Search Results - "Ondrus, Janine"

Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC) by Zhang, Zhuming, Connolly, Peter J, Lim, Heng Keang, Pande, Vineet, Meerpoel, Lieven, Teleha, Christopher, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy, Luistro, Leopoldo, Packman, Kathryn, Bischoff, James R, Ibrahim, Salam, Parrett, Christopher, Chong, Yolanda, Gottardis, Marco M, Bignan, Gilles

“…Persistent androgen receptor (AR) activation drives therapeutic resistance to second-generation AR pathway inhibitors and contributes to the progression of…”
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Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer by Branch, Jonathan R, Bush, Tammy L, Pande, Vineet, Connolly, Peter J, Zhang, Zhuming, Hickson, Ian, Ondrus, Janine, Jaensch, Steffen, Bischoff, James R, Habineza, Georges, Van Hecke, Geert, Meerpoel, Lieven, Packman, Kathryn, Parrett, Christopher J, Chong, Yolanda T, Gottardis, Marco M, Bignan, Gilles

“…Numerous mechanisms of resistance arise in response to treatment with second-generation androgen receptor (AR) pathway inhibitors in metastatic…”
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Abstract 2179: Antitumor activity of JNJ-63576253 (TRC253), a small molecule antagonist of F877L mutant and wild-type androgen receptor by Bush, Tammy L., Ndikuyeze, Georges Habineza, Bignan, Gilles, Branch, Jonathan, Ondrus, Janine, Shi, Yifan, Luistro, Leopoldo, Hastings, James, Erhardt, Joseph, Hickson, Ian, Patel, Shefali, Connolly, Peter, Zhang, Zhuming, Bischoff, James, Rupnow, Brent, Gottardis, Marco, Packman, Kathryn

“…Abstract Androgen receptor (AR) antagonists have transformed prostate cancer patient care by targeting a key nodal point in tumor cell signaling. However,…”
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Spirocyclic Thiohydantoin Antagonists of F877L and Wild-Type Androgen Receptor for Castration-Resistant Prostate Cancer by Zhang, Zhuming, Connolly, Peter J, Trabalón Escolar, Luis, Rocaboy, Christian, Pande, Vineet, Meerpoel, Lieven, Lim, Heng-Keang, Branch, Jonathan R, Ondrus, Janine, Hickson, Ian, Bush, Tammy L, Bischoff, James R, Bignan, Gilles

“…Androgen receptor (AR) transcriptional reactivation plays a key role in the development and progression of lethal castration-resistant prostate cancer (CRPC)…”
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Abstract 1319: Establishment and characterization of fresh primary human colorectal tumor implants by Miagkov, Alexei, Uzgare, Rajneesh, Zhong, Shaobin, Leary, Lisa, Ondrus, Janine, Hundley, Thomas, Sathyamoorthy, Malathi, Tiruchinapalli, Dhanrajan, Todaro, Nicole, Griffin, Christina, Mulpuri, Rao, Hostin, Damon, Otto, Jeffery, Chen, Hao

“…Abstract A personalized approach towards the therapy of colorectal carcinoma is critical for a successful outcome. In recent years, direct transfer xenograft…”
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