vishal, Ding, Li Jun, Manoharan, Vithya, Chew, Yun Shan, Sangthongpitag, Kanda, Lim, Sharon, Ong, S. Tiong, Hill, Jeffrey, Keller, Thomas H

“…Clinically used BCR-ABL1 inhibitors for the treatment of chronic myeloid leukemia do not eliminate leukemic stem cells (LSC). It has been shown that MNK1 and 2…”
Get full text

Fragment-based Discovery of a Small-Molecule Protein Kinase C‑iota Inhibitor Binding Post-kinase Domain Residues by Kwiatkowski, Jacek, Baburajendran, Nithya, Poulsen, Anders, Liu, Boping, Tee, Doris Hui Ying, Wong, Yun Xuan, Poh, Zhi Ying, Ong, Esther HQ, Dinie, Nurul, Cherian, Joseph, Jansson, Anna Elisabet, Hill, Jeffrey, Keller, Thomas H, Hung, Alvin W

“…The atypical protein kinase C-iota (PKC-ι) enzyme is implicated in various cancers and has been put forward as an attractive target for developing anticancer…”
Get full text

Rational Design of Resorcylic Acid Lactone Analogues as Covalent MNK1/2 Kinase Inhibitors by Tuning the Reactivity of an Enamide Michael Acceptor by Xu, Jin, Chen, Anqi, Joy, Joma, Xavier, Vanessa Joanne, Ong, Esther H. Q., Hill, Jeffrey, Chai, Christina L. L.

“…Recent biological and computational advances in drug design have led to renewed interest in targeted covalent inhibition as an efficient and practical approach…”
Get full text

Room-Temperature Patterning of Nanoscale MoS 2 under an Electron Beam by Saifullah, Mohammad S M, Asbahi, Mohamed, Binti-Kamran Kiyani, Maryam, Liow, Sing Shy, Bin Dolmanan, Surani, Yong, Anna Marie, Ong, Esther A H, Ibn Saifullah, Asadullah, Tan, Hui Ru, Dwivedi, Neeraj, Dutta, Tanmay, Ganesan, Ramakrishnan, Valiyaveettil, Suresh, Chong, Karen S L, Tripathy, Sudhiranjan

“…Molybdenum disulfide (MoS ) is traditionally grown at a high temperature and subsequently patterned to study its electronic properties or make devices. This…”
Get full text

3-Deazaneplanocin A and Neplanocin A Analogues and Their Effects on Apoptotic Cell Death by Tam, Eric K. W., Nguyen, Tuan Minh, Lim, Cheryl Z. H., Lee, Puay Leng, Li, Zhimei, Jiang, Xia, Santhanakrishnan, Sridhar, Tan, Tiong Wei, Goh, Yi Ling, Wong, Sze Yue, Yang, Haiyan, Ong, Esther H. Q., Hill, Jeffrey, Yu, Qiang, Chai, Christina L. L.

“…3‐Deazaneplanocin A (DzNep) is a potential epigenetic drug for the treatment of various cancers. DzNep has been reported to deplete histone methylations,…”
Get full text

An FDA-Drug Library Screen for Compounds with Bioactivities against Meticillin-Resistant Staphylococcus aureus (MRSA) by Lau, Qiu Ying, Tan, Yoke Yan Fion, Goh, Vanessa Chai Yin, Lee, David Jing Qin, Ng, Fui Mee, Ong, Esther H Q, Hill, Jeffrey, Chia, Cheng San Brian

“…The lack of new antibacterial drugs entering the market and their misuse have resulted in the emergence of drug-resistant bacteria, posing a major health…”
Get full text

Screening for a Potent Antibacterial Peptide to Treat Mupirocin-Resistant MRSA Skin Infections by Ng, Siew Mei Samantha, Ching, Hui Si Vivian, Xu, GuiFang, Ng, Fui Mee, Ong, Esther H. Q., Lau, Qiu Ying, Jureen, Roland, Hill, Jeffrey, Chia, C. S. Brian

“…Mupirocin is the first-line topical antibacterial drug for treating skin infections caused primarily by meticillin-resistant Staphylococcus aureus (MRSA). Its…”
Get full text

