Search Results - "Onega Mayca"

Hippocampal Neuroinflammation, Functional Connectivity, and Depressive Symptoms in Multiple Sclerosis by Colasanti, Alessandro, Guo, Qi, Giannetti, Paolo, Wall, Matthew B, Newbould, Rexford D, Bishop, Courtney, Onega, Mayca, Nicholas, Richard, Ciccarelli, Olga, Muraro, Paolo A, Malik, Omar, Owen, David R, Young, Allan H, Gunn, Roger N, Piccini, Paola, Matthews, Paul M, Rabiner, Eugenii A

“…ABSTRACT Background Depression, a condition commonly comorbid with multiple sclerosis (MS), is associated more generally with elevated inflammatory markers and…”
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Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study) by Lukey, Pauline T., Coello, Christopher, Gunn, Roger, Parker, Christine, Wilson, Frederick J., Saleem, Azeem, Garman, Nadia, Costa, Maria, Kendrick, Stuart, Onega, Mayca, Kang’ombe, Arthur R., Listanco, Allan, Davies, James, Ramada-Magalhaes, Joaquim, Moz, Sara, Fahy, William A., Maher, Toby M., Jenkins, Gisli, Passchier, Jan, Marshall, Richard P.

“…Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis through activation of transforming growth factor beta (TGFβ). This study…”
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Preclinical evaluation of [18F]FB-A20FMDV2 as a selective marker for measuring αVβ6 integrin occupancy using positron emission tomography in rodent lung by Onega, Mayca, Parker, Christine A., Coello, Christopher, Rizzo, Gaia, Keat, Nicholas, Ramada-Magalhaes, Joaquim, Moz, Sara, Tang, Sac-Pham, Plisson, Christophe, Wells, Lisa, Ashworth, Sharon, Slack, Robert J., Vitulli, Giovanni, Wilson, Frederick J., Gunn, Roger, Lukey, Pauline T., Passchier, Jan

“…Purpose Integrin α v β 6 belongs to the RGD subset of the integrin family, and its expression levels are a prognostic and theranostic factor in some types of…”
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An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging by Onega, Mayca, Domarkas, Juozas, Deng, Hai, Schweiger, Lutz F, Smith, Timothy A D, Welch, Andrew E, Plisson, Christophe, Gee, Antony D, O'Hagan, David

“…An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel…”
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A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18F-FB-A20FMDV2 for Imaging the Integrin αvβ6 by Keat, Nicholas, Kenny, Julia, Chen Keguan, Onega Mayca, Garman, Nadia, Slack, Robert J, Parker, Christine A, Thomas, Lumbers R, Hallett, Will, Saleem Azeem, Passchier, Jan, Lukey, Pauline T

“…The αvβ6 integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid αvβ6-binding peptide, derived from the foot and mouth…”
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Quantification of the specific translocator protein signal of 18F-PBR111 in healthy humans: a genetic polymorphism effect on in vivo binding by Guo, Qi, Colasanti, Alessandro, Owen, David R, Onega, Mayca, Kamalakaran, Aruloly, Bennacef, Idriss, Matthews, Paul M, Rabiner, Eugenii A, Turkheimer, Federico E, Gunn, Roger N

“…PET is used to image active inflammatory processes by targeting the translocator protein (TSPO). In vitro, second-generation TSPO radioligands, such as PBR111,…”
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In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with (18)F-PBR111 PET by Colasanti, Alessandro, Guo, Qi, Muhlert, Nils, Giannetti, Paolo, Onega, Mayca, Newbould, Rexford D, Ciccarelli, Olga, Rison, Stuart, Thomas, Charlotte, Nicholas, Richard, Muraro, Paolo A, Malik, Omar, Owen, David R, Piccini, Paola, Gunn, Roger N, Rabiner, Eugenii A, Matthews, Paul M

“…PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients with multiple sclerosis (MS) primarily reflects activated microglia…”
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Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus by Huang, Sheng, Zhao, Yudong, Qin, Zhiwei, Wang, Xiaoling, Onega, Mayca, Chen, Li, He, Jing, Yu, Yi, Deng, Hai

“…Holomycin is a dithiolopyrrolone antibiotic natural product produced by Streptomyces clavuligerus, ATCC 27064. This paper reports on the identification of a…”
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A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables “Last‐Step” 18 F Fluorination of a RGD Peptide under Ambient Aqueous Conditions by Thompson, Stephen, Zhang, Qingzhi, Onega, Mayca, McMahon, Stephen, Fleming, Ian, Ashworth, Sharon, Naismith, James H., Passchier, Jan, O'Hagan, David

“…A strategy for last‐step 18 F fluorination of bioconjugated peptides is reported that exploits an “Achilles heel” in the substrate specificity of the…”
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A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables "Last-Step" 18FFluorination of a RGD Peptide under Ambient Aqueous Conditions by Thompson, Stephen, Zhang, Qingzhi, Onega, Mayca, McMahon, Stephen, Fleming, Ian, Ashworth, Sharon, Naismith, James H, Passchier, Jan, O'Hagan, David

