Search Results - "Ong, C. N"

Deformability study of breast cancer cells using microfluidics by Hou, H. W., Li, Q. S., Lee, G. Y. H., Kumar, A. P., Ong, C. N., Lim, C. T.

“…Cell deformability is an important biomarker which can be used to distinguish between healthy and diseased cells. In this study, microfluidics is used to probe…”
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Clarifying the absence of evidence regarding human health risks to microplastic particles in drinking-water: High quality robust data wanted by Gouin, T., Cunliffe, D., De France, J., Fawell, J., Jarvis, P., Koelmans, A.A., Marsden, P., Testai, E.E., Asami, M., Bevan, R., Carrier, R., Cotruvo, J., Eckhardt, A., Ong, C.N.

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A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus by Ng, D. P. K., Salim, A., Liu, Y., Zou, L., Xu, F. G., Huang, S., Leong, H., Ong, C. N.

“…Aims/hypothesis We carried out a urinary metabolomic study to gain insight into low estimated GFR (eGFR) in patients with non-proteinuric type 2 diabetes…”
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Plasma carotenoids and risk of acute myocardial infarction in the Singapore Chinese Health Study by Koh, W.-P, Yuan, J.-M, Wang, R, Lee, Y.-P, Lee, B.-L, Yu, M.C, Ong, C.-N

“…Abstract Background and aim Modification of low-density lipoprotein due to oxidative stress is essential in the development of coronary atherosclerosis. Data…”
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A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress by Huang, Q, Wu, Y-T, Tan, H-L, Ong, C-N, Shen, H-M

“…Under oxidative stress, poly(ADP-ribose) polymerase-1 (PARP-1) is activated and contributes to necrotic cell death through ATP depletion. On the other hand,…”
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Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway by Huang, Q, Shen, H-M, Ong, C-N

“…Enhanced cell migration is one of the underlying mechanisms in cancer invasion and metastasis. Therefore, inhibition of cell migration is considered to be an…”
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Hypericin photoactivation triggers down-regulation of matrix metalloproteinase-9 expression in well-differentiated human nasopharyngeal cancer cells by Du, H. -Y, Olivo, M, Mahendran, R, Huang, Q, Shen, H. -M, Ong, C. -N, Bay, B. -H

“…Recently, we have shown that hypericin-mediated photodynamic therapy (PDT) is a promising modality for the treatment of nasopharyngeal cancer (NPC). The…”
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Reduced mitochondrial coenzyme Q10 levels in HepG2 cells treated with high-dose simvastatin: A possible role in statin-induced hepatotoxicity? by Tavintharan, S., Ong, C.N., Jeyaseelan, K., Sivakumar, M., Lim, S.C., Sum, C.F.

“…Lowering of low-density lipoprotein cholesterol is well achieved by 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins). Statins…”
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Oxidative burden in prediabetic and diabetic individuals: evidence from plasma coenzyme Q10 by Lim, S. C., Tan, H. H., Goh, S. K., Subramaniam, T., Sum, C. F., Tan, I. K., Lee, B. L., Ong, C. N.

“…Aim  Individuals with diabetes and prediabetes are at risk of vascular injury. However, the exact mechanisms are unclear. The mitochondria mobile electron…”
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Critical Role of Reactive Oxygen Species and Mitochondrial Permeability Transition in Microcystin-Induced Rapid Apoptosis in Rat Hepatocytes by Ding, Wen-Xing, Shen, Han-Ming, Ong, Choon-Nam

“…Microcystin-LR (M-LR) is a specific hepatotoxin. At present, the exact toxic mechanism of its action remains unclear though apoptosis is believed to be…”
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Titanium dioxide nanomaterials cause endothelial cell leakiness by disrupting the homophilic interaction of VE–cadherin by Setyawati, M.I., Tay, C.Y., Chia, S.L., Goh, S.L., Fang, W., Neo, M.J., Chong, H.C., Tan, S.M., Loo, S.C.J., Ng, K.W., Xie, J.P., Ong, C.N., Tan, N.S., Leong, D.T.

“…The use of nanomaterials has raised safety concerns, as their small size facilitates accumulation in and interaction with biological tissues. Here we show that…”
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AFM indentation study of breast cancer cells by Li, Q.S., Lee, G.Y.H., Ong, C.N., Lim, C.T.

“…Mechanical properties of individual living cells are known to be closely related to the health and function of the human body. Here, atomic force microscopy…”
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Increased uptake of divalent metals lead and cadmium into the brain after kainite-induced neuronal injury by ONE, W. Y, HE, X, CHUA, L. H, ONG, C. N

“…An increase in iron level, number of iron positive cells and ferritin expression has been observed in the rat hippocampus after neuronal injury induced by the…”
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Signaling pathways from membrane lipid rafts to JNK1 activation in reactive nitrogen species-induced non-apoptotic cell death by Wu, Y-T, Zhang, S, Kim, Y-S, Tan, H-L, Whiteman, M, Ong, C-N, Liu, Z-G, Ichijo, H, Shen, H-M

“…At present, the signaling pathways controlling reactive nitrogen species (RNS)-induced non-apoptotic cell death are relatively less understood. In this work,…”
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CRITICAL ROLE OF REACTIVE OXYGEN SPECIES FORMATION IN MICROCYSTIN-INDUCED CYTOSKELETON DISRUPTION IN PRIMARY CULTURED HEPATOCYTES by Ding, Wen-Xing, Shen, Han-Ming, Ong, Choon-Nam

“…Cyanobacteria (blue-green algae)-contaminated water is a worldwide public health problem. Microcystins are a group of liver-specific toxins generated by…”
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beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells by Rose, P, Whiteman, M, Huang, S H, Halliwell, B, Ong, C N

“…beta-Phenylethyl isothiocyanate (PEITC) is a promising chemoprotective compound that is routinely consumed in the diet as its glucosinolate precursor. Previous…”
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Biological monitoring of kidney function among workers occupationally exposed to trichloroethylene by Green, T, Dow, J, Ong, C N, Ng, V, Ong, H Y, Zhuang, Z X, Yang, X F, Bloemen, L

“…Aims: To investigate the nephrotoxic potential of trichloroethylene in a currently exposed population using sensitive urinary markers of kidney toxicity…”
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Gold Nanoparticles Induce Oxidative Damage in Lung Fibroblasts In Vitro by Li, J. J., Zou, L., Hartono, D., Ong, C.-N., Bay, B.-H., Lanry Yung, L.-Y.

“…Evaluation of the health risks associated with the use of nanometer‐sized particles constitutes an important research field. Here, the effect of gold…”
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Homocysteine, folate, vitamin B12, and cardiovascular risk in Indians, Malays, and Chinese in Singapore by Hughes, Kenneth, Ong, Choon-Nam

“…OBJECTIVE To examine the hypothesis that the higher rates of coronary heart disease (CHD) in Indians (South Asians) compared with Malays and Chinese is partly…”
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Vitamins, selenium, iron, and coronary heart disease risk in Indians, Malays, and Chinese in Singapore by Hughes, K, Ong, C N

“…STUDY OBJECTIVE: To examine the hypothesis that the higher rates of coronary heart disease (CHD) in Indians (South Asians) compared with Malays and Chinese is…”
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