Elective gastrostomy, nutritional status and quality of life in advanced head and neck cancer patients receiving chemoradiotherapy by Morton, Randall P., Crowder, Victoria L., Mawdsley, Robert, Ong, Esther, Izzard, Mark

“…Background:  Chemoradiotherapy for treatment of advanced head and neck cancer (HNC) is used to achieve organ preservation without compromising survival…”
Get full text

Correction to “Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3” by Huang, Chuhui, Liew, Si Si, Lin, Grace R, Poulsen, Anders, Ang, Melgious J. Y, Chia, Brian C. S, Chew, Sin Yin, Kwek, Zekui P, Wee, John L. K, Ong, Esther H, Retna, Priya, Baburajendran, Nithya, Li, Rong, Yu, Weixuan, Koh-Stenta, Xiaoying, Ngo, Anna, Manesh, Sravanthy, Fulwood, Justina, Ke, Zhiyuan, Chung, Hwa Hwa, Sepramaniam, Sugunavathi, Chew, Xin Hui, Dinie, Nurul, Lee, May Ann, Chew, Yun Shan, Low, Choon Bing, Pendharkar, Vishal, Manoharan, Vithya, Vuddagiri, Susmitha, Sangthongpitag, Kanda, Joy, Joma, Matter, Alex, Hill, Jeffrey, Keller, Thomas H, Foo, Klement

“…[This corrects the article DOI: 10.1021/acsmedchemlett.9b00170.]…”
Get full text

Discovery of Irreversible Inhibitors Targeting Histone Methyltransferase, SMYD3 by Huang, Chuhui, Liew, Si Si, Lin, Grace R, Poulsen, Anders, Ang, Melgious J. Y, Chia, Brian C. S, Chew, Sin Yin, Kwek, Zekui P, Wee, John L. K, Ong, Esther H, Retna, Priya, Baburajendran, Nithya, Li, Rong, Yu, Weixuan, Koh-Stenta, Xiaoying, Ngo, Anna, Manesh, Sravanthy, Fulwood, Justina, Ke, Zhiyuan, Chung, Hwa Hwa, Sepramaniam, Sugunavathi, Chew, Xin Hui, Dinie, Nurul, Lee, May Ann, Chew, Yun Shan, Low, Choon Bing, Pendharkar, Vishal, Manoharan, Vithya, Vuddagiri, Susmitha, Sangthongpitag, Kanda, Joy, Joma, Matter, Alex, Hill, Jeffrey, Keller, Thomas H, Foo, Klement

“…SMYD3 is a histone methyltransferase that regulates gene transcription, and its overexpression is associated with multiple human cancers. A novel class of…”
Get full text

An ecological model of experienced stigma during the COVID-19 pandemic: A qualitative study in Malaysia by Zay Hta, May Kyi, Ting, Rachel Sing-Kiat, Ong, Esther Zhen Mei, Jones, Liz

“…In this paper, we adopted an ecological model and relational cognition framework to decolonize pandemic stigma in a non-WEIRD society. We reconstructed the…”
Get full text

Optimization of Selective Mitogen-Activated Protein Kinase Interacting Kinases 1 and 2 Inhibitors for the Treatment of Blast Crisis Leukemia by Yang, Haiyan, Chennamaneni, Lohitha Rao, Ho, Melvyn Wai Tuck, Ang, Shi Hua, Tan, Eldwin Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Yeap, Yoon Sheng, Liu, Boping, Ong, Esther Hq, Joy, Joma Kanikadu, Wee, John Liang Kuan, Kwek, Perlyn, Retna, Priya, Dinie, Nurul, Nguyen, Thuy Thi Hanh, Tai, Shi Jing, Manoharan, Vithya, Pendharkar, Vishal, Low, Choon Bing, Chew, Yun Shan, Vuddagiri, Susmitha, Sangthongpitag, Kanda, Choong, Meng Ling, Lee, May Ann, Kannan, Srinivasaraghavan, Verma, Chandra S, Poulsen, Anders, Lim, Sharon, Chuah, Charles, Ong, Tiong Sin, Hill, Jeffrey, Matter, Alex, Nacro, Kassoum

“…Chronic myeloid leukemia (CML) is a myeloproliferative disease caused by bcr-abl1, a constitutively active tyrosine kinase fusion gene responsible for an…”
Get full text