“…A strategy for last-step 18Ffluorination of bioconjugated peptides is reported that exploits an "Achilles heel" in the substrate specificity of the fluorinase…”
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A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables "Last-Step" super(18)FFluorination of a RGD Peptide under Ambient Aqueous Conditions by Thompson, Stephen, Zhang, Qingzhi, Onega, Mayca, McMahon, Stephen, Fleming, Ian, Ashworth, Sharon, Naismith, James H, Passchier, Jan, O'Hagan, David

“…A strategy for last-step super(18)Ffluorination of bioconjugated peptides is reported that exploits an "Achilles heel" in the substrate specificity of the…”
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A Localized Tolerance in the Substrate Specificity of the Fluorinase Enzyme enables "Last-Step" 18F Fluorination of a RGD Peptide under Ambient Aqueous Conditions by Thompson, Stephen, Zhang, Qingzhi, Onega, Mayca, McMahon, Stephen, Fleming, Ian, Ashworth, Sharon, Naismith, James H., Passchier, Jan, O'Hagan, David

“…A strategy for last‐step 18F fluorination of bioconjugated peptides is reported that exploits an “Achilles heel” in the substrate specificity of the fluorinase…”
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Tumour imaging by Positron Emission Tomography using fluorinase generated 5-[18 F]fluoro-5-deoxyribose as a novel tracer by Dall'Angelo, Sergio, Bandaranayaka, Nouchali, Windhorst, Albert D, Vugts, Danielle J, van der Born, Dion, Onega, Mayca, Schweiger, Lutz F, Zanda, Matteo, O'Hagan, David

“…Abstract Introduction 5-[18 F]Fluoro-5-deoxyribose ([18 F]FDR) 3 was prepared as a novel monosaccharide radiotracer in a two-step synthesis using the…”
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Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling by Deng, Hai, Cobb, Steven L, Gee, Antony D, Lockhart, Andrew, Martarello, Laurent, McGlinchey, Ryan P, O'Hagan, David, Onega, Mayca

“…The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5'-fluoro-5'-deoxyadenosine,…”
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Quantification of the Specific Translocator Protein Signal of ^sup 18^F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding by Guo, Qi, Colasanti, Alessandro, Owen, David R, Onega, Mayca, Kamalakaran, Aruloly, Bennacef, Idriss, Matthews, Paul M, Rabiner, Eugenii A, Turkheimer, Federico E, Gunn, Roger N

“…PET is used to image active inflammatory processes by targeting the translocator protein (TSPO). In vitro, second-generation TSPO radioligands, such as PBR111,…”
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Quantification of the Specific Translocator Protein Signal of 18 F-PBR111 in Healthy Humans: A Genetic Polymorphism Effect on In Vivo Binding by Guo, Qi, Colasanti, Alessandro, Owen, David R., Onega, Mayca, Kamalakaran, Aruloly, Bennacef, Idriss, Matthews, Paul M., Rabiner, Eugenii A., Turkheimer, Federico E., Gunn, Roger N.

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A Microdose PET Study of the Safety, Immunogenicity, Biodistribution, and Radiation Dosimetry of 18 F-FB-A20FMDV2 for Imaging the Integrin α v β 6 by Keat, Nicholas, Kenny, Julia, Chen, Keguan, Onega, Mayca, Garman, Nadia, Slack, Robert J, Parker, Christine A, Lumbers, R Thomas, Hallett, Will, Saleem, Azeem, Passchier, Jan, Lukey, Pauline T

“…The α β integrin is involved in the pathogenesis of cancer and fibrosis. A radiolabeled 20-amino-acid α β -binding peptide, derived from the foot and mouth…”
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In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with 18 F-PBR111 PET by Colasanti, Alessandro, Guo, Qi, Muhlert, Nils, Giannetti, Paolo, Onega, Mayca, Newbould, Rexford D., Ciccarelli, Olga, Rison, Stuart, Thomas, Charlotte, Nicholas, Richard, Muraro, Paolo A., Malik, Omar, Owen, David R., Piccini, Paola, Gunn, Roger N., Rabiner, Eugenii A., Matthews, Paul M.

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In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with ^sup 18^F-PBR111 PET by Colasanti, Alessandro, Guo, Qi, Muhlert, Nils, Giannetti, Paolo, Onega, Mayca, Newbould, Rexford D, Ciccarelli, Olga, Rison, Stuart, Thomas, Charlotte, Nicholas, Richard, Muraro, Paolo A, Malik, Omar, Owen, David R, Piccini, Paola, Gunn, Roger N, Rabiner, Eugenii A, Matthews, Paul M

“…PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients with multiple sclerosis (MS) primarily reflects activated microglia…”
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In Vivo Assessment of Brain White Matter Inflammation in Multiple Sclerosis with sigma up 18 Theta -PBR111 PET by Colasanti, Alessandro, Guo, Qi, Muhlert, Nils, Giannetti, Paolo, Onega, Mayca, Newbould, Rexford D, Ciccarelli, Olga, Rison, Stuart, Thomas, Charlotte, Nicholas, Richard, Muraro, Paolo A, Malik, Omar, Owen, David R, Piccini, Paola, Gunn, Roger N, Rabiner, Eugenii A, Matthews, Paul M

“…PET radioligand binding to the 18-kD translocator protein (TSPO) in the brains of patients with multiple sclerosis (MS) primarily reflects activated microglia…”
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